Thanks to the US FDA Division of Bacterial, Parasitic, and Allergenic Products for the invitation to speak and thanks to
to the National Health and Medical Research Council, Women's & Children's Hospital Foundation and Flinders Foundation for ongoing support for our work in this area.

I'm looking forward to presenting tonight to colleages in the U.S. Food and Drug Administration Office of Vaccines Review and Research on our ongoing work to understand how disruption of the microbiota in early life leads to impaired vaccine immunogenicity.

Gut bacteria may explain why antibiotics make vaccines less effective It has long been a mystery why antibiotics reduces the effectiveness of some vaccines, but researchers believe bacteria in the gut may play a pivotal role.

Thanks to ABC news for featuring our work today.

www.abc.net.au/news/health/...

I'm looking forward to speaking at this exciting conference next year. If you're interested in the latest in microbiome research please check it out.

Early Life Antibiotics Put Vaccine Response at Risk While antibiotics given in the first week of life reduce vaccine responses at 15 months, probiotics might counteract these effects.

www.the-scientist.com/early-life-a...

Thanks @natrevimmunol.bsky.social for highlighting our recent @nature.com paper! @flindersuniversity.bsky.social @sahmri.bsky.social

Based on these findings we will soon start a randomised controlled trial to determine if a probiotic intervention can boost vaccine responses in infants that received antibiotics in the neonatal period. Funded by
@WCHFoundation

Very grateful to all our collaborators especially @HelenSMarshall and her team, the infants and their parents who participated in our study, our facilities incl @SA_genomics and the @sahmri.bsky.social
germ-free and flow facilities and our funders @nhmrc.bsky.social and the WCH Foundation

Neonates who received antibiotics had significantly lower antibody titres to multiple different vaccine antigens especially polysaccharides in the PCV13 vaccine.

Our paper out today in @nature.com shows the important role Bifidobacteria in the infant gut microbiota play in mediating optimal responses to vaccination.