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Posts by Josephine Flockton

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Genetic signature of ADHD linked to the brain's timing signals | King's College London Genetic variation linked to ADHD manifests directly through disrupted timing in the brain’s cognitive control systems.

What can disrupted timing in brain signals tell us about it's cognitive control systems and #ADHD?

New research has found that polygenic scores for ADHD can predict irregularities from the frontal areas of the brain.

Click the link to learn more👇

#IoPPNNews

bit.ly/48eDfRT

1 day ago 6 3 0 0
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Successful closed-loop neurofeedback alpha frequency modulation enhances the temporal dynamics of attention Efficient attention depends on the temporal alignment between ongoing neural activity and task-relevant sensory events. Alpha-band dynamics, and parti…

Increasing IAF via NF enhances attention & speeds up alpha-ERD onset www.sciencedirect.com/science/arti...

Cool convergence in recent alpha work; frequency setting the timing of cortical engagement in attention, and power relating to how well info is represented + whether it's accessed in memory 🌊

2 days ago 1 0 0 0
The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across brain states. However, studies supporting these views have measured neural activity as a bulk quantity and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume across the mouse brain, and find that their relationship is consistent across brain states and brain regions but differs in two opposing brainwide neural populations. Functional ultrasound imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings showed that neurons that increase activity with whisking have distinct haemodynamic response functions compared with those that decrease activity. Their summed contributions predicted blood volume across states.Brainwide Neuropixels recordings revealed that these opposing populations coexist in the entire brain. Their differing contributions to blood volume largely explain the apparent differences in blood volume fluctuations across regions. The mouse brain thus contains two neural populations with opposite relations to brain state and distinct relationships to blood supply, which together account for brainwide fluctuations in blood volume.

The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across brain states. However, studies supporting these views have measured neural activity as a bulk quantity and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume across the mouse brain, and find that their relationship is consistent across brain states and brain regions but differs in two opposing brainwide neural populations. Functional ultrasound imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings showed that neurons that increase activity with whisking have distinct haemodynamic response functions compared with those that decrease activity. Their summed contributions predicted blood volume across states.Brainwide Neuropixels recordings revealed that these opposing populations coexist in the entire brain. Their differing contributions to blood volume largely explain the apparent differences in blood volume fluctuations across regions. The mouse brain thus contains two neural populations with opposite relations to brain state and distinct relationships to blood supply, which together account for brainwide fluctuations in blood volume.

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states!

Out today in Nature: rdcu.be/fdC2A

@uclbrainscience.bsky.social

5 days ago 142 62 4 6
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Do Machines Fail Like Humans? A Human-Centred Out-of-Distribution Spectrum for Mapping Error Alignment Determining whether AI systems process information similarly to humans is central to cognitive science and trustworthy AI. While modern AI models can match human accuracy on standard tasks, such parit...

Excited to share our new preprint: "Do Machines Fail Like Humans? A Human-Centered Out-of-Distribution Spectrum for Mapping Error Alignment" led by
@binxia.bsky.social w @ken-lxl.bsky.social & co-senior author Luke Dickens (UCL)
🤖🧵👇
Link: arxiv.org/abs/2603.07462
🧠📈#PsychSciSky #compneuro #mlsky /1

1 week ago 32 17 3 4

Evidence for predictive computations in a brain hierarchy during a visual search task www.biorxiv.org/content/10.64898/2026.04...

1 week ago 4 3 1 0
Respiration as a dynamic modulator of sensory sampling Nature Communications - Breathing shapes perception: Inspiration upregulates arousal and excitability, sharpening sensitivity to visual signals. By aligning respiration with task timing, people...

Out now in @natcomms.nature.com, our latest from @bodybrainbehaviour.bsky.social: Visual perception, oscillatory excitability markers, and network connectivity are modulated by the breathing rhythm - depending on how much you know about the stimulus.

#brainbody #neuroskyence

1 week ago 45 17 0 1

🚨New preprint🚨
Very excited about the last work led by Dugué Lab PhD student Yue Kong on TMS-induced #traveling_waves.

@erc.europa.eu
@upcite.bsky.social

www.biorxiv.org/content/10.6...

