Well this might help differentiate between iatrogenic and sporadic CAA - especially important in older people - and then why deep pathology? Subtle inflammation? Do we need a closer look at sporadic CAA?

V grateful to patients who share their stories, making these steps forward possible 🙏🏽 … 2/2 🧵

Clinical-radiological presentation and natural history of iatrogenic cerebral amyloid angiopathy Background We aimed to describe neuroimaging features, clinical profiles and long-term outcomes in patients with iatrogenic cerebral amyloid angiopathy (iCAA). Methods We performed a systematic liter...

New in JNNP - the next chapter in the story of iatrogenic CAA 📕 and it really does seem to be different to sporadic CAA. Presence of deep haemorrhagic pathology in particular is unexpected but persistent signal.

So what does this mean? … 1/2🧵

jnnp.bmj.com/content/earl...

Patient-Reported Nonmotor Outcomes After Stroke This systematic review and meta-analysis evaluates the prevalence, natural history, and factors associated with multidomain nonmotor outcome burden in patients with stroke.

It’s certainly the most comprehensive meta-analysis I’ve ever been involved with 🤓

TLDR: non-motor symptoms after stroke are common across domains and guess what? Not a great deal has changed in the last decade. A real wake up call to the field to address this huge unmet need

ja.ma/3EMdegV

So is it inflammation rather than acute cSAH that drives TFNE?🐔vs🥚but anatomical localisation of inflammation with symptoms is v. interesting... and then should we be treating TFNE with steroids?? 🤔

Seems there's more inflammation in regular CAA than we ever suspected... 2/2

Inflammation in Cerebral Amyloid Angiopathy‐Related Transient Focal Neurological Episodes Transient focal neurological episodes (TFNE), often associated with convexity subarachnoid hemorrhage (cSAH), are common in cerebral amyloid angiopathy (CAA), but their pathophysiology remains incomp....

We tend to think of CAA-related inflammation as its own separate thing - but is this right?

@AminaSellimi @UCLStrokeRes et al have found inflammation in people with prolonged TFNE (amyloid spells) - even though they all had "non-inflammatory" CAA... 1/2

onlinelibrary.wiley.com/doi/10.1002/...

Misty walk earlier today

Why is this important and/or relevant?

(1) Not all patients with CAA-ri have classical white matter changes, so these features could support diagnosis;

(2) This could help CAA-ri be diagnosed (and treated) earlier, winding back the clock for defining "early" CAA-ri ⏰

…2/2

Sulcal Hyperintensity as an Early Imaging Finding in Cerebral Amyloid Angiopathy–Related Inflammation | Neurology Background and ObjectivesCerebral amyloid angiopathy–related inflammation (CAA-ri) is a subtype of CAA with distinct clinical and radiologic features. Existing diagnostic criteria require the presence...

We define CAA-ri by classical (asymmetrical, waxing/waning) white matter changes - this paper, new from the UCL Stroke Research Centre, describes imaging features of inflammation in CAA-ri that appear *before* these white matter changes ...1/2

www.neurology.org/doi/10.1212/...

Stretching my legs after an intense morning of writing