There needs to be a giant billboard in every major American city that touts this. In any other era except this suicidal science administration, this would be a miraculous, wondrous thing.

Want to work in one of the most dynamic places in mathematical biology - in one of the oldest universities in the world - great colleagues, great science.

🚨With some delay, we're excited to announce that our proposal for a MSCA Doctoral Network on Evolutionary Medical Genomics (EvoMG-DN) got funded! 🎉

🧬 14 labs and 2 companies across 7 European countries will be coordinated by the EvoMG Joint Program at @crg.eu & @upf.edu.

europa.eu/!NNq63m

🗞️Our March issue is live, with killifish artwork by
Dario Valenzano on the cover!🎨Read work on senescence in mammary gland remodelling, structural protein changes as readouts of Alzheimer’s disease, the 201 Parkinson’s disease trial & more ✨https://nature.com/nataging/volumes/6/issues/3

We are suckers for hand-drawn fish 😍 @dvalenzano.bsky.social 👏

🤩

I think this is our lab's first paper in a proper ecology journal. We are now card carrying ecologists!

GitHub - valenzano-lab/aegis: Numerical model for life history evolution of age-structured populations Numerical model for life history evolution of age-structured populations - valenzano-lab/aegis

Try AEGIS, break it, extend it, and tell us what questions you want it to answer next. Code is on GitHub: github.com/valenzano-la....
The best tool is one the community makes its own.

This paper is the product of years of work by generations of lab members. Huge congratulations to Martin Bagič (lead), and to Arian Šajina and Will Bradshaw who built the foundations. AEGIS grew out of their collective effort and creativity.

AEGIS runs via a GUI, a webserver, or command line. You don't need to write code to ask deep evolutionary questions. It's built for students and researchers alike. Flexible, extensible, and fully documented.

Unlike analytical models, AEGIS is bottom-up. Aging, mortality plateaus, lifespan variation — these emerge from individual genomes interacting with the environment. Population-level patterns are outputs, not inputs. That's the point.

As a proof of concept, AEGIS replicates Michael Rose's classic Drosophila experiment: select for delayed reproduction, and delayed aging evolves. AEGIS reproduces this result in silico — and lets you extend it to ask questions the lab experiment hardly could.

AEGIS models how extrinsic mortality, ecological pressures, population size, mutation rate, recombination rate, and reproductive strategy together shape the evolution of lifespan and aging. Fast vs. slow senescence emerges from the simulation — it is not assumed.

AEGIS: Individual-based modeling of life history evolution Author summary Life history traits - such as lifespan, age at reproduction, and fertility - vary widely across species and environments and are shaped by evolutionary processes acting over long timesc...

🧵 Thrilled to share that AEGIS (Ageing of Evolving Genomes In Silico) is now published!
AEGIS lets you run your evolution experiment in silico. Want to know how predation, population bottlenecks, or mutation rate shape lifespan? Run the experiment. No organisms required.
📄 doi.org/10.1371/jour...

Did you know that Evolution Letters now publishes reviews?! Our inaugural one is fantastic! Deep learning is opening new doors for evolutionary genomics, especially for nonmodel organisms with sparse or uncertain genomic data. doi.org/10.1093/evle...

Thanks Leo - I hope you're well.

Thanks Mo! How are you doing? Hope all's well.

Spontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish - Nature Aging Turquoise killifish are naturally short-lived vertebrates that serve as a model system for aging. The authors show that killifish exhibit age-related transformation in the immune system, which rapidly...

Aging killifish show systemic inflammation and accumulating DNA damage in progenitor-like immune cells, offering a window into the evolutionarily conserved mechanisms of vertebrate immune aging.
Great work from Gabriele, @mdonertas.bsky.social, and the whole team.
www.nature.com/articles/s43...

Daily movement and sleep patterns can predict lifespan with striking accuracy Some fish, it turns out, are morning people. They swim hard during daylight, sleep mostly at night, and tend to live longer.

Now at Princeton, @clairebedbrook.bsky.social and @ravi-nath.bsky.social led a study during their time as postdocs at Stanford that mapped the full arc of aging in individual vertebrates for the first time, finding that activity levels in young adults may serve as an early predictor of longevity.

Litonotus is such a sophisticated hunter. It chases Euplotes and evaluates when to shoot its deadly dart. Euplotes, on the other hand, deploys unpredictable moves to elude the chase. Their strategies improve with experience. Whether associative or not, that looks like learning to me.

My vote goes for Litonotus lamella and Euplotes crassus.

🚨🧬🚨

We're looking for a specialized Research Assistant to spearhead a project aimed at exploring new RNA therapeutics in diabetes and other metabolic disorders.

Junior or Senior, we're hoping to recruit a highly motivated and self-driven scientist interested in both basic and applied science. 🦄

Do you want to know more about how #killifish research can advance our understanding of retinal diseases? Have a look at Sofia Manzo's exciting work! Sofia is PhD fellow of the MSCA-DN @progret2024.bsky.social
@cabd-upo-csic.bsky.social @jrmarmor.bsky.social
#killifish #retinaldisease #aging
🧬👌🧬

The VEO Group at @uni-jena.de @microverse.bsky.social has an open position for a Bioinformatics Technician until the end of 2032! Join us to unlock the secrets of the Microverse from big datasets: jobs.uni-jena.de/jobposting/0...

Happy to share my solo-authored Perspective "An Interpretation, Survey, and Outlook of Microbial Macroecology"! Making time these last few months to take stock of the patterns us microbial ecologists examine + models we invoke has been invaluable. Feedback welcome!

ecoevorxiv.org/repository/v...

We have an open position for a bioinformatics/theoretical microbial ecology PhD student to study viral strategies in the global Microverse! Join us at the @microverse.bsky.social at @uni-jena.de, please apply through this link:
jobs.uni-jena.de/jobposting/9...

For those interested!

My dept has an open assistant professor position (DL 2nd Feb). Although the call indicates special interest in datacenter-scale computing systems research, any research area is applicable and this would be a great place also for someone doing Bayesian flavored research

www.aalto.fi/en/open-posi...

Jobs - Balance of the Microverse

Decode microbial balance with us! 🦠
Our new PhD & Postdoc positions explore: 📡 SIGNALS (Communication) 🏗️ STRUCTURES (Community assembly) 🔄 TRANSITIONS (Stability & tipping points)

Become part of our interdisciplinary network in Jena.

⏳ Deadline: Jan 20, 2026

Hugely proud of superstar postdoc Dennis de Bakker who was awarded the LIFE talent award 2025 at the FSU Jena.