#VisualAbstract Blood and urine biomarker signatures in sepsis were linked to 90-day mortality and subtype membership. zurl.co/xeXNA

Interested in the major trials in critical care?

We have summarised and critiqued 250 of the most important randomised controlled trials stretching back over the past 25 years.

criticalcarereviews.com/collections/foundational...

Pulmonary Function Decline in Very Early Diagnosis of Systemic Sclerosis: A Retrospective Longitudinal Single-Center Study. Graphical abstract created using BioRender

Retrospective study of 73 patients with very early dx of SSc showed over 5-year follow-up that baseline DLco/single breath % <70% was assoc. with progression toward definite SSc and shorter time to transition; however, decline could also occur without transition to SSc

ACROR
doi.org/10.1002/acr2...

Bedside identification of subphenotypes in acute respiratory failure (PHIND): a multicentre, observational cohort study

CCR Journal Watch
criticalcarereviews.com/latest-evidence/journal-...

Procalcitonin testing combined with NEWS2 evaluation compared with usual care based on NEWS2 for identification of sepsis and antibiotic initiation in the emergency department (PRONTO): a multicentre, open-label, phase 3 RCT

CCR Journal Watch
criticalcarereviews.com/latest-evide...

Computed tomography demonstrated the recurrence of multiple bilateral pulmonary nodules and masses (A). Follow-up CT in 2024 showed excavation of the nodules into thick-walled cavities with air-fluid levels (B). By 2025, under maintenance rituximab therapy, these cavities collapsed and regressed, leaving only residual parenchymal scarring (C)

Clinical images in ACROR show progression and resolution of GPA with pulmonary involvement
doi.org/10.1002/acr2...

2022: A 59-year-old man presents with fever, conjunctival injection, & sensorineural hearing loss. Dx with GPA; started on GC and IV CYC

continues ↓

Functional recovery after critical illness in older ICU survivors varies by age and baseline function, with nationwide German data showing higher risks of decline and death for survivors aged 60–89 years compared with matched peers. zurl.co/PNOXg

New in the March 12/19, 2026, issue of NEJM:

Bleeding Risk with Apixaban vs. Rivaroxaban in Acute VTE (COBRRA trial) nej.md/4lp5N0d

Romiplostim for Chemotherapy-Induced Thrombocytopenia (phase 3 RECITE trial) nej.md/40rIYzG

⭐ ICMx 2025 Recap #VisualAbstract

Machine learning-based identification of efficient and restrictive physiological subphenotypes in acute respiratory distress syndrome

doi.org/10.1186/s40635-025-00737-9

AKRiS: An Accurate Tool for Predicting Long-Term Risk for Renal Failure in AAV The Improved ANCA Kidney Risk Score (AKRiS) was best able to differentiate long-term risk for renal failure across all categories, per new research.

Kaplan-Meier analysis demonstrated statistically significant differences among the 4 risk categories with use of the Improved #ANCA Kidney Risk Score (P <.001). @senefrologia.bsky.social

Read more: https://bit.ly/4rfRzAo

#RareDisease #MedSky

Hey ChatGPT, write me a fictional paper: these LLMs are willing to commit academic fraud Mainstream chatbots presented varying levels of resistance to deliberate requests for fabrication, study finds.

The findings “should act as a wake-up call to developers on how easy it is to use LLMs to produce misleading and low-quality scientific research”

go.nature.com/4u4SBBP

Today's Paper of the Day is:

Haemophagocytic lymphohistiocytosis in critical care

Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2026

Link in bio

Weekly recap in ACR Journals banner - ACR Open Rheumatology

Online this week in ACR Open Rheumatology:

Serum cytokine profiles of patients with MDA5+ DM-ILD treated with JAKi
doi.org/10.1002/acr2...

Discordance in reported lupus burden between patients and physicians involved in lupus care
doi.org/10.1002/acr2...

A diagram titled, "Figure 1. Intravascular Volume Overload," shows a human torso with lungs and the words "Pulmonary edema," "Jugular vein distention," and "Inferior vena cava distention." Additional flowcharts detail decreased cardiac output and arterial underfilling.

How can volume overload be reliably excluded at the bedside?

