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Posts by Mohamady El-Gaby

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AiN summer school equips you with the essential tools and knowledge to explore the brain through the lens of computers and algorithms. Whether you're a neuroscience enthusiast or a programming wizard, this program empowers you to understand the mind's complex workings through the power of code.

This is a great opportunity for all Arabic speakers intersted in computational neuroscience - The Introduction to Computational Neuroscience Online School. The whole thing is in Arabic, fully free and TAs are paid. Deadline in 3 days!
More here: arabsinneuro.org/school/

5 days ago 1 3 0 0

The world watched as Israel razed Gaza to the ground.

Now, the world is watching as Israel razes Lebanon to the ground.

War crimes beget war crimes — and the failure to bring Israel to justice for genocide has emboldened it to destroy human life with total impunity.

6 days ago 2622 1036 118 42
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Protect Academic Life in Iran We, the undersigned academics and researchers from around the world, express our profound concern over recent military strikes on Iran, the retaliatory responses, and the reported impact on civilian l...

Academic friends,
It's beyond heartbreaking to watch what's unfolding in Iran & the region.
A few of us drafted an open letter calling for protection of civilians & of educational, research, medical & cultural institutions.

Please read & sign if you agree:
sites.google.com/view/protect...

#IranWar

1 week ago 83 51 2 2
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Israel says it will keep control over part of southern Lebanon after war with Hezbollah ends Defence Minister Israel Katz also says houses in Lebanese villages near the Israeli border will be demolished.

If racism was a country: www.bbc.co.uk/news/article...
“In addition, the return of more than 600,000 residents of southern Lebanon who evacuated northward will be completely prohibited south of the Litani until the safety and security of northern (Israeli) residents are ensured”

2 weeks ago 8 2 0 0
Graphical abstract showing that NMDAR immunisation drives psychosis-like behaviour in mice, while clozapine reverses this. Upper panel: arrows show NMDAR immunisation producing a mouse exhibiting psychosis-like behaviour, with clozapine reversing this effect. Lower panels: anti-NMDAR antibodies bind neuronal NMDA receptors, which are then eliminated by microglia via phagocytosis, leading to psychosis. Clozapine restores NMDA receptor levels by reducing anti-NMDAR antibody levels, consistent with an immunomodulatory mechanism of action.

Graphical abstract showing that NMDAR immunisation drives psychosis-like behaviour in mice, while clozapine reverses this. Upper panel: arrows show NMDAR immunisation producing a mouse exhibiting psychosis-like behaviour, with clozapine reversing this effect. Lower panels: anti-NMDAR antibodies bind neuronal NMDA receptors, which are then eliminated by microglia via phagocytosis, leading to psychosis. Clozapine restores NMDA receptor levels by reducing anti-NMDAR antibody levels, consistent with an immunomodulatory mechanism of action.

🥁🎉The Psychosis Collective proudly presents our first preprint

𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞

𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴

starring Le He & Harriet Feldman

www.biorxiv.org/content/10.6...

We wanted to understand how antipsychotics work. Thread🧵

2 weeks ago 78 33 3 6
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A cognitive map for value-guided choice in the ventromedial prefrontal cortex Value-based decision-making can be conceptualized as navigation within a cognitive map of choice values. During choice, the ventromedial prefrontal cortex (vmPFC) compositionally builds cognitive maps...

1/n

With Cosyne around the corner, I thought I would:

a) make a thread about our “A cognitive map for value-guided choice in the vmPFC” Cell paper (i'm a bit late). shorturl.at/DBA3H

1 month ago 39 11 1 4

It's Cosyne time!!

Here are some contributions from my lab and some of my close collaborator labs (Thomas Akam, @melgaby.bsky.social, Steve Kennerley, @sameershethmd.bsky.social )

1 month ago 31 5 1 1
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At #cosyne2026? Check out Sumedha Nalluru’s poster from our lab! Showing that reduced cortical inhibition causes false associations. Friday 13th March from 1:15 - 4:15pm.

1 month ago 9 2 1 1
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Looking forward to :)

1 month ago 0 0 0 0

This is a game changer. Even structures as complex as a torus can be innate.

