Things that help calm the nervous system, quickly:
- Box breathing (in for 4, hold for 4, out for 4, hold for 4, repeat)
- Immerse your face in cold water (activates mammalian dive reflex)
- Humming (stimulates vagus nerve)
- Exercise (anything helps, outside even better)
- Impeachment and removal
Wow! This is so cool
*Neuroscience and philosophy*
Given the philosophical/conceptual naivete of all of neuroscience I will be retiring from my faculty position. I'm now looking for positions at philosophy departments and am happy to start at any level. I went from faculty to postdoc before and am ready again.
Lovely work on autoimmunity and its link to psychosis. I wonder what effect this modulation of NMDA receptors has on HALIPs? Less PPI would seem to be the opposite of a strong prior?
Overall, I am very grateful to EIC Dost Ongur for letting me write the paper I wanted to write! Feedback very welcome—I submitted a medium size personalize grant on this topic in the Netherlands now to do this 'HPCing' in large-scale data.
Hey friends, my new paper was just published in JAMA Psychiatry. I draw on biological species classification to sketch a new framework for psychiatric nosology.
Brief summary follows below.
Full text link: jamanetwork.com/journals/jam...
🧪 #PsychSciSky #MentalHealth
𝗛𝗼𝘄 𝗱𝗼 𝗯𝗿𝗮𝗶𝗻 𝗮𝗿𝗲𝗮𝘀 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝘁𝗼 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻?
"High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions."
Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones.
NB: study in the mouse
#neuroskyence
doi.org/10.1038/s415...
Please use full factorial designs in preclinical psychedelic research! I'm guilty of not doing so in the past, but it will be critical for understanding their MOA going forward. We need to be able to directly compare effects in pathology to those healthy organisms
Excellent interview... VERY interesting insights on stress vs mitochodrial energy balance. I wonder how much impact on stress adaptation can be gained by increasing mitochondrial resilience w keto/low carb/ Fasting and the right amount of Exercise stress (hiit, resistance trng)
I had a fantastic discussion about our Allostatic Triage Model of Psychopathology (ATP Model) and the potential mitochondrial and metabolic effects of psychedelics with @metabolicmind.bsky.social
Thanks so much for having me on!
Check er out:
youtu.be/-e49-DwCZ9A?...
Congrats @carmensandi10.bsky.social !!
Population norms. The average rate of neurodegenerative disease in the general population.
Posted the paper above
I posted the paper above
ADHD increases dementia risk, but the available epidemiological data suggests that stimulant medications may normalize risk. Totally fascinating
Thanks @hologramvin.bsky.social for this post! I did not know this so I hunted down the original paper:
jamanetwork.com/journals/jam...
Totally understandable and no worries at all. Thank you for the response. I’ll keep looking
Cool article. Not my field, so grain of salt, but regarding the cognitive benefits, I believe people need to take at least 5-10+ grams per day to significantly increase creatine concentrations in the brain, so you might not expect to see much change at the 3-5 grams/day recommended in the article.
Several others have now asked for references here too. Can you at least let us know where you heard this information so that I can try to track it down? I’m a scientist working partly in neurodegenerative diseases and I’m particularly curious about this question, and have been for some time
That’s really interesting. Do you have a reference for that study?
Metabolism is an energetic circuitry that transcends cellular and organellar boundaries
www.nature.com/articles/s42...
Afaik, midazolam is not antidepressant, (but it does induce acute amnesia), begging the question initiated by @theborislab.bsky.social here: pmc.ncbi.nlm.nih.gov/articles/PMC... : are these expectancy effects? you tell someone something will work, they have a drug experience and then feel better?
There are at least 2 kinds of active placebos: phenomenological and therapeutic placebos.. do they trick the participant because they feel similar to the active drug or bc they produce therapeutic effects? I am not aware of the antidepressant properties of benzos, so I assumed it was phenom placebo
Wait so midazolam is an antidepressant? Wut?
Hot off the press!
So many thanks to all of my mentors & co-authors for making this possible: @martinpicardenergy.bsky.social @thethrivelab.bsky.social @trpr-ucsf.bsky.social @parkersingleton.bsky.social @curiouslykaty.bsky.social, Gabriel Sturm, Ellen R. Bradley, Thomas Neylan, and Joseph Francis
The way we feel and the psychiatric symptoms some of us end up experiencing could emerge from the way energy flows, or fails to flow smoothly, in mitochondria.
The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro.bsky.social
www.sciencedirect.com/science/arti...
Altogether, we propose that extreme or chronic stress dysregulates mitochondria, affect, and allostatic triage, impairing allostasis, and driving transdiagnostic pathological states that, over time, become entrenched or "canalized" into pathological transdiagnostic disease phenotypes.
We propose that metabolic stress drives allostatic triage to stress-responsive networks that ensure short-term survival, like the salience network, from other networks including the central executive network that supports executive and goal-oriented functions, driving psychiatric symptoms
What happens when the brain cannot generate enough energy to handle stress?
Stress is metabolically expensive & all biology depends on finite energy resources, especially the CNS, which is the most expensive tissue in the body and has limited access to metabolic resources.