Structural insights into clonal restriction and diversity in T cell recognition of two immunodominant SARS-CoV-2 nucleocapsid epitopes @natcomms.nature.com
www.nature.com/articles/s41...
OpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇
Left to right: CMNS Dean Amitabh Varshney, Rui Yin, CBMG Associate Professor Brian Pierce
Rui Yin (Ph.D. '24, biological sciences) uses #ArtificialIntelligence to design antibodies that can cure previously incurable diseases.
During her Ph.D. at #UMD, Rui developed and applied computer algorithms to better understand the body’s immune response to pathogens and disease ➡️ go.umd.edu/yin
Foldseek-Multimer—now published in @naturemethods.bsky.social—our fast multimer search tool, enables complex comparisons against the full PDB in seconds. It comes with BFMD, a collection of 300K+ predictions gathered from community projects.
📄 nature.com/articles/s41...
🌐 search.foldseek.com
#AlphaFold 2 (via TCRmodel2) and AlphaFold3 were both tested for modeling of these new complex structures, and both were able to model them accurately. However, modeling of additionally structurally uncharacterized complexes led to low confidence scores, indicating room for improvement.
Happy to share this collaborative study with the Mariuzza Lab on structural characterization of #TCR engagement of NRAS cancer neoantigens, now out in Science Advances. This reveals how a human TCR is able to productively engage two different NRAS mutants.
www.science.org/doi/10.1126/...