Excitingly, we find that the SND3 translocon has an analogous organisation to the metazoan multipass translocon, indicating that fungi and other eukaryotic taxa have evolved a distinct, reduced-complexity machinery for the insertion of multipass membrane proteins.

Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...

First attending to international conference🌎 — GRC Membrane Protein Folding in Barcelona —truly inspiring🥳

❤️Proud to share my PI, @melaniemcdowell.bsky.social 's talk on Fungal ER Membrane Protein Biogenesis, led by @tzujingyang.bsky.social

#GRC2025 #MembraneProtein #StructuralBiology #SNDpathway