1 week ago 17 5 1 0
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No Effects of Predictability on Word-Meaning Priming and Incidental Memory | Journal of Cognition

My first first-author paper has just been published @JCgntn: doi.org/10.5334/joc.... - check it out below if you’re interested in prediction and/or word-meaning priming! ⬇️

Big thanks to my amazing co-authors/supervisors @mggaskell.bsky.social, @sacairney.bsky.social, @matthewmakpsy.bsky.social

2 weeks ago 14 4 1 0

Help I'm addicted

3 weeks ago 0 0 0 0
  Graphical abstract showing three panels. Left panel, "Multiorgan Interoception Measures," depicts a translucent human body
   silhouette with anatomically rendered heart (red) and lungs (blue), accompanied by schematic icons for three
  psychophysical tasks: the Respiratory Resistance Sensitivity Task (RRST), Heart Rate Discrimination Task (HRDT), and an
  auditory control condition. N = 241 participants. Center panel, "Psychophysical Modelling and Individual Differences,"
  shows a fan of overlapping sigmoid psychometric curves in blue-to-red gradient representing individual variation in
  perceptual threshold (α) and precision (β), a hierarchical Bayesian model diagram, and icons for metacognitive bias and
  M-Ratio efficiency. Right panel, "Key Finding: No Cross-Modal Relationship," displays a scatterplot of cardiac versus
  respiratory sensitivity with a flat regression line (r ≈ 0, BF₀₁ > 6), a compact Bayes Factor heatmap with mostly blue
  null-supporting cells and one orange cell indicating that subjective confidence is shared across modalities (r = 0.51***).
   Takeaway: interoceptive ability is modality-specific.

Graphical abstract showing three panels. Left panel, "Multiorgan Interoception Measures," depicts a translucent human body silhouette with anatomically rendered heart (red) and lungs (blue), accompanied by schematic icons for three psychophysical tasks: the Respiratory Resistance Sensitivity Task (RRST), Heart Rate Discrimination Task (HRDT), and an auditory control condition. N = 241 participants. Center panel, "Psychophysical Modelling and Individual Differences," shows a fan of overlapping sigmoid psychometric curves in blue-to-red gradient representing individual variation in perceptual threshold (α) and precision (β), a hierarchical Bayesian model diagram, and icons for metacognitive bias and M-Ratio efficiency. Right panel, "Key Finding: No Cross-Modal Relationship," displays a scatterplot of cardiac versus respiratory sensitivity with a flat regression line (r ≈ 0, BF₀₁ > 6), a compact Bayes Factor heatmap with mostly blue null-supporting cells and one orange cell indicating that subjective confidence is shared across modalities (r = 0.51***). Takeaway: interoceptive ability is modality-specific.

Is there a single "interoceptive sense"? Our new study in
@commspsychol.nature.com says: probably not. In 241 participants, cardiac and respiratory interoception were completely uncorrelated — only subjective confidence was shared across domains. www.nature.com/articles/s44... #psychscisky 🧪

1 month ago 115 31 2 5
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New paper in Imaging Neuroscience by George M. Opie, Ulf Ziemann, et al:

Diazepam alters the shape of alpha oscillations recorded from human cortex using EEG

doi.org/10.1162/IMAG...

1 month ago 17 6 0 1

It's been interesting to think about this very cool paper in the context of @darya-frank.bsky.social's work on how sensitivity to novelty & expectation violations relates to strengthening of episodic memories in superagers - after hearing her awesome talk this week @yorkpsychology.bsky.social 🧠

1 month ago 5 1 0 0

Consciousness is just a skill issue. I haven't had subjective experience since I started using Claude Code

1 month ago 54 7 1 1

Temporally-precise sensory encoding of predicted content, entraining motor oscillations to derive time. @akalt.bsky.social's first study out @currentbiology.bsky.social, testing parts of this idea (tinyurl.com/TiCSKaltenma...). Huge thanks @leverhulme.ac.uk ac.uk @erc.europa.eu, great work Aaron!

