#CNRSLeJournal 📜 | Sébastien Bontemps-Gallo, bactériologiste au @ciilofficiel.bsky.social, étudie des tiques de l’espèce "Ixodes ricinus", celle qui nous pique le plus, pour aider au diagnostic de la maladie de Lyme 🪲

➡️ lejournal.cnrs.fr/articles/tiq...

When Yersinia pestis, plague bacillus, enters the flea gut during a blood meal, it encounters a highly oxidative environment. This work shows that host plasma proteins - particularly albumin - act as transient allies, helping the bacterium withstand early oxidative stress and initiate colonization.

Plasma albumin contributes to early Yersinia pestis survival at the onset of flea infection Author summary Plague is caused by the bacterium Yersinia pestis and transmitted between mammals by fleas. To spread, the bacteria must survive in the flea gut after a blood meal. This environment is ...

📢 A new pub in @plos.org Pathogens by A. Dewitte, F. Sebbane and S. Bontemps-Gallo

“Plasma albumin contributes to early Y. pestis survival at the onset of flea infection"

@cnrs-hautsdefrance.bsky.social @cnrsbiologie.bsky.social @inserm.fr @pasteurlille.bsky.social @rechercheulille.bsky.social

Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis - The EMBO Journal Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a prev...

🎉 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐧𝐞𝐰 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐓𝐡𝐞 𝐄𝐌𝐁𝐎 𝐉𝐨𝐮𝐫𝐧𝐚𝐥!

After 8 months of revision, our work is now online: shorturl.at/WHmFq

We uncover a previously unrecognized way that 𝑀𝑦𝑐𝑜𝑏𝑎𝑐𝑡𝑒𝑟𝑖𝑢𝑚 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠 survives toxic metal stress during infection.
...

Notre identité, notre héritage, notre avenir ! YouTube video by Pasteur Lille

Né il y a plus de 130 ans, l’Institut Pasteur de Lille met la science au service de la santé.

Aujourd’hui, nous faisons évoluer notre identité pour mieux refléter notre engagement collectif.

🎬 Découvrez notre nouveau film qui raconte qui nous sommes et où nous allons.

youtu.be/UyxvGUHWWtk?...

Multiple protein structure alignment at scale with FoldMason Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social.
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...

Our new website is now live!

A redesigned interface to better showcase our research, teams, and latest news.

➡️ www.ciil.fr

@cnrs-hautsdefrance.bsky.social @inserm.fr @cnrs.fr @pasteurlille.bsky.social @rechercheulille.bsky.social

#BonneAnnée 🌟 Le #CNRS vous présente ses meilleurs vœux pour l'année 2026 !

#HappyNewYear 🌟 The French National Centre for Scientific Research (CNRS) wishes you the very best for 2026!

Insights into infectious diseases through ancient pathogen genomics - Nature Reviews Microbiology In this Review, Kocher, Krause and Spyrou explore how ancient pathogen genomics is providing new perspectives on the history and evolution of infectious agents. They show how ancient DNA has revealed ...

A fascinating Review in Nature Reviews Microbiology shows how ancient pathogen genomics reshapes our understanding of infectious diseases. For Yersinia pestis, it synthesizes decades of work on plague evolution, while highlighting key open questions ahead.

#microsky

Brève de science : pourquoi certaines bactéries résistent-elles aux antibiotiques ?

Pourquoi certaines bactéries résistent-elles aux antibiotiques ? 🦠💊 Sébastien Bontemps-Gallo, bactériologiste au CNRS, tente d'y répondre.

Maladie de Lyme : comment la bactérie Borrelia burgdorferi nous infecte Transmise par les tiques, la maladie de Lyme est causée par des bactéries capables de se camoufler, de s’adapter et de résister à nos défenses immunitaires grâce à d’ingénieux stratagèmes.

🦠 "Maladie de Lyme : comment la bactérie Borrelia burgdorferi nous infecte", un article de @sebbontempsgallo.bsky.social (@cnrs-hautsdefrance.bsky.social / @univlille.bsky.social) pour @france.theconversation.com 👇
theconversation.com/maladie-de-l...

Selective accumulation of nanoparticles in infected cells for targeted drug delivery In response to the escalating threat of infectious diseases and antimicrobial resistance, novel therapeutic strategies are under active development. A…

📢 A new pub in Journal of Controlled Release by Dr @arnaudmachelart.bsky.social group and Dr Ruxandra Gref team

“Selective accumulation of nanoparticles in infected cells for targeted drug delivery”

@inserm.fr @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social @pasteurlille.bsky.social

Maladie de Lyme : comment la bactérie « Borrelia burgdorferi » nous infecte Transmise par les tiques, la maladie de Lyme est causée par des bactéries capables de se camoufler, de s’adapter et de résister à nos défenses immunitaires grâce à d’ingénieux stratagèmes.

#Recherche
Issus du décryptage de la méthode de camouflage très efficace de la bactérie responsable de la maladie de #Lyme, 2 projets de #vaccins permettent de l’attaquer avant qu’elle ne puisse recourir à ce stratagème.
Par @sebbontempsgallo.bsky.social de @cnrs.fr

Félicitations pour cette nouvelle étape et bonne continuation à Bordeaux !

