Early mitophagy defects and impaired mitochondrial energy metabolism drive target organ damage progression: lessons from the Fabry heart

www.biorxiv.org/content/10.6...

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️

biomed.news/bims-imicid/...

Lot's of exciting findings!

1) Purine salvage pathway protects CD8+ T cells from metabolic stress

2) Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells

Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

Last 2 weeks of research on #Mitochondria in #Health and #Disease! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

Among highlights 👇
www.nature.com/articles/s41...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

One of biggest mysteries in biology: how did complex eukaryotic cells evolve from simple microbes? ~1.8 billion years ago, an archaeal cell likely merged with a bacterium to form the first eukaryotic cell, but can we ever find direct evidence of this transformative event? 🦠 🚶‍♂️

UV irradiation alters TFAM binding specificity and compaction of DNA Independent experimental approaches demonstrate changes in TFAM binding to UVC-irradiated DNA, providing a potential mechanism for DNA damage sensing in the mitochondria.

UV irradiation alters TFAM binding specificity and compaction of DNA

elifesciences.org/articles/108...

MAP2K6 directly phosphorylates BCL2L13 to mediate mitophagy for suppressing tumorigenicity We discovered that MKK6 could localize to mitochondria and autophagosome and directly phosphorylate BCL2L13 at the S426 site, thereby elevating mitophagy, inhibiting OXPHOS, and preventing malignancy ...

MAP2K6 directly phosphorylates BCL2L13 to mediate mitophagy for suppressing tumorigenicity

www.cell.com/cell-reports...

📢last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

iNOS modulates inflammatory responses in an NO-independent manner through direct interaction with IRG1 in mitochondria.

4-year Phase III data for pegvaliase in adult PKU (Japan):

• ~70% ↓ phenylalanine
• Most achieve ≤360 µmol/L
• Diet liberalisation common
• AEs highest early, fall over time
• No new safety concerns

A useful long-term dataset.
doi.org/10.1002/jmd2...

Bridging nanomechanics and bioenergetics of single mitochondria by atomic force microscopy

www.life-science-alliance.org/content/9/5/...

Promotional image for the Mitogether consortium. The Mitogether logo appears at the top, with one letter stylized as a DNA helix. At the center, a scientific-style illustration of a transparent mitochondrion containing bright orange internal structures. At the bottom, the text reads ‘Consortium of French associations’ and ‘mitogether.com’.

𝐌𝐢𝐭𝐨𝐠𝐞𝐭𝐡𝐞𝐫.𝐜𝐨𝐦, 𝐚 𝐥𝐞𝐚𝐝𝐢𝐧𝐠 𝐰𝐞𝐛𝐬𝐢𝐭𝐞 𝐝𝐞𝐝𝐢𝐜𝐚𝐭𝐞𝐝 𝐭𝐨 𝐦𝐢𝐭𝐨𝐜𝐡𝐨𝐧𝐝𝐫𝐢𝐚𝐥 𝐝𝐢𝐬𝐞𝐚𝐬𝐞𝐬⁣

Launched by the French consortium MitoGether, it provides expert-validated and regularly updated information on mitochondrial diseases. A new essential resource for patients, physicians and Pharma. ⁣

mitogether.com

What if AI could invent enzymes that nature hasn’t seen? 👩‍🔬🧑‍🔬

Introducing 🪩 DISCO: Diffusion for Sequence-structure CO-design

📝 Blog: disco-design.github.io
📄 Paper: arxiv.org/abs/2604.05181
💻 Code: github.com/DISCO-design...

Metabolic profiling reveals pyrimidine synthesis enzyme CAD as a central carbon metabolism signaling node in cancer cell proliferation Qin et al. show that the pyrimidine synthesis enzyme CAD reprograms central carbon metabolism by deamidating G6PD and PHGDH, thereby fueling the formation of tumors, including hepatocarcinoma. Targeti...

Metabolic profiling reveals pyrimidine synthesis enzyme CAD as a central carbon metabolism signaling node in cancer cell proliferation

www.cell.com/molecular-ce...

Pleased to share our recent work out today in @natmetabolism.nature.com. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?