1 month ago 9 1 1 0
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All of these posters feature nods to a framework we call duplicated structured representations (DSRs) that seems to unify a broad swathe of PFC data and make cool new predictions. Watch this and @kristorpjensen.bsky.social ‘s space for more on this over the coming year! 6/6

1 month ago 3 1 0 0
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@mathiassablemeyer.bsky.social is taking these ideas one step further and showing how a hierarchical structure can be encoded in MEG activity from humans performing nested sequences. This work elegantly rules in/out different models of hierarchical coding! 5/6

1 month ago 2 1 1 0
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I also want to highlight awesome work from friends in the Behrens lab. @skuechenhoff.bsky.social is finding both fMRI and single unit evidence for two different ways of encoding task progress in the human PFC and MTL! 4/6

1 month ago 1 0 1 0
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Mingyu is asking how these goal progress signals come about in the first place. Turns out ventral hippocampus and PFC interactions might be critical for this. A tour de force of simultaneous hippocampus-PFC neuropixels recordings and optogenetic silencing! 3/6

1 month ago 1 0 1 0
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Adam will show how neurons in the mouse PFC, and both medial and lateral Entorhinal cortices compare when it comes to encoding goal and task progress and how this relates to space and time. Featuring 100s of simultaneously recorded LEC neurons! 2/6

1 month ago 1 0 1 0
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First Cosyne for the Mind Mechanisms lab!
We’re broadly interested in world and goal models in the PFC and temporal lobe. Come chat to @adamloydharris.bsky.social and Mingyu Zhu as they present some new findings tomorrow (Thursday) evening. #Cosyne2026 …🧵 1/6

1 month ago 13 3 2 0
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Excited to see this Version Of Record of my work out in @elife.bsky.social!
elifesciences.org/articles/106...
We investigate the mental representation of geometric shapes in adults and children using fMRI and MEG. Each figure has a video of me explaining the figure: go and read it, or read below.

2 months ago 42 15 1 3
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Neuronal spiking in the mammalian forebrain is dominated by a heterogeneous ground state Neuronal firing patterns have significant spatiotemporal variability with no agreed-upon theoretical framework. Using a combined experimental and mode…

With this one in print, I think I finally earned that PhD... 😅
Presented for the first time at the cosyne when the world ended (March 2020). I'll bring over a summary thread from twitter when it was still twitter...

www.sciencedirect.com/science/arti...

2 months ago 147 38 10 1

A must read for anyone interested in the social brain.

2 months ago 2 0 0 0

We review studies showing that when brain areas face similar computational demands in social and non-social context, they perform the same computations. We argue that exaptation (repurposing of traits for new functions) played a key role in brain evolution.

2 months ago 52 18 0 1

Thrilled to finally share this work! 🧠🔊

Using a new reinforcement-free task we show mice (like humans) extract abstract structure from sound (unsupervised) & dCA1 is causally required by building factorised, orthogonal subspaces of abstract rules.

Led by Dammy Onih!
www.biorxiv.org/content/10.6...

2 months ago 155 52 3 2
Will's Wild Website

Cosyne Viewing Parties

Visas, costs, care responsibilities, and environmental concerns all limit Cosyne attendance. Luckily, the talks are livestreamed; but watching alone is the high road to an aneurism. Hence: viewing parties! Gather regionally to watch Cosyne talks! More info: shorturl.at/3DHZX.

2 months ago 15 9 0 0
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Hybrid neural–cognitive models reveal how memory shapes human reward learning - Nature Human Behaviour Using artificial neural networks applied to human data, Eckstein et al. show that good models of reinforcement learning require memory components that track representations of the past.

Hybrid neural–cognitive models reveal how memory shapes human reward learning
www.nature.com/articles/s41...

2 months ago 18 4 1 0

New discovery! Value-based decisions reorganize neural state space. Options are first encoded in orthogonal subspaces Then the selected option rotates into a "readout subspace".
Neural subspace reorganization reflects value-based decision making.
www.biorxiv.org/content/10.6...
#neuroscience

2 months ago 45 12 1 0
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*Multi-region computations in the brain*
When two regions are better than one...
doi.org/10.1016/j.ne...
#neuroskyence

2 months ago 51 14 2 0
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It’s PhD defence season. Here is a short guide on how to ace these.

4 months ago 5 0 0 0
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The hippocampus is not a library, it is a simulation engine.

HPC is known for storing maps of the environment but not so known for generating planned trajectories.

This paper proposes that recurrence in CA3 is crucial for planning.

A🧵with my toy model and notes:

#neuroskyence #compneuro #NeuroAI

4 months ago 56 19 4 1

Do you need your toes to think?

YESS!

Happy to see this one out 😎!

From your humble toes to your noble neurons, you need all your cells to solve your most important problem :

How to stay alive 😎😅

4 months ago 49 12 4 1

Elena Gutierrez , @sandra-neuro.bsky.social and @mathiassablemeyer.bsky.social

4 months ago 0 0 0 0

If you attended our SfN symposium on cognitive maps in the PFC then here’s a recap of what was covered. If you didn’t then here’s what you missed! TLDR: converging evidence for structured representations of the world and task in the PFC in humans NHPs and rodents. Led by @sebves.bsky.social and…

4 months ago 6 0 1 0