📢 New preprint from the lab🧠
▶️doi.org/10.64898/2026.03.12.710517

What does fMRI connectivity actually reflect at the neural level?
The natural intuition is: more neural activity = more connectivity! Using cortical perturbations we show this is not necessarily the case: sometimes less is more!

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It’s time to rethink Parkinson’s disease. Our work reframes PD as a disorder of the somato-cognitive action network (SCAN), and shows that normalizing SCAN connectivity represents a shared mechanism across diverse effective therapies.
rdcu.be/e2n4t
@ndosenbach.bsky.social @gordonneuro.bsky.social

This is your brain on Ritalin. Got your attention? Stimulant medications like Ritalin (methylphenidate) do, but not in the way you might think. They don't act directly on the brain’s attention systems! Find out what's really happening in @cellpress.bsky.social. doi.org/10.1016/j.ce...

Why doesn't neuroimaging work in psychiatry?

Chronic Pain Is a Brain Network Disorder

jamanetwork.com/journals/jam...

netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1101/2025...

Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging ⤵️

Our paper on the ☀️ "summer slide" 🛝 is out now @pnas.org!
www.pnas.org/doi/10.1073/...
Summer slide is a replicable phenomenon across diverse datasets that's more than "forgetting" school material in vacation months, but effects of socioeconomic inequality are ➡️ 7x bigger! ⬅️
#PsychSciSky #DevPsy
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very impressive work !!!

Patterns of brain-wide associations reflect socioeconomics | bioRxiv www.biorxiv.org/content/10.6...

Prof. Lucina Uddin from UCLA discusses her views on brain networks as studied with functional MRI YouTube video by Neuroscience & Philosophy Salon

𝗕𝗿𝗮𝗶𝗻 𝗻𝗲𝘁𝘄𝗼𝗿𝗸𝘀, 𝘄𝗵𝗮𝘁 𝗮𝗿𝗲 𝘁𝗵𝗲𝘆?
@lucinauddin.bsky.social explains many of the challenges and controversies! Great discussion too.
Check out the latest Neuroscience & Philosophy Salon.
youtu.be/pP5swFPR0Ns

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Brain State Dynamics in Ketamine-Induced Dissociation Resemble Those in PTSD Dissociation, an altered state of consciousness in which individuals feel detached from their body, environment, and sense of self, is a common feature of Post-Traumatic Stress Disorder (PTSD).…

How do dissociative states affect brain state dynamics 🧠, and do these effects vary if pharmacologically induced 💊 or due to a clinical condition 🏥?

Learn more here ⬇️

👏 👏 👏

An Open, Fully-processed, Longitudinal Data Resource to Study Brain Development and Transdiagnostic Executive Function | bioRxiv www.biorxiv.org/content/10.1...

Functional Connectivity Gradients Reveal Altered Hierarchical Cortical Organization in Functional Neurological Disorder Neuroimaging studies of functional neurological disorder (FND), a core neuropsychiatric condition, often rely on discrete connections or parcellations that may obscure the brain’s functional network a...

Westlin and colleagues found that patients with functional neurological disorder exhibit atypical macroscale cortical organization, characterised by altered functional gradients that are linked to symptom severity.

Such a nice collection of brain-body interaction articles in the special issue of @currentbiology.bsky.social. Love the beautiful vagus nerve on the cover by Andreas Vesalius www.cell.com/current-biol...

Excited to share our work making an "allostasis-first" case that brain function is most productively framed in terms of its core regulatory function. We also introduce some new ideas in the context of metabolism and cognitive function in Alzheimer's.
www.cell.com/neuron/fullt...

Stage-Dependent Neural Mechanisms in Human Methamphetamine Abstinence: Insights From the Digital Twin Brain Model Reward circuits are crucial in treating human methamphetamine (MA) addiction, while the underlying mechanisms of action may vary throughout the intervention process. This gap limits the identification...

Zhang et al. leveraged a digital twin brain model with multiscale data to demonstrate that metabolic activities in reward circuits are more prominent during early methamphetamine abstinence, while neuroplasticity is essential throughout both early and later abstinence.

Using Extreme Value Statistics to Reconceptualize Psychopathology as Extreme Deviations From a Normative Reference Model Overview of our approach for extreme value statistics. First, we fit a normative model to imaging phenotypes, before employing a ‘peaks-over-threshold’ approach widely used in meteorology and finance...

A bit belated, but here are some new papers! first, a conceptual framework for modelling extremes in neuroimaging data
onlinelibrary.wiley.com/doi/full/10....

Great work from the inimitable Charlotte Fraza!

Thanks for the figure @bttyeo.bsky.social 🙂🧠🙏🏽!

Turn off Zotero. It's time to play a game.🥰

Excited to share that our work introducing the Reproducible Brain Charts (RBC) data resource is now published in Neuron!! 🎉

📚 Read the paper: authors.elsevier.com/c/1lpaF3BtfH...
🧠 Explore the RBC dataset: reprobrainchart.github.io

Current challenges and future directions for brain age prediction in children and adolescents - Nature Communications This Perspective outlines how brain-age prediction models are increasingly applied to child and adolescent populations and examines the specific challenges this entails. It offers practical recommenda...

www.nature.com/articles/s41...
🧐🧐🧐

Precision Functional Neuroimaging Reveals Individually Specific Auditory Responses in Infants | bioRxiv www.biorxiv.org/content/10.1...

News from ENIGMA-Epilepsy! 🧠

Our latest study links polygenic risk for TLE-HS to cortical thinning in kids—mirroring patterns in adult patients.

Early imaging-genetics insights could reveal interplay of epilepsy risk and phenotypes before symptoms emerge.

Read more 👉 doi.org/10.1093/brai...

Interested in Network hubs, cortical hierarchies, and gradients? Ever wonder where they come from? Check our latest review, where we cover different approaches to mapping hubs, models for their evolution, and mechanisms for how they develop:

osf.io/preprints/os...

Functional connectivity heterogeneity and consequences for clinical and cognitive prediction: Stage 2 registered report Abstract. Functional connectivity is frequently used to assess dynamic brain functioning and predict individual differences in behavioral outcomes, such as psychopathology. Inferences from functional ...

Functional connectivity heterogeneity and consequences for clinical and cognitive prediction: Stage 2 registered report | Imaging Neuroscience | MIT Press direct.mit.edu/imag/article...

I still get chills

Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts

Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE

see videos, read paper, follow thread
doi.org/10.31234/osf...

Polygenic scores for autism are associated with reduced neurite density in adults and children from the general population | Molecular Psychiatry www.nature.com/articles/s41...

🧐four subnetworks within the Action Mode Network related to decisions, action implementation, feedback, and the bodily self