Endocrine-Related Cancer logo. OPEN FOR SUBMISSIONS 19th WorldMEN International Workshop Unmet Needs in Multiple Endocrine Neoplasia Syndromes Special Collection Collection Editors: Ana O. Hoff - Chief of Endocrine Oncology at Instituto do Cancer do Estado de São Paulo. Madson Q. Almeida - Associate Professor of Endocrinology and Metabolism, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo. Maria Luisa Brandi - Professor of Endocrinology, University of San Raffaele, Milan, Italy.

The WorldMEN 2025 Special Collection is inviting complementary papers from researchers who weren't able to attend the event but whose work meaningfully contributes to understanding the unmet needs in multiple endocrine neoplasia syndromes.

Learn more: erc.bioscientifica.com/page/WorldMEN-2025

Endocrine-Related Cancer logo. PRRT for well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs). By Virginia Corbett, Garima Gupta, and Aman Chauhan. Open Access logo. Figure 3. PRRT considerations. Endocrine-Related Cancer 33, 3; 10.1530/ERC-25-0495 Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

A new review by Virginia Corbett, Garima Gupta, and Aman Chauhan synthesises recent clinical trials, cohort studies, and expert consensus to clarify the role of peptide receptor radionuclide therapy in neuroendocrine tumours management.

Read the review #OpenAccess: doi.org/10.1530/ERC-...

Endocrine-Related Cancer logo. 80 Years 1946-2026 Society for Endocrinology logo. The Biology of Aging and Endocrine-Related Cancers: Shared Mechanisms and Interventions Special Collection. New Review. Ageing and pituitary neuroendocrine tumours (PitNETs): from bench to bedside. By Dario De Alcubierre et al. Graphical Abstract. doi.org/10.1530/ERC-25-0535.

Pituitary neuroendocrine tumours (PitNETs) in elderly people (≥65 years) is increasing as life expectancy rises.

A new review examines the biology & clinical features of PitNETs in elderly people to support further research in this patient population.

🔗 doi.org/10.1530/ERC-25-0535

Endocrine-Related Cancer logo. Establishment of patient-derived xenografts for neuroendocrine tumors in the avian embryo model. By Nilakshi Kulathunga et al. Figure 1. Establishment of human NET patient-derived xenografts (PDXs) within the avian embryo ex ovo model. (A) Flow chart of the PDX establishment procedure in the avian embryo ex ovo model. The numbers represent embryonic day of development. (B) Representative PDXs from PanNET and SI-NET primary tumors, lymph node, and liver metastasis. Top row: bright-field images. Bottom row: ultrasound B-mode images. Scale bar: 1,000 μm. (C) PDX tumor volume at the experimental endpoint, measured by ultrasound imaging. (D) Patient and NET characteristics from which tumor fragments were used to establish PDXs. PDXs were established from various tissue specimens from each patient, as indicated by the ‘tissue origin’. (E) PDX engraftment rate according to the patient’s sex, primary tumor location, grade, and tissue of origin. Endocrine-Related Cancer 33, 3; 10.1530/ERC-25-0377. Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

New research by Nilakshi Kulathunga et al. investigates whether the avian chorioallantoic membrane can support engraftment of tumour fragments from well‑differentiated NETs.

🔗Read the research #OpenAccess: doi.org/10.1530/ERC-25-0377

New Review. Giant cell tumor of the sphenoid bone: a systematic literature review with illustrative cases, By Tatiana Lecot-Connan et al. Dr Fanny Chasseloup AP-HP, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin Bicêtre, France Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Le Kremlin-Bicêtre, France Emerging Leaders 2025 Special Collection. Endocrine-Related Cancer logo. 80 Years 1946-2026 Society for Endocrinology logo.

Giant cell tumours rarely occur in the skull.

A new review summarises current understanding about these cases, reporting 79 sphenoid GCTs & adding 2 new cases.

This article forms part of our Emerging Leader Collection, featuring rising researcher Fanny Chasseloup 👏

🔗 doi.org/10.1530/ERC-24-0289

Special Collection. Advances and Innovations: The Next Chapter in Pheochromocytoma and Paraganglioma. New Research: Succinate dehydrogenase-deficient cancer cells have increased susceptibility to Ym155-induced DNA damage. Endocrine-Related Cancer logo. 80 Years 1946-2026 Society for Endocrinology logo.

A new study by Qianjin Guo et al. leveraged human SDHB-deficient UOK269 RCC cells (SDHB-KO) and isogenic SDHB-reconstituted control cells (SDHB-WT) to identify intrinsic susceptibilities of SDHB-deficient cancers that could be therapeutically leveraged.

