Job Opportunity at University of Leeds: Lecturer in Neuroscience Salary: Grade 8 (£51,753 – £59,966 p.a.)This role will be based on the university campus, with scope for it to be undertaken in a hybrid manner. We are also open to discussing flexible working arrange...

📣 Looking to set up your own neuroscience🧠🧪 lab? We have a lectureship position available at the University of Leeds. 🚀
jobs.leeds.ac.uk/vacancy.aspx...

Excellent Leeds Neuroclub and pizzas on Friday 🧪🧠

🚀 We’re recruiting! A fully funded PhD position is available in our lab. 🧠🧪
Curious? Get in touch, I’d be happy to discuss. phd.leeds.ac.uk/project/2471...

Isotonic and minimally invasive optical clearing media for live cell imaging ex vivo and in vivo - Nature Methods SeeDB-Live is a tissue-clearing approach for live samples such as tissue slices or the in vivo brain. It improves image quality while having minimal effects on electrophysiological properties of neuro...

SeeDB-Live is a tissue-clearing approach for live tissue slices or brains, improving image quality while having minimal effects on electrophysiological properties of neurons. @imailab.bsky.social

www.nature.com/articles/s41...

#FluorescentFriday recorded by @shreyac.bsky.social and Thomas Bailey🔬🧪 🧠

Don’t deprioritize curiosity-driven research Around the world, governments are demanding that research funding follow broader political priorities. They should be careful what they wish for.

www.nature.com/articles/d41...

Competition-funded PhD studentships are available in our group. If you would like to join us, please get in touch by email to discuss potential projects.
phd.leeds.ac.uk/funding/209-...

It was a pleasure to give the Adrian Seminar in this historic building

Fantastic visit to the Centre for Developmental Neurobiology at Kings College. Impressive science underway.

British Neuroscience Association’s response to the Government strategy on animal testing and new alternative methods

www.bna.org.uk/resource/bna...

Integration of hunger and hormonal state gates infant-directed aggression - Nature Combined behavioural, circuit-level and cellular approaches are used to demonstrate how hypothalamic neurons integrate hunger and oestrous state to drive a switch in how female mice interact with pups...

Out today in Nature: We uncover a neural mechanism for the integration of two internal states - hunger and estrous state - and how this integration shapes pup-directed behaviors in mice.
www.nature.com/articles/s41...

High-resolution #CryoET provides ‘compelling’ evidence for the true 3D architecture of glutamatergic synapses: a complex ‘synaptoplasm’ rather than the textbook postsynaptic density.
buff.ly/hOYKjHH

Shreya @shreyac.bsky.social gave an excellent talk at this week's UKSN conference in beautiful Cambridge.

bsky.app/profile/elis...

@shreyac.bsky.social

Olfaction geeks, come to Cambridge next month for a 30yrs old cross-disciplinary smell chat from philosophy to clinics to circuits 🧠👃
Headliner @dattalab.bsky.social on his lab's brand new olfactory maps study
Networking lunches, fancy College dinner, student discount, plenty of coffee. Go register!

🚨 Preprint alert! 🚨
Can mice estimate the distance to an odour source?
New work led by Cristina Marin and colleagues, jointly supervised by @andreas-t-schaefer.bsky.social at the @crick.ac.uk and myself.

Spoiler alert: Yes, they can!

Read the paper here: bit.ly/43A9tF9
Short 🧵 below

Bottom of Malham cove

On the way to Gordale Scar

Steps to the top

Top of the cove

Johnston and Filippi lab walk in the Yorkshire Dales

Amplification of Olfactory Transduction Currents Implements Sparse Stimulus Encoding Sensory systems must perform the dual and opposing tasks of being sensitive to weak stimuli while also maintaining information content in dense and variable sensory landscapes. This occurs in the olfa...

Now in its final form, our recent work on how olfactory transduction currents help ensure sparse sensory coding. Led by a post-bac Kai Clane Belonio and a graduate student, Eyerusalem Haile, this was a group effort by the entire laboratory.

www.jneurosci.org/content/45/1...

Beautiful and fascinating work!

Recalibrating Olfactory Neuroscience to the Range of Naturally Occurring Odor Concentrations Sensory systems enable organisms to detect and respond to environmental signals relevant for their survival and reproduction. A crucial aspect of any sensory signal is its intensity; understanding how...

Check out our review comparing typical experimental to naturally-occurring odor concentrations. You might be surprised.
www.jneurosci.org/content/45/1...
Thanks to Matt and Betty for asking me to take part!

A new collaborative effort on the impacts of mutations in PDZD8: Autistic features in humans, with mice displaying impaired social recognition behaviour, social odour recognition, and metabolic changes. Well done Dr Pantiru! 🧠 🧪 rdcu.be/ebCH8

Axially decoupled photo-stimulation and two photon readout (ADePT) for mapping functional connectivity of neural circuits All optical physiology in vivo provides a conduit for investigating the function of neural circuits in 3-D. Here, we report a new strategy for flexible, axially-decoupled photo-stimulation and two pho...

New preprint: a simple method (ADePT) for optical control and recording of activity by axially-decoupling the focal planes for widefield patterned photo-stimulation and two photon imaging. Proof-of-principle analysis of functional connectivity in the olfactory bulb. 1/7 #neuroscience

A hypothalamic circuit underlying the dynamic control of social homeostasis Nature - New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social...

Our latest findings on social behavior circuits is out: how does the brain responds to social isolation? Terrific work by @dingliu.bsky.social et al. uncovering a circuit with similar neural architecture as physiological needs (hunger, thirst, sleep..). Detailed thread soon.
rdcu.be/ebo63

Get Data - A "Get Lucky" Science Parody YouTube video by Neuro Transmissions

m.youtube.com/watch?v=oJN6...

The Effect of Olfactory Disorder (and Other Chemosensory Disorders) on Perception, Acceptance, and Consumption of Food People with changes in the overall sensory experience of food often complain of taste disturbances, although the problem is normally caused by the loss of aroma in the food (thus an olfactory disorder...

Alexander Fjaeldstad and I have a new chapter in the book Smell, Taste, Eat: The Role of the Chemical Senses in Eating Behaviour, edited by @LorenzoDStafford. Lots of great insights here.

From our chapter, it’s clear that smell loss and its impact on ingestion remain vastly underexplored."

Leeds becomes first Russell Group university to quit X - Research Professional News Leeds says Elon Musk’s social media site “no longer aligns with our university values”

Leeds becomes first Russell Group university to quit X but will stay on other platforms like Bluesky. www.researchprofessionalnews.com/rr-news-uk-u...

Retinal ganglion cell filled with a fluorescent dye

A nice (dendritic) tree for the #FluorescentFriday before Christmas. 🎄

Reconstructed and modeled in elifesciences.org/articles/06250

Single-neuron representations of odours in the human brain - Nature Human piriform and mediotemporal neurons encode odours, and signal how we perceive, rate and identify scents.

🔊Major Breakthrough

Researchers from @UniklinikBonn @unibonn.bsky.social @rwth.bsky.social reveal how single neurons respond to smells, images & words!

This study in @natureportfolio.bsky.social bridges the gap between animal & human olfactory research!👃

📖 www.nature.com/articles/s41...

Perceptual constancy for an odor is acquired through changes in primary sensory neurons Learning-induced changes in primary sensory neurons support concentration-invariant perception of an odor.

We have a fresh new paper!
The PhD project of the talented Mark Conway.

A learning-induced change in the sensitivity of olfactory receptor neurons enables consistent perception of an odor. #olfaction #neuroscience

www.science.org/doi/10.1126/...