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Posts by Nathan Roach

Job Summary: The FlyBase project is an international collaboration of ~35 people distributed at several sites. This position is located at Harvard University, Cambridge, MA. All FlyBase staff work as a part of a team, in which curators and software engineers collaborate extensively. Each site has its own set of responsibilities. The Harvard FlyBase curators focus on curation/annotation of literature and high-throughput data pertaining to the Drosophila genome, transcriptome and proteome. FlyBase is constantly evolving, seeking both to improve and to expand its role within the Drosophila and wider scientific communities. The ideal applicant will be enthusiastic about participating in this process, bringing to the FlyBase group expertise and ideas concerning emerging directions in Drosophila biology and genomic/proteomic analysis. FlyBase is increasingly integrating artificial intelligence and machine learning tools into its curation workflows. The ideal candidate will be open-minded and enthusiastic about exploring AI-assisted approaches to biological data curation, including the use of large language models and AI coding assistants to accelerate and enhance curation tasks.

Job Summary: The FlyBase project is an international collaboration of ~35 people distributed at several sites. This position is located at Harvard University, Cambridge, MA. All FlyBase staff work as a part of a team, in which curators and software engineers collaborate extensively. Each site has its own set of responsibilities. The Harvard FlyBase curators focus on curation/annotation of literature and high-throughput data pertaining to the Drosophila genome, transcriptome and proteome. FlyBase is constantly evolving, seeking both to improve and to expand its role within the Drosophila and wider scientific communities. The ideal applicant will be enthusiastic about participating in this process, bringing to the FlyBase group expertise and ideas concerning emerging directions in Drosophila biology and genomic/proteomic analysis. FlyBase is increasingly integrating artificial intelligence and machine learning tools into its curation workflows. The ideal candidate will be open-minded and enthusiastic about exploring AI-assisted approaches to biological data curation, including the use of large language models and AI coding assistants to accelerate and enhance curation tasks.


Job-Specific Responsibilities: 
	•	Reading and abstracting of data from the current Drosophila literature, including its relationship to human disease, physical interactions, and gene expression 
	•	Evaluating and validating AI generated annotations and curation suggestions, ensuring accuracy and biological relevance before integration into the database 
	•	Using AI coding assistants (e.g. Claude Code, Codex, Gemini) to write scripts for data wrangling, format conversion, and routing curation tasks 
	•	Providing feedback on AI model outputs and refining prompts to help improve automated curation pipelines and annotation quality over time
	•	Annotation and analysis of the Drosophila melanogaster genome, including gene models, mapped mutations, and regulatory features
	•	Together with curators and developers at other sites, interact with broad research community by answering helpmail and giving presentations and tutorials at research conferences 
	•	Handling high-throughput datasets and associated metadata

Job-Specific Responsibilities: • Reading and abstracting of data from the current Drosophila literature, including its relationship to human disease, physical interactions, and gene expression • Evaluating and validating AI generated annotations and curation suggestions, ensuring accuracy and biological relevance before integration into the database • Using AI coding assistants (e.g. Claude Code, Codex, Gemini) to write scripts for data wrangling, format conversion, and routing curation tasks • Providing feedback on AI model outputs and refining prompts to help improve automated curation pipelines and annotation quality over time • Annotation and analysis of the Drosophila melanogaster genome, including gene models, mapped mutations, and regulatory features • Together with curators and developers at other sites, interact with broad research community by answering helpmail and giving presentations and tutorials at research conferences • Handling high-throughput datasets and associated metadata

FlyBase is seeking a new scientific curator at our Harvard University site.
More information here: wiki.flybase.org/wiki/FlyBase...

1 week ago 9 15 1 1
Humane Genetics Curriculum | Libraries Publishing Division | Purdue University

I hope this isn’t the end of Brian’s career but if there’s something people can do, it’s use his material in your classes (thankfully carried on by @robbeewedow.bsky.social and company)

2 weeks ago 24 12 0 1

Someone with the handle @velocity69.bsky.social is sharing a video with the caption:

"The highest quality video of the moon was just released…
so beautiful

* Artemis II"

It's gone viral, but it's not from Artemis II. If you've shared it, you might want to un-share.

2 weeks ago 4604 2074 145 255
Intramolecular interactions between folded and disordered regions shape ubiquilin structure and function Multidomain proteins consist of folded domains connected by intrinsically disordered regions. The flexibility afforded by the disordered regions coupled to the structure and surface chemistry of folded regions allows for unique structural and functional features in these proteins. Yet how intramolecular interactions between disordered regions and folded domains affect multidomain protein structure and function remain poorly understood. Here we use a range of biophysical and computational approaches to measure the intramolecular interactions between the folded domains and disordered regions of ubiquilins (UBQLNs) - essential components of protein quality control that shuttle poly-ubiquitinated client proteins to proteasomal degradation or autophagy. Starting with the yeast UBQLN homolog Dsk2, we find that interactions between two folded domains located at the opposite ends of UBQLN bring about a closed conformation. The prevalence of this closed conformation, however, is modulated by intramolecular interactions involving the disordered regions and folded STI1 domain at the center of the protein. Simulations and analysis of UBQLN homologs across multiple eukaryotic lineages reveals that these disordered:folded domain interactions exist in some UBQLN homologs but are absent in others, indicating possible fundamental differences in function among proteins with the same multidomain architecture. ### Competing Interest Statement The authors have declared no competing interest.

