Has the word Nature in the title.

So disappointing to read the emails about pushing admissions for wealthy kids and the Epstein jokes.

The newly reviewed ones that score in the middle third are ND with a specific designation. In theory when Councils meet in February they can be selected for funding.

Too bad my institution doesn’t have Google account but for personal use Gemini keeps being g the way to go for simple and not so simple tasks.

Sacituzumab Tirumotecan in EGFR-TKI–Resistant, EGFR-Mutated Advanced NSCLC | NEJM Sacituzumab tirumotecan (sac-TMT) is an antibody–drug conjugate targeting trophoblast cell-surface antigen 2 that has shown significant survival benefits in patients with EGFR-mutated non–small-cel...

Launched free version of Gemini on Chrome browser. Same query as co-pilot. Immediate single answer - www.nejm.org/doi/full/10.... with a nice summary! Life in 2026!

Onto Copilot - asked Can you find a recent New England Journal of Medicine paper from Chinese investigators on a new treatment for lung cancer that failed EGFR inhibitors? No luck, found other article and kept asking for clarification but crashed. 3/3. Finally

Searching for article part 2. (2) Next pubmed searched a million ways lots of articles not the one, another late study published in 2024 kept coming up. Next onto AI. Have an account w/ copilot. 2/2

I was trying to find an article for a family member with lung cancer that I knew I read in last few months in New England Journal on a clinical trial. (1) First went to NEJM website since I subscribe - no luck searching on lung cancer, failed EGFR, Chinese (site of study), 1/4

His teammates saved him. If they would have lost, his time with the Seattle fans would have been unbearable (from someone who lived in Boston during the 1986 Bill Buckner error.

Can’t figure out how they can’t develop a program that doesn’t fabricate references.

Can anyone figure out this spam. A real person called my husband’s cell twice saying he was getting calls from him. The person read out my husband’s cell even though he never called him. That happens. The strange part is that when the person called my husband it showed MY cell phone number twice!!

Thanks for writing the back story of this company. Unfortunately, one of several now.

Is there a good example of an analysis that still routinely relies on them?

The retraction statement is much more detailed in identifying all of the problems with the paper.

We demonstrated that testing was feasible and about 25% of recurrent tumors had variants in cancer predisposition genes of which 20% were germline. Rapid reflex germline testing of tumor results is warranted.

Germline Cancer Predisposition Results From the National Cancer Institute-Children's Oncology Group Pediatric MATCH Trial - PubMed Coordinated germline and tumor panel testing was feasible and revealed P/LP CPG variants in 6.3% of the Pediatric MATCH cohort. Tumor variant fraction, germline association of CPG with tumor type, and adult-oriented guidelines were not predictive of germline status, emphasizing the need for systemat …

Happy to report that the results of germline testing as part of the National Cancer Institute/Children’s Oncology Group MATCH precision oncology trial was published. pubmed.ncbi.nlm.nih.gov/41166674/

Appreciate it.

I’m scheduled for a late November study section but they haven’t given us our review assignments. Anyone know the minimum time to review is required.

Totally agree on how hard it is to get reviewers for many journals.

Welcome to #ASHG25! As our President Sarah Tishkoff just noted, next year for the first time the ASHG exec cmte will be all women. Glad to have anyone and everyone participating in this society now and in the future.

First Plenary Abstract Session of #ASHG25 starting with Srikar Gopinath from Yale describing their study characterizing >1M variants in the 5' UTR regions to assess their functional effects on gene translation and develop a prediction algorithm to evaluate non-coding UTR variation.

Congratulations to Andy Rivera @poseypod.bsky.social lab @bcmhouston.bsky.social grad student for putting together a standing room only session at #ASHG25

Arrived at 11:00pm

Will you be at the Baylor party?

Nicky - on an 8 hour delayed flight but happy to talk at ASHG about new guidelines.

Interested in this point. If it does a task the suggested prompts are often - make it better or change tone. That suggests to the user that it can evaluate its own response. Is that not true?

I’m a child of a German Jewish family that escaped in 1939 - growing up in Philadelphia I remember reading many times over a book about how Denmark saved their Jewish population in boats to Sweden. It was very important to have that one story of a country which didn’t allow the massacre to occur.

Is there a way to download this thread (like in Twitter) as I would love to she with some AI believer colleagues.

Excited to have an entire session on different aspects of germline and somatic cancer curation in ClinGen - clinicalgenome.org today at the Cancer Genomics Consortium annual meeting in Houston. #CGCAnnual2025

Agree - I was thinking that is a lot of walking