Quantitative Proteomic Analysis Reveals JMJD6 and DNAJB11 as Endogenous Substrates of E3 Ligase RFFL The ubiquitin-proteasome system contributes to protein quality control, involving E3 ligases that ubiquitinate proteins and leading to their degradation. The dysregulation of protein degradation resul...

Congratulations to all the authors.

pubs.acs.org/doi/10.1021/...

Endosomal RFFL ubiquitin ligase regulates mitochondrial morphology by targeting mitofusin 2 Highlighted Article: The endosomal ubiquitin ligase RFFL associates with and primes mitochondria for PRKN recruitment, targets mitofusins for degradation and contributes to mitochondrial networks and ...

Recent publications from Prof. Murty Lab, IISER Thiruvananthapuram. Congratulations to all the authors

journals.biologists.com/jcs/article/...

#GRASP55 isn't just structural—it helps lysosomal enzymes get where they’re going. New research shows that knocking out GRASP55 leads to immature β-hexosaminidase A (HEXA) being misrouted and secreted instead of reaching the lysosome. www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology #Lysosomes

Do you want to hear the latest and greatest about the neuronal cytoskeleton? Join us in Chile next April for #NeuroCyto2025, organized by @monicamsousa.bsky.social, Kassandra Ori-McKenney and Tomás Falzone! Registration is open until March 5: neurocytoskeleton.com/2025/

Behind the scenes of cellular organization: Quantifying spatial phenotypes of puncta structures with statistical models including random fields | Molecular Biology of the Cell The cellular interior is a spatially complex environment shaped by non-trivial stochastic and biophysical processes. Within this complexity, spatial organizational principles–also called spatial pheno...

www.molbiolcell.org/doi/abs/10.1...

Poster presentation at ASCB|EMBO Cell Bio 24 conference at San Diego

Misinformation exploits outrage to spread online We tested a hypothesis that misinformation exploits outrage to spread online, examining generalizability across multiple platforms, time periods, and classifications of misinformation. Outrage is high...

Misinformation exploits outrage to spread online

www.science.org/doi/10.1126/...

Ångström-resolution fluorescence microscopy - Nature The authors introduce a single-molecule DNA-barcoding method, resolution enhancement by sequential imaging, that improves the resolution of fluorescence microscopy down to the Ångström scale using off...

ÅNGSTRÖM-RESOLUTION FLUORESCENCE MICROSCOPY.

Can we do structural biology with an optical microscope? Yes!

Check out how we resolved *single bases of DNA* and much more using fluorescence microscopy, out on 24.05.2023 in Nature! @natureportfolio.bsky.social

[re-post from Twitter]

Microscopy/live imaging people! Need your help 😅

I’ve only just recently started working with large time series files (1,000+ slices) and don’t know where to start when it comes to rendering and exporting them. What software(s) do you use?

🔬 Are you eager to dive into the world of light microscopy & learn from top-notch microscopists about its essential techniques for life science applications? If that sounds exciting, don’t miss out on this free, in-depth iBiology series! 👉 www.ibiology.org/online-biolo...

Pure autofluorescence from the midband crystalline cones in a mantis shrimp eye. The fluorescence comes from mycosporine like amino acid pigments that absorb specific bands of UV light, thus tuning the UV sensitivity of the photoreceptors they focus light into. 🧪

#FluorescenceFriday

TLR-mediated aggresome-like induced structures comprise antimicrobial peptides and attenuate intracellular bacterial survival | Molecular Biology of the Cell Immune cells employ diverse mechanisms for host defense. Macrophages, in response to TLR activation, assemble aggresome-like induced structures (ALIS). Our group has shown TLR4-signaling transcription...

Host cells take different kind of steps to fight infection. One such least understood intercellular structure is ALIS. Here Anushree et. al shows that ALIS indeed help in elimination of intracellular bacteria and also sequesters many anti-microbial peptides.

www.molbiolcell.org/doi/full/10....

Golgi is pretty interesting organelle. Its regulation by PTM like ubiquitination is also pretty cool. Here’s the recent paper from our lab, which shows involvement of endosome associated ubiquitin E3 ligase in maintaining Golgi architecture.

www.sciencedirect.com/science/arti...