Worldwide flu outbreak killed 45,000 American Soldiers during World War I In September 1918 there were two killers in the world. World War I, which would claim 20 million lives by its end, and the flu pandemic known as the Spanish Flu, is estimated to have killed between at...

~53,000 military personnel died in combat in WW1. ~45,000 other soldiers died from the flu. #PeteHegseth may be ignorant of history, careless about the lives of those in uniform, but the army remembers. www.army.mil/article/2104...

Evidence Over Eminence: Rethinking Specialty Guidelines Amid the ATS-IDSA Debate Brad Spellberg, MD, Bassam Ghanem, PharmD MS BCIDP, Miguel Morante-Ruiz, MD, Émilie Bortolussi-Courval, RN PhD, Anil N Makam, MD MAS, Zeynep Ergenc, MD, Ni

Proud to be part of this great team led by @bradspellberg.bsky.social
🔥Our LTE is now published
“Evidence Over Eminence: Rethinking Specialty Guidelines Amid the ATS–IDSA Debate.”
A timely discussion on evidence vs eminence in the guidelines development. #IDsky
academic.oup.com/cid/article/...

Low yield of blood cultures after end-of-therapy of an episode of infective endocarditis: a twelve years’ experience from a referral centre. AbstractIntroduction. Infective endocarditis (IE) carries a significant risk of recurrence. European clinical guidelines recommend performing follow-up blo

Low yield of blood cultures after end-of-therapy of an episode of infective endocarditis: a twelve years’ experience from a referral centre.

✅ Just Accepted
🔗 bit.ly/4cnJJQT

Adjunctive corticosteroids may have a role in M. pneumoniae CAP 🫁- In a multicentre RCT among 70 hospitalised adults, oral betamethasone significantly shortened time to resolution of hypoxaemia vs standard care. Presented at #ESCMIDGlobal2026
👇
www.thelancet.com/journals/lan...

🔥 Late Breakers
SNAP platform RCT| Adjunctive Clindamycin in S.aureus bacteraemia
❌ No mortality benefit
90d mortality:16.9% vs 15.2% aOR 1.16 (CrI cross 1)
📊PPSup(~7%)→Futility threshold reached
⚠️ICU subgp:numerically worse with clinda
⚖️CDAD:no # (~2%)😯
#ESCMIDGlobal2026 #idsky

🔥 💥Late-Breakers |COBRA RCT
1-day of antibiotic treatment after adequate endoscopic biliary drainage is non-inferior to 4-7 days in adults with acute cholangitis.
💡 Shorter is better+source control
Practice-changing? #ESCMIDGlobal2026 #idsky

#IDSky

▶️💥When the fairy dust settles: critical appraisal of presented trials
Excellent talk by Prof.HUTTNER @angelahuttner.bsky.social
How did PeterPen replicate the MERINO trial?
Co-intervention bias?
Are you going forward to 1000 patients for 30d mortality?
Did you get FUBC?
🌟7d? #ESCMIDGlobal2026

Understand the frustration that Bluesky hasn't taken off more for science discourse, but going back to X is *not* the answer. X is a sewer that exists to platform white supremacist and anti-science nonsense. Maybe more community-building events here? Is ID Journal Club a thing? #IDSky

🔥Late Breakers
PeterPen RCT prelim results challenges carbapenem default in ESBL BSI
Pip/tazo vs MER (EI)
✅Non-inferior 7d failure(29.4% vs 33.5%)
❌No early mortality signal
30d mortality 14.4%(interim)
👉Will mortality follow?MERINO taught us the hard way!
#ESCMIDGlobal2026 #IDsky

Scary MDR TB results from South Africa

Rifampicin-R NOT detected by Xpert assay

#IDSky

Research in context panel for a paper published in The Lancet, entitled "Clinical and bacteriological effectiveness of three different short-course antibiotic regimens and single-dose fosfomycin for uncomplicated lower urinary tract infections in women (SCOUT): a pragmatic, multicentre, open-label, randomised clinical trial". Copyright: 2026 Elsevier Ltd. All rights reserved.

A new study, presented at @escmid.bsky.social, found that Nitrofurantoin was the most effective treatment and single-dose fosfomycin the least effective treatment for uncomplicated urinary tract infections.

Explore the research 👉 spkl.io/63320A4Yui #ESCMIDGlobal2026 #ESCMID

Single-dose fosfomycin likely not sufficient for many cases of cystitis

#IDSky

Is there a future in which daptomycin replaces vancomycin for empiric meningitis coverage for resistant Strep pneumo?
#IDSky

Whistleblower says Trump officials thought USAID did 'just abortions,' asked for 'Barney-style' slides before gutting agency, per new book Read an exclusive excerpt from Nicholas Enrich's "Into the Wood Chipper"

NEW—I got an exclusive excerpt from a USAID whistleblower's new book that made me gasp multiple times. It details Trump's dismantling of the humanitarian aid agency & his team/DOGE's shocking ignorance to public health.

