Timing of cow’s milk oral immunotherapy and adverse reactions in children: A 15-year experience Cow’s milk allergy (CMA) is one of the most common food allergies in children and may persist into later childhood. Oral immunotherapy (OIT) is an effective treatment option; however, the optimal timi...

This study evaluated the clinical efficacy and safety of patients in different age groups who were started on Cow's Milk oral immunotherapy based on real-life data on reaction profiles and treatment processes. See what they learned: www.annallergy.org/article/S108...

2025 Inborn errors of immunity practice parameter The Joint Task Force on Practice Parameters (JTFPP) was commissioned by the American Academy of Allergy, Asthma & Immunology (AAAAI) and the American College of Allergy, Asthma and Immunology (ACAAI) ...

Since the last practice parameter for inborn errors of immunity (IEI) in 2015, there have been significant advances in genetic testing and identification of novel pathogenic gene variants causing IEI. See the latest practice parameter here: www.annallergy.org/article/S108...

Racial differences in penicillin allergy delabeling in a multicenter US primary care cohort Penicillin allergy labels affect 1 in 10 people but are uncommonly reflective of a true, IgE–mediated allergy. Penicillin allergy–labeled patients have increased exposure to broad-spectrum antibiotics...

Although 1 in 10 people have a penicillin allergy label on their electronic health record, more than 90% do not truly have penicillin allergy. This study looks at racial differences in penicillin allergy mislabels, a process termed “delabeling.” www.annallergy.org/article/S108...

This study demonstrates differences in self-reported food allergens by race/ethnicity and anaphylaxis symptom recognition, epinephrine access, and food allergy-related health care utilization by race/ethnicity and insurance status. Find out what they learned: www.annallergy.org/article/S108...

Who actually has asthma? Researchers explored incorporating spirometry with bronchodilator response to determine asthma incidence, severity, control, and diagnostic performance across 4 definitions in patients hospitalized for bronchiolitis in the 1st year of life. www.annallergy.org/article/S108...

The March issue of Annals of #Allergy, #Asthma & #Immunology is everything #Immunodeficiency. A new #PracticeParameter to an outstanding review of #CVID - this issue is packed with info so you can provide up-to-date care for your patients! @annalsacaai.bsky.social #MedSky
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The shared decision-making process may have an important function for providers: helping to assess whether a family's anxiety level and investment in the process makes their child a good fit for oral immunotherapy treatment for food allergies. www.annallergy.org/article/S108...

Among children with food allergies (FA), 77% report a history of atopic dermatitis (AD), with more than 80% of children with FA developing AD within the first year of life. So which factors are involved with early onset or late onset AD? Find out: www.annallergy.org/article/S108...

Simple request for #NoKings day!!

Lessons from the American College of Allergy, Asthma and Immunology inborn errors of immunity survey Inborn errors of immunity (IEIs) have been increasingly well characterized on the molecular and genetic levels. Their clinical recognition and management among practicing allergist-immunologists remai...

A study of consultative practices, management of allergist-immunologists engaging in inborn errors of immunity care demonstrates a critical need for enhanced training, access to multidisciplinary support, and targeted CE to optimize care for patients. www.annallergy.org/article/S108...

Long-term prophylactic treatment preferences and willingness to switch therapy in individuals with hereditary angioedema Long-term prophylaxis (LTP) can help manage hereditary angioedema (HAE). With increasing LTP treatment options, understanding patients’ preferences is important for shared decision-making.

When effectiveness is equal, some hereditary angioedema patients prefer injectable medication, others an oral administration for long term prophylactic (LTP) treatment. By better understanding patients’ preferences, LTP recommendations can be individualized. www.annallergy.org/article/S108...

Sex-based differences in perioperative hypersensitivity Perioperative hypersensitivity (POH) is a rare, immediate hypersensitivity reaction. Its more severe form, perioperative anaphylaxis, has a 2% mortality rate. Sex is a biological variable that can aff...

This study aims to assess sex-based differences in perioperative hypersensitivity and explore potential differences by age, culprit drugs and reaction severity. www.annallergy.org/article/S108...

Characterization of food protein-induced enterocolitis syndrome among Asian American children Limited data currently exist regarding the clinical characteristics of food protein-induced enterocolitis syndrome (FPIES) among Asian American (AsA) children.

A large pediatric Asian American FPIES cohort demonstrates distinguishing features, including a high proportion of egg FPIES and lack of common food co-associations. Understanding these differences may enhance clinicians’ ability to diagnose, manage FPIES. www.annallergy.org/article/S108...

Biphasic, refractory, and life-threatening anaphylactic reactions to iodinated contrast media Iodinated contrast media (ICM) is widely used in computed tomography (CT) imaging, with approximately 120 million doses administered globally annually. Although generally safe, ICM-induced anaphylacti...

Iodinated contrast media is used in radiology to enhance visibility of organs and blood vessels for patients undergoing CT imaging. A study evaluates the frequency of anaphylactic reactions to ICM during contrast-enhanced CT imaging. Learn more. www.annallergy.org/article/S108...