1 month ago 38 15 0 0

Functionally heterogeneous waveform morphology strikes again and I'm so here for it, lovely work 💥 🌊

1 month ago 2 0 0 0

Distinct beta burst motifs exhibit opposing error relationships during motor adaptation www.biorxiv.org/content/10.64898/2026.03...

1 month ago 7 3 0 0
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Episodic memory encoding fluctuates at a theta rhythm of 3–10 Hz Nature Human Behaviour - Biba et al. show that episodic memory encoding fluctuates at a theta rhythm of 3–10 Hz.

I am excited to share my first paper, showing that episodic memory formation is theta rhythmic, is now published in Nature Human Behavior! Check it out here: rdcu.be/e6pzS. Thanks to my PI, Katherine Duncan, and to my collaborators for their support on this journey! Stay tuned for iEEG follow up 🧠

1 month ago 119 46 3 3

Thanks Emma, happy to join the international postdoc club with you! 🦘 🥨

1 month ago 1 0 0 0

Thank you Catherine! 🍾

1 month ago 1 0 0 0
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Thank you! 😊

1 month ago 0 0 0 0

Delighted to share that I'll begin a postdoc in Tübingen this year 🇩🇪 on @joelfrohlich.bsky.social's exciting FETAL-MIND project; using fMEG & OPM to investigate neural responses to sensory and social stimuli, in the fetal brain! 🧠

1 month ago 17 1 3 0

How dynamics arise from the structure is my biggest interest. In this study, we started with a small step and asked how structure constrains dynamics. Spoiler: would that it were so simple… (1/6)

1 month ago 32 23 1 2
cool people, follow them!

cool people, follow them!

I built a bluesky labeler for neuroscience methods.

1️⃣ follow/subscribe to: @neuromethods.bsky.social
2️⃣ like the post with your favorite method
➡️ get a shiny methods label in your profile/posts. 🌟

1 month ago 45 25 2 1
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Delayed, Reduced and Redundant: Information Processing of Prediction Errors during Human Sleep During sleep, the human brain transitions to a ‘sentinel processing mode’, enabling the continued processing of environmental stimuli despite the absence of consciousness. We employed advanced informa...

Delayed, Reduced and Redundant: Information Processing of Prediction Errors during Human Sleep

www.jneurosci.org/content/earl...

#neuroskyence

1 month ago 12 3 0 1

its amazing how chatgpt knows everything about subjects I know nothing about, but is wrong like 40% of the time in things im an expert on. not going to think about this any further

1 year ago 18847 4604 127 154

📡🧠New preprint: check out our purpose-built OPMEG-compatible VR goggles and their validation with several cognitive tasks. Towards naturalistic human neuroscience. Read more here: www.biorxiv.org/content/10.6...

#naturalisticneuroscience #neuroimaging #opm #opmeg

2 months ago 4 1 0 0

Thrilled to share this work, spearheaded by the Danc lab (led by James Bonaiuto) @danclab.bsky.social, in collaboration with us, especially Matteo Maspoli @mattgmasp.bsky.social and Danila Shelepenkov @shpen.bsky.social, and other groups who share the belief that MEG still has untapped potential!

2 months ago 9 8 0 0
Jobs - The University of York

Job alert!!

We're looking for a Postdoc and two RAs on a 3-year project examining the effects of smartphones on sleep and mental health in adolescents. Details below:

RA: tinyurl.com/7h6zrz2k
Postdoc: tinyurl.com/ykmsk757

Please repost :)

2 months ago 11 17 0 0
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Soon hiring a lab manager! Looking for someone who is really interested in language neuroscience, who is organised, motivated, a great communicator, and who works well in a research team. Express interest by submitting this form: tinyurl.com/glysn-labman...

Reposts appreciated!

2 months ago 41 39 3 1
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The Human Insula Reimagined: Single Neurons Respond to Simple Sounds during Passive Listening The insula is critical for integrating sensory information from the body with that arising from the environment. Although previous studies suggested that posterior insula is sensitive to sounds, these...

"The Human Insula Reimagined: Single Neurons Respond to Simple Sounds during Passive Listening"

Single neuron activity in the insula
#iEEG

in #JNeurosci @sfnjournals.bsky.social

www.jneurosci.org/content/46/4...

2 months ago 14 4 0 0