This has such an impact on how we interpret our induction data doing physiology.
Cheers, Ole.

Thanks Christoph!
Way back in my mind there is this problem: when you induce a culture partially with whatever: do you then induce all cells partially or do you induce a fraction of cells to max and the rest are still repressed.

1/ 🔬 Our work, "Dynamic transitions of initiator binding coordinate the replication of the two chromosomes in Vibrio cholerae", is now published in Nature Communications.
Here's a thread on how we think Chr1 and Chr2 replication is coordinated in Vibrio. 🧵

Link : www.nature.com/articles/s41...

Kudos to
Justine Collier, Florian Fournés, and the others biorxiv.org/content/10.1... GREAT DISCOVERY : Agrobacterium controls its 2 chromosomes replication timing similarly to cholerae but with a COMPLETELY DIFFERENT SETUP.

I am particularly proud of this study from our laboratory, which explains how integrons have set up a kind of second-order selection. It reminds me of the time of the papiers on the selection of mutators to resist ABs. @FrancoisTaddei, Miro, Ivan, Jesus... www.science.org/doi/10.1126/...