Organ perfusion is entering a promising but complex era. Addressing injury mechanisms like ferroptosis is key to safe, longer preservation.
#transplant #kidney #research #biomedicine

This raises questions about RBC-based strategies. In a joint perspective (Schneeberger et al.) we outline ideas to move forward and avoid these injury pathways.
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However, our group (Marlon de Haan et al.) shows in the same journal that ferroptosis is a key injury mechanism during perfusion—especially when red blood cells (RBCs) are used.
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A recent study in Nature Communications by Richard Dumbill et al. shows normothermic perfusion is feasible for 6+ hours.
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Ex vivo preservation of donor kidneys is crucial to improve transplant outcomes—and may allow future organ repair. But the challenge remains: how to preserve function for longer periods?

Replacing renal function using bioengineered tissues - Nature Reviews Bioengineering Renal function can be replaced by bioengineered kidney tissue. This Review discusses in vivo kidney engineering, xenotransplantation, blastocyst complementation and stem-cell-derived kidney tissue engineering as approaches for renal replacement therapy.

Kidney transplantation is the only definitive treatment for end-stage kidney disease. This article explores challenges in renal replacement and highlights the clinical potential of bioengineering approaches to restore kidney function:

TCA cycle rewiring underpins implantation and histone acetylation programming Metabolism has emerged as a key regulator of stem cell differentiation and their epigenomes. This coupling is particularly evident during the exit from naive pluripotency in vitro. However, our unders...

In a new preprint with @trabelink.bsky.social, T. Moritz & @bonalditiziana.bsky.social, we find that implantation leads to rewiring of the TCA cycle to support histone acetylation turnover and exit from naïve pluripotency. Gr8 work of @elenikafkia.bsky.social D. Pladevall-Morera et al. rb.gy/clk8vm