The impact of a selective androgen receptor modulator (RAD140) on frailty and underlying mechanisms in older male and female C57Bl/6 mice - PubMed Six-weeks of RAD140 treatment did not affect frailty in older male or female mice. The beneficial effects in lean mass, bone mineral density, and systemic inflammation warrant longer treatments to explore any positive impact on frailty in males. RAD140 may not be ideal for achieving these in females …

pubmed.ncbi.nlm.nih.gov/40158703/
We show 6wks of selective androgen receptor modulator (SARM-RAD140) treatment increases lean mass/bone mineral density and reduces inflammation in male, not female mice. Still it did not reduce frailty. Longer term SARMS exposure may be needed to reduce frailty