@pritiagarwal.bsky.social, Zaidel-Bar et al. define the stage-specific gene expression programs of a leader cell that drives collective tissue invasion during organ #development, identifying membrane #trafficking as a central regulator of leader cell behavior. rupress.org/jcb/article/...

#Migration

Visiting with science trainees, I get asked a lot for advice, and I've landed on this as key for me:

Rather than worry about where life will take you– no matter where life takes you,

Aim to do good and do it well.

As to the “Where life will take you” question, only time will tell.

A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology Sun et al. develop a microscopy-based CRISPR screening platform that combines ease of implementation with flexible analysis of live-cell or antibody-based markers. Screens in human cells using a serie...

www.cell.com/developmenta...

Getting excited about the upcoming #centrosome conference in Lausanne!

Get your abstracts ready 👇

Amazing @epimechfc.bsky.social thread by @emmalaang.bsky.social !

Tissue mechanics and systemic signaling safeguard epithelial tissue against spindle misorientation Bosveld et al. identified a multilayered system of safeguards that reuses homeostatic mechanisms to maintain epithelial integrity and cell number in the face of spindle misorientation. This work delin...

How resilient are tissues to cell mispositioning and loss, and how do they restore their cell numbers?

Check our latest work, from @ybellaichelab.bsky.social
Congratulations to all authors.

Artwork from the artist @lale-alpar.bsky.social
(lalealpar.com)

www.cell.com/developmenta...

How do cells orchestrate themselves to achieve a directional movement as a group?

Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.

The EMBO Workshop "#Centrosomes: From fundamentals to diseases" in #Lausanne, Switzerland, 1–4 September 2026 will highlight the advances in the field of centrosome #research. Register now!

Deadline: 1 June

https://meetings.embo.org/event/26-centrosomes
#EMBOCentrosomes #EMBOevents #conference 🧪

Keeping up with the neighbours: local synchronisation of cell fate decisions during development - EMBO Reports Even before the advent of multicellular life, unicellular creatures would communicate with their neighbours to coordinate their behaviours. Multicellular organisms have the particular challenge of orc...

Hello, here is a review I wrote about how cells sometimes try to synchronise with surrounding cells so that they can do a good job of building tissues during development. It is called "Keeping up with the neighbours"

link.springer.com/article/10.1...

#DevBio 🧪

Also, not to forget the Iron Lady in its glory! :)

As the year ends, I recall this year's most memorable experience - the 16th Dev Bio International Course hosted jointly by @institutcurie.bsky.social and @sorbonne-universite.fr. Amazing talks by all the speakers. So grateful for the opportunity. Hoping the new year brings more! :)