Oh my god, this is my job!!! I can finally add something back to all the people who’ve given me knowledge

Left-YIMBYism, like Mamdani's, is going to win.

Chromosomes stuck behind the spindle are ticking time bombs for aneuploidy. We uncovered a mechanical rescue mechanism where microtubule pivoting repositions these high-risk chromosomes! Out last week in @natcomms.nature.com, here's a thread 🧵
shorturl.at/OD89x

Angine de Poitrine - Full Performance (Live on KEXP) YouTube video by KEXP

This coastal Californian visited Montreal in the dead of winter and loved it, I could totally see moving there and learning French. Amazing food. And the music... youtu.be/0Ssi-9wS1so?...

I'm Josh Hawn, and I support this message.

Everyone I know with practically any knowledge of global supply chains be like:

It's still decommodificstion when housing can only be acquired through inheritance, right?

The funny thing about these politics is that they say "there's no solution to housing problems, vote for me!"

Molotch: “A wonderful contribution to urban political theory as well as a concrete guide for how to exploit new opportunities for moving urban America forward. . . . Santa Cruz becomes a laboratory for understanding how to take and hold power, and for seeing what local power can and cannot do.”

This seems far descriptive of reality than the "growth coalition" theory that I first encountered in a local history, The Leftmost City. It also aligns well with Adkins' et al The Asset Economy. Rentierism is by far the dominant force in my city. whorulesamerica.ucsc.edu/santacruz/Th...

“No for-profit company could possibly withstand all the false leads required by that process,” he recalled telling them, “all the weird, random science that never panned out.”

Super grateful for this piece highlighting the threats to this country’s biomedical research infrastructure

Join the movement at @calelectricrail.org !

Most cloud infrastructure engineering amounts to this, but is a bit less fun

Zone 2 cardio. Mobility maxxing. There will be no further discussion.

We are not ready for Claudewitz

I'm open to Yee when the pool is so uninspiring, but Yee's stance on weak housing stances are untenable. California is pricing out so many people with lower incomes, and that's the core financial flaw of the state. If she could adopt Mamdani's policies I'd be a lot happier.

Epistasis and co-adaptation in bacterial genome evolution - Nature Reviews Genetics Bacterial genome evolution is shaped by epistasis, which can constrain or promote specific evolutionary paths. The authors review how integrating the effects of epistatic interactions into population-...

Epistasis and co-adaptation in bacterial genome evolution www.nature.com/articles/s41... #epistasis #microbiology #evolution #genomics

You can always tell when Russia is scared about the status of their genocidal invasion, because they activate ludicrously false propaganda pushes in US media.

Russian lines are breaking for the first time in a long while, so Foreign Affairs is publishing Michael Desch carrying water for Putin.

Realised I can display live posts on the map
bluesky-map.theo.io?live=1

(there's also an option under the settings cog to display post text, in case you really want to be overstimulated)

Alfred, Igor, and Mark on a stage at a rally for Ukraine in San Francisco. Igor is at the mic. There are US and Ukrainian flags in the background

A large crowd marches down a wide sidewalk in San Francisco, holding Ukrainian flags and signs

Several hundred turned out for today's Bay Area rally for continued support of Ukraine's fight for freedom and survival!

Berkeley councilmember @igortregub.bsky.social led the march, councilmember @markhumbert.bsky.social was also at the rally. ✊💙💛🇺🇦

Thanks so much for showing up, Alfred! So many that wanted to be there are unable to show up in an age when refugees with proper legal status are still being detained and deported.

Things are changing fast, turns out that the conservatives think the Chamber is now a "left-wing, open borders supporting activist group" bsky.app/profile/jose...

“Asked how the cuts have affected science, one [researcher] said, ‘This is like asking, how do you think dropping an atomic bomb on New York City will affect the future of Broadway musicals? This is a generational loss of innovation, technology, and economic power.’” 🔗 archive.ph/2026.02.12-1...

‘My duty is to call it out’: Judge accuses Trump administration of discrimination against minorities The Reagan-appointed judge ordered the NIH to restore funds for research related to racial minorities and LGBTQ+ people.

They give away the game when they make up a straw man of people thinking "it's a sin to be white" because when they get power their intention is to make it a sin to *not* be white, or Christian, or whatever.

Even Reagan judges call it out: www.politico.com/news/2025/06...

Person A: It's unfair that you are paying far less in taxes than me for an identical home.

Person B: But have you considered that I hadn't been underpaying for just one year, but many years?

Science takes a village. Thanks to everyone who has mentored a scientist, and all those awesome mentees.

Indeed, my only surprise is that in silico tools would drive the drug program. I've always seen new structure data be combined with these tools.

Really? That's great to hear. Do you mean the protein structure alone, or pose estimates? Though I've seen pose estimation and binding affinity prediction (Boltz) used for guiding screens, I hadn't heard of individual predictions being strong enough.

I see a lot more crystal structures and cryoEM experiments to validate the shaky hypotheses that AlphaFold-alikes generate. Nobody is launching a new small molecule drug program on the basis of AlphaFold results, but they may do a ton of physical experiments because of them.

Almost no one does, which is why we are in this mess. The documentation in the Epstein emails is a good chance for us figuring out why Ukraine needs to win, but every day here is filled with so much corruption and tyranny that it's hard for the story to break through.