Ever wonder how IDRs and folded domains work together to control function? Using ubiquilins, multidomain proteins involved in protein degradation, we show in our new preprint that IDRs aren’t just linkers, but regulate ensemble and function. Read it here: doi.org/10.64898/202...

1 month ago 20 11 1 2
Bob Dylan - The Times They Are A-Changin' (Official Audio)
Bob Dylan - The Times They Are A-Changin' (Official Audio) YouTube video by BobDylanVEVO

Reviewed my first PR in which the default random seed was set to 67.

youtu.be/90WD_ats6eE?...

1 month ago 1 0 1 0

if you do not want to watch the video, go to settings > content and media and uncheck the "autoplay videos and gifs" box right now

3 months ago 822 428 12 45
3 months ago 2614 562 13 2
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From the people who brought you the angry man “Angron” and the leader of the Iron Hands being named Ferrus Mannus.

4 months ago 14 0 0 0
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🧬Explore the latest from Bioinformatics Advances: “Ish: SIMD and GPU accelerated local and semi-global alignment as a CLI filtering tool.”  

Read the full paper here: https://doi.org/10.1093/bioadv/vbaf292

Author: @ducktapeprogrammer.bsky.social

4 months ago 9 6 1 1

Apparently there’s a never ending stream of folks who think the issue with phrenology was the accuracy of the calipers.

5 months ago 5 0 0 0

Hire Nur!!

6 months ago 8 2 1 0
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sigh

7 months ago 30 8 1 3

I really hate the term "sideloading". I preferred the original term, which was "installing software on a computer that you own"

7 months ago 8453 3688 56 36

God I wish that were me.

8 months ago 4 0 1 0
The view from a sand dune in great sand dunes national park. A long sand stretch in the foreground, and a mountain and the sky in the background.

The view from a sand dune in great sand dunes national park. A long sand stretch in the foreground, and a mountain and the sky in the background.

A selfie with two people in front, and a stone palace behind, the cliff palace at Mesa verde National park.

A selfie with two people in front, and a stone palace behind, the cliff palace at Mesa verde National park.

A sunrise over the desert of canyonlands national park. A mesa is in the middle of the rising sun.

A sunrise over the desert of canyonlands national park. A mesa is in the middle of the rising sun.

The view from the top of a rock in canyonlands national park. Rocks and mesas dotted with sparse foliage.

The view from the top of a rock in canyonlands national park. Rocks and mesas dotted with sparse foliage.

Been doing some traveling

8 months ago 2 0 1 0

The Meselson and Stahl experiment demonstrated in 1958 that DNA replicated semi-conservatively.

Meaning, each of the two strands of DNA serves as a template for a new copy to made of the complementary strand.

Foundational finding, elegant experimental design.

9 months ago 211 64 11 4
9 months ago 4 1 0 0
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FWIW, I really appreciate that you have dedicated time to it. Your papers addressing it is important work, even if it shouldn’t have to be.

9 months ago 26 0 1 0

Soy facing at the concentration camp sign in my officially licensed concentration camp merch

9 months ago 0 0 0 0

Fascism looks a bit different in every country because it is a push towards return to an imagined past (and the past being imagined is different in different places), but the conspicuous consumption culture of the US and past of race segregation results in the most despicable people on earth.

9 months ago 1 0 1 0

This chart has been widely shared on here, it’s important to see the correction

9 months ago 2216 553 23 6

centrists constantly complain about the left being insufficiently partisan and then line up behind a Democrat who handed the state Senate to Republicans and then gerrymandered the state to their benefit

9 months ago 1406 214 11 10

This is a vital message: one of the larger reasons BlueSky is refreshingly free of alt-right shitlords is because in the early days we made a gentleperson’s agreement to starve these fuckos out and it worked. No likes, no quotes, no engagement. They got bored and left. Please keep the Old Ways.

10 months ago 31569 13906 857 546

Thanks to @michaelhobbes.bsky.social and Peter Shamshiri for this public service. This book has been widely celebrated by “very serious people“. The problem is that it is scientifically illiterate, and a clear case of motivated reasoning.

10 months ago 497 119 7 0
10 months ago 1 0 0 0

I'm trying to comment on this without being hyperbolic.

As a manager, insisting on deadlines that you and your ICs straight up don't believe are possible almost GUARANTEES that a) their work will be thrown out or completely redone and b) you will put them in danger of burning out.

10 months ago 2297 484 20 15

ish is a grep-like CLI tool that uses optimal alignment instead of exact matching.

It’s record-type aware, supporting line, FASTA, and FASTQ records.

Built in Mojo as a proof of concept for bioinformatics.

🧵1/5

10 months ago 45 24 1 2
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Abolishing ICE is now the compromise position. These evil dickheads need to be sent to The Hague

10 months ago 19 3 0 0

Are you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)

10 months ago 70 98 2 4
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They're literally doing the meme

10 months ago 15038 3220 139 112