📊 This Rational Clinical Examination evaluates the diagnostic accuracy of clinical examination, radiographic imaging, and laboratory testing in assessing volume overload in nonintubated patients.

ja.ma/4rHKaKU

Infographic about microplastics. It defines microplastics as fragments from plastic litter that contain toxic chemicals. It shows a woman drinking water from a plastic bottle, with a baby in her arms, and includes a close-up of a microplastic fragment containing bacteria.

#Microplastics are plastic fragments smaller than 5 mm that results from breakdown of plastic litter.

📄 This JAMA Patient Page describes microplastics and the potential health effects of human exposure to microplastics.

ja.ma/3OD9tiF

Physiology-guided personalized mechanical ventilation to prevent ventilator-induced lung injury

CCR Journal Watch
criticalcarereviews.com/latest-evidence/journal-...

#ILD 🫁 and #ANCA #AAV 👌

Diagnostic radiologique d’une pneumopathie interstitielle Les pneumopathies interstitielles diffuses (PID) constituent un groupe complexe et hétérogène de pathologies pulmonaires, dont le diagnostic repose su…

Bel article à propos du diagnostic radiologique d’une PID par @revmedinterne.bsky.social ! 🫁 💡 ⭐️ ⭐️ ⭐️

www.sciencedirect.com/science/arti...

Kittredge Lecture: Pulse Oximetry Facts and Fallacies

CCR Journal Watch
criticalcarereviews.com/latest-evidence/journal-...

This is figure three, which shows different microscopy modalities for in vivo imaging of the immune system.

Immune interactions are complex, dynamic and difficult to capture using static imaging modalities on in vitro or ex vivo tissue cultures. A Review in Nature Reviews Bioengineering discusses techniques for in vivo imaging of the immune system. go.nature.com/4qR4eKI 🔒

An illustrated diagram of the causes of cardiogenic shock

Causes of cardiogenic shock can be categorized according to etiologic factors: acute myocardial infarction; factors unrelated to myocardial infarction, such as new or acute-on-chronic heart failure; or secondary nonmyocardial causes and postcardiotomy shock. Learn more: nej.md/49ohKyV

🌿 💊 🌿 Article récent dans Haematologica Journal visant à comparer l'impact carbone des 3 AOD utilisés en France.
Une perspective environnementale pour aider le clinicien dans ses choix !

Utilisation des données d'ECOVAMED, qui analyse l'empreinte carbone et les cycles de vie des produits de santé.

Today's Paper of the Day is:

Imaging the Lung in ARDS: A Primer

criticalcarereviews.com/latest-evidence/paper-of...

Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025

Current Pharmacological and Non-Pharmacological Decongestion Strategies in Acute Heart Failure - Evidence and Practical Guidance

CCR Journal Watch
criticalcarereviews.com/latest-evidence/journal-...

🚨 🫁 ILD +++

Today's Paper of the Day is:

Diagnosis and management of autoimmune diseases in the ICU

criticalcarereviews.com/latest-evidence/paper-of...

Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025

Today's Paper of the Day is:

Recent advances of precision immunotherapy in sepsis

criticalcarereviews.com/latest-evidence/paper-of...

Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025

Today's Paper of the Day is:

Vasopressin and its analogues in patients with septic shock: holy Grail or unfulfilled promise?

criticalcarereviews.com/latest-evide...

Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025

👍 Cette semaine marquait le 90e congrès de la SNFMI - Société Nationale Française de Médecine Interne à Vichy (France) ! | Romain Batton 👍 Cette semaine marquait le 90e congrès de la SNFMI - Société Nationale Française de Médecine Interne à Vichy (France) ! L&#39;opportunité de presenter 2 travaux issus de mon travail de thèse pour le ...

#SNFMI2025 was this week in Vichy, France 🇫🇷 ☀️

www.linkedin.com/posts/romain...

🙌Thank you for attending the #EULAR2025 Congress!
We hope you had a memorable experience!

📺Access the On-demand Congress Platform until 31 December 2025 👉 https://pulse.ly/vl0sg17x4k

✈️We Look forward to seeing you at #EULAR2026 in London!

#EULAR #EULAR2025 #Rheumatology