Read the article: doi.org/10.1530/ERC-25-0397

Clinical and prognostic significance of parathyroid hormone-related protein in breast cancer: a systematic review and meta-analyses of observational studies in women. By Alisson Clemenceau et al. Endocrine-Related Cancer logo. Figure 1. PRISMA flow diagram. Adapted from Page et al. (51) (for more information, visit: https://www.prisma-statement.org/). Endocrine-Related Cancer 33, 3; 10.1530/ERC-25-0324. Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

Alisson Clemenceau et al. synthesises over 3 decades of human observational studies, using systematic review & meta‑analyses to examine how PTHrP relates to prognostic tumour characteristics & patient outcomes in women with breast cancer.

Read the full study #OpenAccess: doi.org/10.1530/ERC-25-0324

Endocrine-Related Cancer logo. New Guidelines. NANETS Guidelines for the diagnosis and management of stage I–III rectal neuroendocrine tumors. Endocrine-Related Cancer journal cover.

🆕 NANETS Guidelines for the diagnosis and management of stage I–III rectal neuroendocrine tumors

🔗 doi.org/10.1530/ERC-25-0303

Can GLP-1 receptor agonists, used to treat diabetes and obesity, play a role in #ProstateCancer?

A new study from University of Illinois Chicago researchers, published in @endocancer.bsky.social, explores the link.

Read more: https://bit.ly/4kRIonU

From Discovery Science to the Clinic - Heritable Endocrine Cancers and Related Disorder Special Collection. New Research. Comprehensive analysis of germline and somatic SDHA alterations reveals rare incidental germline variants and prognostic implications of somatic loss in breast cancer. By Henriett Butz et al. Endocrine-Related Cancer logo. 80 Years 1946-2026 Society for Endocrinology logo.

What is the clinical relevancy of germline & somatic SDHA pathogenic/likely pathogenic (P/LP) variants in cancer patients?

A recent comprehensive analysis by Henriett Butz et al. investigates prevalence & clinical relevance of germline & somatic SDHA P/LP variants.

doi.org/10.1530/ERC-25-0281

Endocrine-Related Cancer logo. New Research. Cabozantinib for advanced grade 3 neuroendocrine tumors: subgroup analysis of the phase 3 CABINET trial (Alliance A021602). By Jonathan R Strosberg et al. Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

Jonathan R Strosberg et al. publish a subgroup analysis of the phase 3 CABINET trial, evaluating outcomes in patients with well-differentiated grade 3 neuroendocrine tumours (G3 NETs; Ki-67 > 20%).

Read the article: doi.org/10.1530/ERC-25-0415

The Biology of Aging and Endocrine-Related Cancers: Shared Mechanisms and Interventions Special Collection. Endocrine-Related Cancer logo.

Call for Papers: The Biology of Aging and Endocrine‑Related Cancers

This collection aims to improve understanding of how aging biology influences endocrine‑related cancer risk, treatment responses, and patient outcomes.

For more info visit: erc.bioscientifica.com/page/Biology-of-Aging

Endocrine-Related Cancer logo. Biology of Aging and Endocrine-Related Cancers: Shared Mechanisms and Interventions Special Collection. Adrenal tumors in the elderly. By Abel Decmann et al. Graphical Abstract. Published by Bioscientifica. 80 Years SfE logo.

How does ageing shape adrenal tumours?

A new mini-review by Abel Decmann et al. summarises how age‑related changes in the adrenal cortex and medulla, from structural remodelling to shifts in immune & cellular balance, may influence tumorigenesis.

Read the article: doi.org/10.1530/ERC-25-0150

Endocrine-Related Cancer. RET@Thirty: Three Decades of Remarkable Progress. Special Collection.

Marking 30 years, the RET@Thirty Special Collection features an exclusive editorial with Professor Sir Bruce Ponder & brings together mini-reviews addressing the multifaceted aspects of RET & its impact on clinical practice.

