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Posts by Julien Ochala

Our new project unveiling an integrative single-fiber framework that connect multi-omic cellular heterogeneity to molecular function in ICU-related muscle wasting! Congratulations to all authors especially Alexandra who led the whole project! Thank you to @lundbeckfonden.bsky.social for the support

2 months ago 4 2 0 0

Very interesting study unravelling cardiac myofibrillar plasticity in the animal kingdom! Huge effort from colleagues at CU Boulder (with very humble contribution from our lab)

2 months ago 2 0 0 0
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Postdoc in cardiac sarcomere biology at Department of Biomedical Sciences Postdoc in cardiac sarcomere biology at Department of Biomedical Sciences  Faculty of Health and Medical Sciences University of Copenhagen We are looking f

Postdoc opportunity in our group in sunny Copenhagen ☀️ candidate.hr-manager.net/ApplicationI...

2 months ago 1 0 0 0
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Destabilization of cardiac myosin acetylation and sequestration with type 2 diabetes mellitus - Cardiovascular Diabetology Background Type 2 diabetes mellitus (T2DM) predisposes patients to adverse cardiac remodeling even before the development of cardiomyopathic symptoms. The mechanisms for such early perturbations remai...

Our latest collaborative work highlighting an early cardiac myosin dysfunction in diabetic patients (even without any cardiomyopathy)! @ucph.bsky.social funded by @novo-nordisk.bsky.social

3 months ago 2 0 0 0
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Multi-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer - Nature Metabolism Multi-omics profiling of diverse cancer cachexia models uncovers a multi-tissue metabolite-coordinated response associated with disease progression and links multi-tissue one-carbon metabolism to wast...

Impressive study!

3 months ago 1 1 0 0
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When to target the most abundant protein in the heart?

@droch.bsky.social & team show myosin becomes maladaptive in X-linked myotubular myopathy, consuming excessive energy, and inhibiting its ATPase activity in mice partly rescues the molecular defects: doi.org/10.1172/jci....

3 months ago 2 1 0 0
Ochala Group – University of Copenhagen

Our team at Københavns Universitet - University of Copenhagen will soon be looking for a postdoc with experience in AI-driven vHTS and cardiac sarcomere modeling. If interested please send me an email. Spread the word :-)

4 months ago 4 3 0 0
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Assaying the myosin super-relaxed state across muscle types, cells and proteins for understanding muscle biology and use in drug discovery - Nature Protocols The Mant-ATP assay is a simple and accessible means for rapid quantitative assessment of the ratio of super-relaxed myosin to disordered relaxed myosin. This protocol provides a standardized methodolo...

Great collaborative work led by Christopher Toepfer and his team at the University of Oxford

4 months ago 10 4 1 0
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Reader in/Professor of Immunobiology | King's College London

We are recruiting a Reader/Professor of Immunobiology at @kingslsm.bsky.social . This is a unique opportunity to shape basic immunology at @kingscollegelondon.bsky.social . Please RP.
www.kcl.ac.uk/jobs/131447-...

4 months ago 5 5 0 0
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Top selling from pharma companies

4 months ago 0 0 0 0
Cardiac Chamber‐Specific Regulation of Myosin Biochemical Super‐Relaxation and Auto‐Inhibition The combination of Mant-ATP (2′-(or-3′)-O-(N-Methylanthraniloyl) Adenosine 5′-Triphosphate) chase experiments and all-atomistic molecular dynamics simulations, revealed that myosin auto-inhibition an...

Our collaborative effort unravelled puzzling results warranted more research on the topic of myosin and cardiac chamber specificities @ucph.bsky.social

4 months ago 0 1 0 0
JCI Insight - Myosin inhibition partially rescues the myofibre proteome in X-linked myotubular myopathy

Excited to present our recent work on myosin as a molecular target for genetic muscle diseases! Kudos to all authors, especially Elise, Fanny and @myofinlab.bsky.social @ucph.bsky.social

5 months ago 6 2 0 0
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Asterix and/et Ozempix

5 months ago 5 0 0 0

Recruiting a comp PDRA for the lab 🚨

Working on multiple projects using integrated multi omics in bulk & single cell level

Passion for data, coding, bioinformatics & keen to lead our labs comp workflow

12 months in first instance but extendable for further 19 months

my.corehr.com/pls/coreport...

5 months ago 4 4 0 0

Multilingualism protects against accelerated aging www.nature.com/articles/s43...

5 months ago 2 0 1 0

We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle

Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!

5 months ago 6 5 0 0

We are grateful to Independent Research Fund Denmark for funding our new project aiming to understand and treat heart failure! The project will take place at @ucph.bsky.social

5 months ago 6 1 1 0
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Congratulations Glenn and team 👏

6 months ago 2 0 0 0

Congratulations! Impressive work!

6 months ago 1 0 0 0

Very nice 👍👏

6 months ago 0 0 0 0

👏 very important paper

6 months ago 0 0 0 0
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Ensure #ISHLT2026 will be next level. ▶️ Submit your science in the treatment of advanced #heart and #lung disease, #transplantation, #MCS, and #PVD by 📆 14 October: 🔗 https://bit.ly/4dLYGdn

6 months ago 1 1 0 0
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14 postdoctoral fellowships to the BRIDGE – Translational Excellence Programme

We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere

6 months ago 4 4 0 1

The Danish system NEM ID is actually working and very efficient! However DK is far smaller than UK…

6 months ago 1 0 0 0
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Fully agreed- diversity is key

6 months ago 1 0 0 0
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Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London

🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important

Good collab with @droch.bsky.social so travel to CPH involved as well

www.kcl.ac.uk/jobs/126245-...

6 months ago 6 8 0 1

Drugs targeting muscle mass seem to be trendy at the minute (but a lot of them are unfortunately left along the way)

6 months ago 1 0 0 0
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Eli Lilly halts trial testing experimental muscle-preserving drug with Zepbound Eli Lilly has halted a study of an experimental drug, designed to prevent obesity patients from losing too much muscle, due to strategic business reasons, according to a U.S. registry of clinical trials.

This trial has been stopped for strategic business reasons

6 months ago 3 0 1 0
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Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London

Postdoc opportunity in muscle cell biology! You would not only be involved in an ambitious project but would also help develop cutting edge methods! Highly recommended! @robertseaborne.bsky.social

6 months ago 6 6 0 0
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UAB and Children's of AL is looking for a new Division Director of Pediatric Neurology (come be one of my bosses!). We are consistently in the top 30 nationwide in Pediatric Neurology and have excellent subspecialties in: Epilepsy, Autism, and NMDs. Apply: tinyurl.com/y8d8duve

7 months ago 2 3 0 0