Excess cysteine drives conjugate formation and impairs proliferation of NRF2-activated cancer cells - Nature Metabolism Previously uncharacterized cysteine-derived conjugates, including with endogenous sugar metabolites, accumulate in cancer cells with constitutive NRF2 activation and account for some of the increased ...

Excess cysteine drives conjugate formation and impairs proliferation of NRF2-activated cancer cells

www.nature.com/articles/s42...

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

🚨New @lyssiotislab.bsky.social paper led by @radykm.bsky.social in @NatureMetabolism
"NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions"
🧵Follow for a tweetorial... and bonus highlight of Vousden Lab co-published study and News & Views link from Wellen Lab!

🌔 👋 The crew of NASA's Artemis II mission had some nice words for Earth as they regained communications with Mission Control. Watch with us: spklr.io/6001EyN07

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility

Pearling drives mitochondrial DNA nucleoid distribution The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...

Easter edition of #Mitochondria in #Health and #Disease!
🐰🐣
biomed.news/bims-mitdis/...

@gavinmcstay.bsky.social @mitoscientist.bsky.social @biomednews.bsky.social @mitoscientists.bsky.social

Perling drives mtDNA nucleoid distribution
www.science.org/doi/10.1126/...

Neural cell state modulation by PARK2 and dopaminergic neuroprotection by small molecule Parkin agonism

www.biorxiv.org/content/10.6...

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting new 'immunometabolism' method:

Single-cell assessment of iron content in primary human T cells using laser ablation inductively coupled plasma mass spectrometry

Big NIH policy change: no more “continuous submissions” for standing study section members @jeremymberg.bsky.social
grants.nih.gov/grants/guide...

Among the frustrating aspects of the funding situation in the U.S. is that the strategic response is to apply for more grants, with the result that the equilibrium success rate is pushed lower (up to a point). Scientists get less while spending more time writing grants rather than doing science.

a woman drinking a cup of coffee while reading a book with the name sophie on the bottom ALT: a woman drinking a cup of coffee while reading a book with the name sophie on the bottom

Weekly summary of the latest and greatest computational and analytical methods for metabolomics and lipidomics. Check it out!

biomed.news/bims-metlip/...

A collaboration with @biomednews.bsky.social

https://www.nature.com/articles/s42255-026-01476-1

Latest published research on #Mitochondria in #Health and #Disease! 📚 #week13
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

PLIN5 phosphorylation orchestrates mitochondria lipid-droplet coupling to control hepatic lipid flux and steatosis

Radiation-induced autophagy regulates fibroblast mitochondrial metabolism and crosstalk with triple-negative breast cancer cells Although radioresistant and circulating tumor cell survival has been attributed to altered metabolism, the metabolic impact of radiation therapy on stromal cells is unknown. Corn et al. demonstrate ra...

Radiation-induced autophagy regulates fibroblast mitochondrial metabolism and crosstalk with triple-negative breast cancer cells

www.cell.com/cell-reports...

🔬 Are you using the right antibody for your experiments?

Only Good Antibodies helps researchers identify specific antibodies

🧪 1496 antibodies against 147 proteins tested so far.

Check now
oga-website.onrender.com

OGA is powered by YCharOS

Random thought:
Science left academia long ago. What remains too often is politics, toxicity, bullying, and an endless race for impact factor.
#ucl #acdemia

Mitochondrial lactate venting limits oxidative stress The main function of mitochondria is to generate ATP by oxidizing pyruvate to CO2. Rauseo et al. show that matrix pyruvate is also converted to lactate, which is released to the cytosol via the MPC to...

Mitochondrial lactate venting limits oxidative stress

www.cell.com/cell-metabol...

Mitochondria packaged in blood cell membranes improve disease symptoms in mice Tiny capsules can deliver healthy organelles into animals with Parkinson’s-like and other mitochondria-linked disorders

Researchers say they have developed a new way to transplant healthy mitochondria into animals harboring defective versions—a strategy the team hopes could one day treat certain neurodegenerative disorders and inherited genetic diseases in people. https://scim.ag/4uND3mi