@pasteurlille.bsky.social @rechercheulille.bsky.social @cnrs.fr @cnrsbiologie.bsky.social @inserm.fr @chulille.bsky.social

Maladie de Lyme : comment la bactérie « Borrelia burgdorferi » nous infecte Transmise par les tiques, la maladie de Lyme est causée par des bactéries capables de se camoufler, de s’adapter et de résister à nos défenses immunitaires grâce à d’ingénieux stratagèmes.

Nouvel article dans @theconversation.com FR : Maladie de Lyme : comment la bactérie Borrelia burgdorferi nous infecte
Comment cette bactérie déjoue notre système immunitaire et inspire de nouvelles pistes vaccinales

@cnrs-hautsdefrance.bsky.social @univlille.bsky.social

🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨 (2.5y)

🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a @anrs-mie.bsky.social PEPR-funded project!

🔬 Profile: PhD in microbiology

#Postdoc #Microbiology #YersiniaPestis #ResearchJobs

🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨

🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a PEPR-funded project! (2.5y)

🔬 Profile: PhD in microbiology

#Postdoc #Microbiology #YersiniaPestis #ResearchJobs

@cnrs-hautsdefrance.bsky.social @univlille.bsky.social @rechercheulille.bsky.social @inserm.fr

The Plague & Yersinia pestis team @pasteurlille.bsky.social , led by F Sebbane, shared their latest research at the Yersinia 15th Symposium in Ulaanbaatar! A Baillez presented his thesis work, A Dewitte and @sebbontempsgallo.bsky.social showcased their recent findings.
@rolandelliagus.bsky.social

First day of the 15th International #Yersinia symposium in Ulaanbaatar, Mongolia

🎓 Funded PhD position available in the team of M. Pichavant & P. Gosset! Send your CV and a brief note on why you’re excited about this opportunity.

@cnrs-hautsdefrance.bsky.social @pasteurlille.bsky.social @univlille.bsky.social @inserm.fr @chulille.bsky.social

Cas de peste détecté aux États-Unis : peut-on encore mourir de cette maladie ? | Ouest-France [Ouest-France] Un cas de peste a été détecté en Californie, aux États-Unis, mardi 19 août. Pourrait-on voir réapparaître la bactérie responsable de la maladie en France, où la dernière infection connu...

⚠️ Cas de peste détecté aux USA : peut-on encore mourir de cette maladie ? Le 19 août 2025 un cas a été confirmé en Californie

Dans un article @ouest-france.fr Dr Sebbane, Chef d'équipe @inserm.fr fait le point.

@pasteurlille.bsky.social @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social

Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel Quantifying the phosphorylation levels of proteins involved in bacterial signaling pathways is essential for understanding their role in stress adaptation and infection processes. Here, we present a protocol for the semi-quantitative assessment of the phosphorylation level of the transcriptional regulator CpxR during the infection process using Phos-tag gel. We describe steps for Dickeya dadantii infection of chicory leaves, followed by bacterial extraction, rapid acidic cell lysis, and subseque...

Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel #protocol #starprotocols #cellpress

Insights into Yersinia pestis evolution through rearrangement analysis of 242 complete genomes - Nature Genetics Analysis of synteny blocks and genomic rearrangement patterns of 178 newly sequenced and 64 publicly available complete genomes of Yersinia pestis highlights the impact of key variations on genes invo...

Just out in Nature Genetics @natureportfolio.nature.com !

Wu et al. analyzed 242 Yersinia pestis genomes, uncovering IS-driven rearrangements, which enhanced #phylogenetic resolution and resolved the third #pandemic’s polytomy, revealing adaptive changes in #virulence and #stress response.

This work was funded by the @cnrs.fr through MITI and the @agencerecherche.bsky.social

@pasteurlille.bsky.social @univlille.bsky.social @fst-ulille.bsky.social @inserm.fr @chulille.bsky.social

Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel Quantifying the phosphorylation levels of proteins involved in bacterial signaling pathways is essential for understanding their role in stress adapta…

New pub in STAR Protocols @cp-starprotocols.bsky.social to detect the phosphorylation level of response regulators of two-component systems during host infection using a Phos-tag approach.

By @ugsf-lille.bsky.social @ciilofficiel.bsky.social
@univlille.bsky.social @cnrs-hautsdefrance.bsky.social

[Resources]

#AlphaFold protein and PPI prediction databases

1️⃣ Predictomes (genome maintenance & H2A/H2b) predictomes.org

2️⃣ Flypredictome www.flyrnai.org/tools/fly_pr...

3️⃣ Human interactome prodata.swmed.edu/humanPPI

4️⃣ BFVD (viral proteins) bfvd.steineggerlab.workers.dev

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Bacterial cell wall & periplasm paradigm shift - important read #MicroSky

www.nature.com/articles/s41...

Climate differentially impacts ticks infected and uninfected with Borrelia burgdorferi Climate parameters show negative correlations with B. burgdorferi infection prevalence but low impact on uninfected tick density.

#Climate extremes may reduce #Lymedisease risk?

Broughton et al. show Borrelia burgdorferi prevalence in Ixodes pacificus ticks declines under climate stress—challenging long-held assumptions about vector-borne disease and global warming.

#VectorBiology