Hyperglycemia, receptor for advanced glycation end products, and small airways dysfunction in asthma Diabetes and insulin resistance are associated with higher risk of asthma exacerbation and preserved ratio impaired spirometry (PRISm), but the pathophysiology is unclear. These conditions may cause s...

This study reveals that hyperglycemia was associated with small airway dysfunction and preserved ratio impaired spirometry in asthma. Soluble receptor for advanced glycation end products may be a biomarker of hyperglycemia-associated lung dysfunction. www.annallergy.org/article/S108...

Basophils in atopic dermatitis Atopic dermatitis (AD) or eczema is a chronic inflammatory skin disease, characterized by dysfunction of the epidermal skin barrier causing increased sensitization to environmental allergens. The resu...

Basophils are gaining recognition as clinically actionable contributors to atopic dermatitis. The basophil activation test offers promise for assessing AD pathogenesis and response to treatment. www.annallergy.org/article/S108...

Modelling lung function trajectories through life course Lung function development reflects a complex interplay of biological, environmental, and social factors, with early-life disruptions linked to long-term respiratory and systemic outcomes. In this revi...

A study assesses how lung function trajectories have been modelled across the literature, combining systematic search with bibliometric analysis of 1919 longitudinal studies. To advance lung function research, a more comprehensive approach is required. www.annallergy.org/article/S108...

Interleukin-31 targeting and other novel drugs in itch Chronic pruritus is a debilitating symptom of several inflammatory skin conditions, presenting severe quality-of-life decreasing effects and major clinical challenges in terms of disease management. I...

Read a focused overview of inflammatory conditions in which pruritus is the major burden, learn about fundamental immune pathways, and sensory circuits involved, as well as efficacies and safety profiles of novel therapies addressing chronic pruritus. www.annallergy.org/article/S108...

The American College of Allergy, Asthma & Immunology (ACAAI) is supporting a new trial initiative by Annals of Allergy, Asthma & Immunology to support Open Access of NIH-funded research. Learn more. www.annallergy.org/article/S108...

The March issue of Annals of #Allergy, #Asthma & #Immunology is now available. Learn about current and future treatments for #urticaria. As always the most up-to-date information allows you to take best care of your patients.
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Learn what the most cited articles from Annals are! Access them in the Most Cited area about halfway down the Annals homepage: www.annallergy.org

Discovery is happening now in Philadelphia! This stand-alone event focuses on New Mechanisms of Type 2 Immunity with sessions designed to accelerate translational research. #AAAAI26

Predictive value of eosinophil-to-lymphocyte ratio combined with computed tomography scores for olfactory recovery in chronic rhinosinusitis with nasal polyps Chronic rhinosinusitis with nasal polyps (CRSwNP) is a debilitating inflammatory disease often complicated by olfactory dysfunction. Despite surgery being a primary treatment, predicting postoperative...

This article investigates the predictive effect of eosinophil-to-lymphocyte ratio from peripheral blood tests, combined with ethmoid sinus-to-maxillary sinus ratio, and ethmoid sinus score minus maxillary sinus score on olfactory recovery in patients with CRSwNP. www.annallergy.org/article/S108...

Do you want to write an article for Annals? Here are our guidelines: www.annallergy.org/content/auth...

Effect of tezepelumab on asthma exacerbations co-occurring with infection-attributed acute respiratory illnesses Tezepelumab, a human monoclonal antibody, blocks the activity of thymic stromal lymphopoietin. In the phase 2b PATHWAY (NCT02054130) and phase 3 NAVIGATOR (NCT03347279) studies, tezepelumab reduced ex...

Does tezepelumab reduce asthma exacerbations attributed to respiratory infections in patients with severe, uncontrolled asthma compared with placebo? Irrespective of perennial allergy status? Find out: www.annallergy.org/article/S108...

Wonder what your colleagues are reading in Annals? Take a look at the Most Read (Last 30 Days) section of the Annals homepage and find out! www.annallergy.org

Did you read the article we posted on Tuesday? Have thoughts to share? We welcome correspondence. Share yours here: annals@acaai.org

Airway overlap syndromes with asthma The airways, defined as the segment of the respiratory system extending from the pharynx to the alveoli, represent a crucial site for various inflammatory airway diseases. Among the most common are as...

The most common inflammatory airway diseases are asthma, chronic obstructive pulmonary disease, bronchiectasis, and obstructive sleep apnea. Overlap syndromes involving asthma are especially frequent and often exhibit bidirectional relationships. Learn more. www.annallergy.org/article/S108...

With at least 14 states restricting cell phone use in schools, allergist-immunologists may increasingly be asked to write letters of medical necessity for a child to carry a cell phone at school. https://loom.ly/IDMPGaI

It is here - the February issue of Annals of Allergy, Asthma & Immunology! This month we focus on #atopic #dermatitis. Find the information needed to provide the best care to your #allergy patients. #MedSky #Immunology @annalsacaai.bsky.social

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