Explore the collection: erc.bioscientifica.com/page/RET@Thirty

Endocrine-Related Cancer logo. Functional analysis of AIP variants in a cohort of neuroendocrine neoplasms. By Blanca R Carranza-Zavala et al. Figure 1. Initial assessment of AIP variants in the study cohort. (A) Coronal (left) and sagittal (right) representative gadolinium-enhanced T1-weighted preoperatory magnetic resonance images of Case 3, showing a pituitary macroadenoma. (B) Frequency of AIP variants within each clinical category included in the cohort of adult patients with NENs. (C) Schematic representation of AIP exons (top) and corresponding protein domains (bottom) displaying the VOI identified in this study. α-helix, carboxy-terminal alpha-helix; CS, Cushing’s syndrome; EO, early onset; GH, growth hormone; LB, likely benign; MEN, multiple endocrine neoplasia; MEN1, MEN type 1; MEN2A and MEN2B, MEN types 2A and 2B; MTC, medullary thyroid carcinoma; NENs, neuroendocrine neoplasms; NF1, neurofibromatosis type 1; P/LP, pathogenic and likely pathogenic; PanNEN, pancreatic neuroendocrine tumor; PHPT, primary hyperparathyroidism; PitNET, pituitary neuroendocrine tumor; PPGL, pheochromocytoma or paraganglioma; PPIase, peptidyl-prolyl cis–trans isomerase domain; TPR1, TPR2, and TPR3, tetratricopeptide repeats 1, 2, and 3; VHL, von Hippel–Lindau syndrome; VOI, variants of interest; VUS, variant of uncertain significance. Citation: Endocrine-Related Cancer 33, 1; 10.1530/ERC-25-0095. Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

Could AIP loss-of-function contribute to neuroendocrine neoplasms (NENs) beyond pituitary tumours?

Blanca R Carranza-Zavala et al. investigated the prevalence and in‑vitro effects of germline AIP variants in Mexican patients with NENs.

🔓 Full research #OpenAccess: doi.org/10.1530/ERC-25-0095

Endocrine-Related Cancer logo. Long-term calcitonin after thyroidectomy for medullary thyroid cancer in MEN2A. By Marijn L van den Berg et al. Figure 2. Postoperative calcitonin course during follow-up presented for each individual patient. Ctn, calcitonin; TTx, thyroidectomy; MTC, medullary thyroid cancer; ULN, upper limit of normal. Endocrine-Related Cancer 33, 1; 10.1530/ERC-25-0366. Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

A new study by Marijn L van den Berg et al. analyses long‑term calcitonin trends in 52 MEN2A patients after total thyroidectomy, revealing distinct postoperative patterns that could inform more personalised surveillance.

🔓 Read the full article: doi.org/10.1530/ERC-25-0366

Emerging Leaders 2025 Special Collection. Explore the 2025 Emerging Leaders Collection.

🌟 We take pride in our annual Emerging Leaders Special Collection, celebrating the knowledge & talent of exceptional early‑career scientists shaping the future of the field.

Explore the researchers and articles featured in our 2025 collection: erc.bioscientifica.com/page/emerging-leaders-2025

Endocrine-Related Cancer logo. 80 Years Society for Endocrinology logo. PDF screenshot of 'Expanding horizons in Endocrine-Related Cancer: innovation, imagination, and a shared global vision' (https://doi.org/10.1530/ERC-25-0497)

🚀 The new year marks an exciting transition for Endocrine-Related Cancer as Prof. Karel Pacak begins his term as Editor-in-Chief!

In a new editorial, Prof. Pacak outlines 5 principles that will guide the journal as a platform for collaboration, inspiration & progress: doi.org/10.1530/ERC-25-0497

Systems Biology Approaches in Hormone-Dependent Cancer Research. Themed Collection. Endocrine-Related Cancer logo. New Review: Hallmarks of disease: how tuned hierarchies of intelligent molecular neural networks (MNNs) may matter. By Hans V Westerhoff.

A new review by Hans V. Westerhoff explores how complexity, plasticity and circular causality make intracellular networks resemble trained neural networks. Comparing disease challenges with those in evolution or development may reveal 'learned' cellular responses.

🔗 doi.org/10.1530/ERC-25-0183

Endocrine-Related Cancer logo. New Associate Editor. Ilan Shimon, MD Head of the Endocrinology & Diabetes Institute at Rabin Medical Centre and Professor of Medicine at Tel Aviv University, Israel Society for Endocrinology logo.

We are delighted to welcome Professor Ilan Shimon, MD, as a new Associate Editor for Endocrine‑Related Cancer.

A leading clinical academic endocrinologist and former ENEA President, he brings extensive expertise in pituitary tumour research.

🔗 erc.bioscientifica.com

Endocrine-Related Cancer logo. New Research. Predictors of survival outcomes in patients with neuroendocrine neoplasms: a real-world retrospective study. By Marta Laganà et al. Published by Bioscientifica. Society for Endocrinology logo.

📊 Real-world survival outcomes in neuroendocrine neoplasms (NENs)

A retrospective study by Marta Laganà et al. analysed 239 patients with NENs (2010–2023), reporting overall survival (OS), progression-free survival (PFS), and key predictors.

Read the article: doi.org/10.1530/ERC-25-0243

Endocrine-Related Cancer logo. New Research: GLP1 receptor agonism alters growth and therapeutic response in prostate cancer. By Soumen Bera et al. Published by Bioscientifica logo. Society for Endocrinology logo.

