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Posts by Bill Podlaski

New preprint with @sevberg.bsky.social! We map Hopfield-like binary networks onto spiking networks with dendrites … and it works! Same memory capacity, bigger basins of attraction, plus selective recall through dendritic gating, and more. How? Dendrites! See below.

1 week ago 28 12 1 2

Deadline for the summer school now extended to April 8. Last chance, this time for real :)

2 weeks ago 0 1 0 0
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Applications are open for the Junior Theoretical Neuroscientists Workshop which will take place July 21-24, 2026 at the Center for Computational Neuroscience, @flatironinstitute.org

Travel, lodging, and meals will be covered for accepted participants.
Application deadline: April 15, 2026

3 weeks ago 26 18 1 3
Cosyne 2026 - Cosyne Tutorial: Comparative Analysis of Neural Population Codes
Cosyne 2026 - Cosyne Tutorial: Comparative Analysis of Neural Population Codes YouTube video by Cosyne Talks

Cosyne invited me to give a long tutorial (4 hours!) on methods to quantify differences high-d neural recordings across animals, brain regions, deep neural nets, etc.

The recording is up on youtube. I hope it inspires more research on this fundamental topic!

www.youtube.com/watch?v=n44x...

1 month ago 160 56 3 1
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1/3 New paper accepted at ICRL World Model workshop: Dreamer-CDP: Improving Reconstruction-free World Models for RL. We introduce a Dreamer variant that learns world models without reconstructing pixels. arxiv.org/abs/2603.07083

1 month ago 24 5 2 0
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Inhibitory normalization of error signals improves learning in neural circuits Normalization is a critical operation in neural circuits. In the brain, there is evidence that normalization is implemented via inhibitory interneurons and allows neural populations to adjust to chang...

How do neural circuits in the brain implement normalization? 🧠

In our new paper, we show that just normalizing sensory input isn't enough. Crucially, we must also normalize the error signals! 🧵👇

Paper: arxiv.org/abs/2603.17676

1 month ago 67 21 1 2
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How does an animal choose between exploring for a better food source and taking advantage of a known one? Our recent work in Current Biology demonstrates how recent feeding and metabolic state dynamically influence fly local search. bit.ly/3PfrIv3 #Science #Neurosky #Foraging #Drosophila

1 month ago 133 49 3 4
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22 years of Brain Science: what CoSyNe tells us about the evolution of Neuroscience Tracking the intellectual DNA of Computational and Systems Neuroscience through its flagship meeting

I tracked every keyword in 22 years of Cosyne abstracts to map how computational neuroscience evolved — from Bayesian brains to neural manifolds to LLMs — and where it's heading next.

1 month ago 159 70 7 18

After several years of work, my lab is starting to put out our first papers on learning in a unicellular organism (Stentor coeruleus).

Here we show evidence for a form of associative learning in Stentor:
www.biorxiv.org/content/10.6...

1 month ago 178 58 5 7
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How can we build better experiment-theory collaborations in neuroscience?

We're hosting a series of 6 in-person, interactive workshops to discuss this.

Come along!

www.eventbrite.co.uk/e/understand...

1 month ago 46 14 1 6
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Can we guarantee the behavior of an RNN to generalize well for infinite time? 🧠♾️
Similar to universal approximation theorems in deep nets, for systems that forget everything eventually, there are guarantees. We prove it for multistable systems!
arxiv.org/abs/2602.08640 w/ @memming.bsky.social
(1/6)

2 months ago 6 2 1 2
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Our paper is out in @natneuro.nature.com!

www.nature.com/articles/s41...

We develop a geometric theory of how neural populations support generalization across many tasks.

@zuckermanbrain.bsky.social
@flatironinstitute.org
@kempnerinstitute.bsky.social

1/14

2 months ago 278 101 7 1

neuroAI comparisons of ANNs to brains do have a range of problems. Even more than I had realized. And I was worried before: www.biorxiv.org/content/10.1...

2 months ago 93 28 6 4
Attention-like regulation of theta sweeps in the brain's spatial navigation circuit Spatial attention supports navigation by prioritizing information from selected locations. A candidate neural mechanism is provided by theta-paced sweeps in grid- and place-cell population activity, which sample nearby space in a left-right-alternating pattern coordinated by parasubicular direction signals. During exploration, this alternation promotes uniform spatial coverage, but whether sweeps can be flexibly tuned to locations of particular interest remains unclear. Using large-scale Neuropixels recordings in freely-behaving rats, we show that sweeps and direction signals are rapidly and dynamically modulated: they track moving targets during pursuit, precede orienting responses during immobility, and reverse during backward locomotion — without prior spatial learning. Similar modulation occurs during REM sleep. Canonical head-direction signals remain head-aligned. These findings identify sweeps as a flexible, attention-like mechanism for selectively sampling allocentric cognitive maps. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, Synergy Grant 951319 (EIM) The Research Council of Norway, Centre of Neural Computation 223262 (EIM, MBM), Centre for Algorithms in the Cortex 332640 (EIM, MBM), National Infrastructure grant (NORBRAIN, 295721 and 350201) The Kavli Foundation, https://ror.org/00kztt736 Ministry of Science and Education, Norway (EIM, MBM) Faculty of Medicine and Health Sciences; NTNU, Norway (AZV)

The hippocampal map has its own attentional control signal!
Our new study reveals that theta #sweeps can be instantly biased towards behaviourally relevant locations. See 📹 in post 4/6 and preprint here 👉
www.biorxiv.org/content/10.6...
🧵(1/6)

2 months ago 184 62 4 10
Grumpy from Disney's Snow White and the 7 dwarves.