'Into the Wood Chipper' by Nicholas Enrich is out tomorrow. Read excerpt here:

‘Everyone is Replaceable’: Death Rattles Oregon Amazon Facility A worker died at Amazon’s Troutdale warehouse last week. Employees were told to look away.

A worker died at an Amazon warehouse in Oregon last week.

For more than an hour, workers were instructed to continue working as the man lay dead.

One worker wanted to help, but a manager told them to “Just turn around and not look. Let’s get back to work," according to @thewesternedge.bsky.social.

Major news in the #Candida world! C. glabarata is now the most common cause of candidemia in US hospitals. Collaboration between CDC, UTHealth and Harvard investigators #IDSky #MedSky @msgerc.bsky.social

Line graph showing the percentage distribution of Candida species from 2016 to 2024. Candida albicans is the most common species in most years, declining from about 36% to 32%. Candida glabrata increases overall, rising from about 25% in 2016 to a peak around 34% in 2024. Candida parapsilosis fluctuates between roughly 8% and 17% before declining to about 8% by 2024. Candida tropicalis and unspecified/other species remain relatively stable at lower levels (about 6–12%). Multiple-species infections decrease slightly over time. Candida auris is absent before 2022 and then increases to about 5% by 2023–2024.

Candida glabrata emerges as the most common cause of candidemia: analysis of a large hospital-based database, United States, 2016–2024

academic.oup.com/cid/advance-...

Jeremy Gold & colleagues at CDC Mycotic Diseases Branch, @jessicalittlemd.bsky.social and @drluiso.bsky.social

One of the ways news media often fail us is by giving us the microscopic rather than the telescopic view. Everything I mention in this essay is well-documented, but the dots are mostly not connected to make visible this death by a thousand cuts our country is undergoing.

An mRNA treatment for PANCREATIC CANCER was in trials, among many other uses. Choosing to end this research is choosing to sentence millions to an early, painful death

Population discontinuity in the Paris Basin linked to evidence of the Neolithic decline - Nature Ecology & Evolution Analysis of ancient human genomes from a Neolithic collective gallery grave in northern France points to population discontinuity and turnover between the third and fourth millennium BC.

More evidence that the Neolithic population collapse in Europe may have been related to zoonoses brought by migrating Indo-Europeans. A Neothilic mass burial from 3000 BCE shows traces of bubonic plague, yersiniosis, and louse-borne relapsing fever #IDSky

Too young for the MMR shot, babies become 'sitting ducks' in measles outbreaks Babies too young to be vaccinated are among the most vulnerable in measles outbreaks like the one in South Carolina, which is the largest the U.S. has seen in decades.

Too young for the MMR shot, babies become ‘sitting ducks’ in measles outbreaks

Age-Specific Risk of Herpes Zoster in Adults Aged ≥18 Years With Comorbid Conditions—A Retrospective Cohort Study in the United States A retrospective US study in immunocompetent adults found that adults aged ≥30 years with asthma, chronic obstructive pulmonary disease, depression, diabete

Interesting look at the risk of zoster infection in younger populations with comorbidities…

Also, I’d like to meet the 50-59 year comparators who had no stress 😎

academic.oup.com/cid/advance-... #IDSky

Rep. Alexandria Ocasio-Cortez, D-N.Y., attends a news conference in the U.S. Capitol. (Tom Williams/CQ-Roll Call, Inc via Getty Images)

AOC: “This is a threat of genocide & merits removal from office. The President’s mental faculties are collapsing & cannot be trusted.

To every individual in the President’s chain of command: You have a duty to refuse illegal orders. That includes carrying out this threat”

You have more in common with the people of Iran than you do with anyone in this administration, any member of the technocracy, anyone who is profiting from this war, or any billionaire. When you see Iranians forming human chains outside key infrastructure sites, you should feel a sense of kinship.

After taking time to connect with the Pretti family and with their consent, we are honored to share that we have created the Alex Pretti Nursing Scholarship.

For those interested, you can learn more and make a gift here: crowdfund.umn.edu/campaigns/Al...

Trump administration orders dismantling of the U.S. Forest Service Late Tuesday afternoon, with the subtlety of a wrecking ball and the morality of a foreclosure notice, the Trump administration announced the most devastating attack on the U.S. Forest Service in the ...

Amidst everything else, the Trump regime has quietly killed off the U.S. Forest Service 🌲

“One hundred and ninety-three million acres of your national forests… just handed, on a silver platter, to the people who’ve spent their entire careers trying to destroy it.”

www.hatchmag.com/articles/tru...

Death of a refugee left at a Buffalo doughnut shop by Border Patrol is ruled a homicide The Erie County Medical Examiner's Office didn't reach any conclusions about responsibility for Nurul Amin Shah Alam's death.

The death of a nearly blind refugee from Myanmar who was found on a Buffalo street in February — five days after Border Patrol agents left him at a doughnut shop — has been ruled a homicide, authorities said Wednesday. https://to.pbs.org/3NZGHsz