New research by Soumen Bera et al. supports a model where GLP1R agonism blocks oncogenic pathways and growth of prostate cancer cells, pointing to potential therapeutic applications of semaglutide in advanced prostate cancer.

👉 Read the article: doi.org/10.1530/ERC-25-0185

Collection Curated by Prof. Karel Pacak. Incoming Editor-in-Chief of Endocrine-Related Cancer. Images of PDFs of a selection of the selected articles. Endocrine-Related Cancer logo.

⭐ Which articles are shaping the conversation in endocrine oncology?

Our incoming Editor‑in‑Chief, Professor Karel Pacak, has curated his first Editors’ Choice Collection.

📚 Explore the collection: erc.bioscientifica.com/page/edchoice/editors-choice

Endocrine-Related Cancer logo. New Review: Towards harmonised paediatric thyroid cancer care: adult comparisons and gaps. By Michaela Kuhlen, Marina Kunstreich, and Antje Redlich. Published by bioscientifica logo. Society for Endocrinology logo.

A new narrative review by Michaela Kuhlen, Marina Kunstreich and Antje Redlich explores how paediatric and adult DTC differ across biology, presentation, treatment strategies and guidelines, highlighting the need for harmonised, age‑specific approaches.

doi.org/10.1530/ERC-25-0191

Top left: Endocrine-Related Cancer logo. Text: Explore and contribute to expert-curated research on hormone-related cancers. Bottom right: Society for Endocrinology logo.

Spotlighting our latest completed collections & our open collections for submissions.

✅ 𝗖𝗼𝗺𝗽𝗹𝗲𝘁𝗲𝗱 𝗖𝗼𝗹𝗹𝗲𝗰𝘁𝗶𝗼𝗻𝘀:
🔎 𝙍𝙀𝙏@𝙏𝙝𝙞𝙧𝙩𝙮 - bit.ly/4p9qspY
🔬 𝙏𝙝𝙚 𝙒𝙖𝙧𝙗𝙪𝙧𝙜 𝙀𝙛𝙛𝙚𝙘𝙩 - bit.ly/4rb6eOs

💡 𝗢𝗽𝗲𝗻 𝗳𝗼𝗿 𝗦𝘂𝗯𝗺𝗶𝘀𝘀𝗶𝗼𝗻𝘀:
🌱 𝙃𝙚𝙧𝙞𝙩𝙖𝙗𝙡𝙚 𝙀𝙣𝙙𝙤𝙘𝙧𝙞𝙣𝙚 𝘾𝙖𝙣𝙘𝙚𝙧𝙨 - bit.ly/43A22O7
🧠 𝙋𝙞𝙩𝙪𝙞𝙩𝙖𝙧𝙮 𝙏𝙪𝙢𝙤𝙪𝙧𝙨 - bit.ly/4p9qTk6

Headline text: Welcome our new Associate Editor... Headshot of Joakim Crona, MD, PhD Text reads: Joakim Crona, MD, PhD, Associate Professor, Uppsala University, Sweden Bottom left: Endocrine-Related Cancer logo. Bottom right: Society for Endocrinology logo.

Please join us in welcoming Dr. Crona to the Endocrine-Related Cancer community.

Dr. Crona is Associate Professor at Uppsala University, Sweden, and a clinical oncologist with a special interest in endocrine neoplasia.🚀

Endocrine-Related Cancer. 2025 Best Paper Award. Bioscientifica. Society for Endocrinology.

🏆 As we approach the end of 2025, we’re launching the Endocrine-Related Cancer Best Paper Award - celebrating the most outstanding articles published in 2025.

Papers will be selected by our editorial leadership, with 1st place awarded £1000 💜 Stay tuned, selection will take place in 2026!

Today, we stand with the global community in recognising everyone affected by neuroendocrine cancer.

At Endocrine-Related Cancer, we remain committed to publishing high-quality research that advances understanding of NETs to optimise patient care.

🔗 lnkd.in/eBY6uA_r

#WorldNeuroendocrineCancerDay

Special Collection. Advances and Innovation: The Next Chapter in Pheochromocytoma and Paraganglioma. Endocrine-Related Cancer.

We’re excited to announce a new Special Collection featuring the most significant clinical & scientific presentations from the 7th International Symposium on Pheochromocytoma.

🔗 For more info: lnkd.in/d3gyVVbg

Collection Editors: Prof. Isabelle Bourdeau, Prof. Karel Pacak
& Prof. André Lacroix

🎉 Excited to share our new publication!

Targeted inhibition of netrin–DCC axis with NP137 reverses netrin-driven survival in vitro & reduces high-grade pancreatic NEN progression in vivo.

Potential therapeutic strategy for aggressive PNENs?

bit.ly/435pKBx

@endocancer.bsky.social