Grumpy from Disney's Snow White and the 7 dwarves.

Let's talk about "grumpy lab person". Many labs have them. With an eye to keeping science at its most rigorous, they cross the line into criticism that's too harsh. They are the ones who risk killing your scientific spirit. They are reviewer 2. /1

3 months ago 71 19 7 6
Applications for 2026 entry to the Gatsby Bridging Programme (7-week maths summer school) will open on 19 Jan and close on 16 Feb. Designed for students who wish to pursue a postgrad research degree in theoretical neuroscience or foundational machine learning but whose degree programme lacks a strong maths focus. Applications from students in underrepresented groups in STEM strongly encouraged. A small number of bursaries available.
Register for the information webinar on 23 Jan.

Applications for 2026 entry to the Gatsby Bridging Programme (7-week maths summer school) will open on 19 Jan and close on 16 Feb. Designed for students who wish to pursue a postgrad research degree in theoretical neuroscience or foundational machine learning but whose degree programme lacks a strong maths focus. Applications from students in underrepresented groups in STEM strongly encouraged. A small number of bursaries available. Register for the information webinar on 23 Jan.

📢 Applications open on 19 Jan for the 7-week #Mathematics #SummerSchool in London. You will develop the maths skills and intuition necessary to enter the #TheoreticalNeuroscience / #MachineLearning field.

Find out more & register for the information webinar 👉 www.ucl.ac.uk/life-science...

3 months ago 25 27 1 1

We are very excited to announce that our new preprint with Saleh Esteki, @stefanofusi.bsky.social, and @roozbehkiani.bsky.social is now available on biorxiv! www.biorxiv.org/content/10.6.... We investigated how reward context is learned, represented, and updated to bias decisions. Thread 🧵👇! 1/13

3 months ago 25 10 1 1

Please spread the word🔊My lab is looking to hire two international postdocs. If you want to do comp neuro, combine machine learning and awesome math to understand neural circuit activity, then come work with us! Bonn is such a cool place for neuroscience now, you don't want to miss out.

3 months ago 33 37 1 1
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When and why do modular representations emerge in neural networks?

@stefanofusi.bsky.social and I posted a preprint answering this question last year, and now it has been extensively revised, refocused, and generalized. Read more here: doi.org/10.1101/2024... (1/7)

3 months ago 76 18 1 2
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A Network of Biologically Inspired Rectified Spectral Units (ReSUs) Learns Hierarchical Features Without Error Backpropagation We introduce a biologically inspired, multilayer neural architecture composed of Rectified Spectral Units (ReSUs). Each ReSU projects a recent window of its input history onto a canonical direction ob...

Move over ReLU 🚀
Meet **ReSU** (Rectified Spectral Unit): a biologically inspired, self-supervised unit for learning from dynamical data. A backprop-free multilayer ReSU network learns predictive features and recapitulates *Drosophila* vision.
To appear at AAAI: arxiv.org/abs/2512.23146

3 months ago 27 10 1 0
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2025: A Review of the Year in Neuroscience Enlightening the brain

Just published my review of neuroscience in 2025, on The Spike.

The 10th of these, would you believe?

This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more

Enjoy!

medium.com/the-spike/20...

3 months ago 143 66 6 11
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Rethinking the centrality of brain areas in understanding functional organization Nature Neuroscience - Parcellation of the cortex into functionally modular brain areas is foundational to neuroscience. Here, Hayden, Heilbronner and Yoo question the central status of brain areas...

New Perspective from myself, Sarah Heilbronner and @myoo.bsky.social . “Rethinking the centrality of brain areas in understanding functional organization” in Nature Neuroscience. 🧵

rdcu.be/eVZ1A

3 months ago 253 99 9 10
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Not playing around: Why neuroscience needs toy models Amid the rise of billion-parameter models, I argue that toy models, with just a few neurons, remain essential—and may be all neuroscience needs.

Amid the rise of billion-parameter models, I argue that toy models, with just a few neurons, remain essential—and may be all neuroscience needs, writes @marcusghosh.bsky.social.

#neuroskyence

www.thetransmitter.org/theoretical-...

3 months ago 61 26 4 3

Our paper on data constrained RNN that generalize to optogenetic perturbations now citable on eLife:
doi.org/10.7554/eLif...

4 months ago 43 18 1 2
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Young PI Symposium 2026 Visit the post for more.

📢Are you a young PI or senior postdoc in neuroscience looking to embark on the challenging journey of starting your own lab?

📆Then save July 5, 2026 in your calendar and join us in Barcelona for the second Young PI Symposium.
youngpisymposium2026.com

4 months ago 7 5 0 3
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Dimensionality reduction may be the wrong approach to understanding neural representations. Our new paper shows that across human visual cortex, dimensionality is unbounded and scales with dataset size—we show this across nearly four orders of magnitude. journals.plos.org/ploscompbiol...

4 months ago 224 65 7 10
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Three types of remapping with linear decoders: A population-geometric perspective Author summary Place cells of the hippocampus form unique activity patterns in different environments, a process called remapping. However, it is not clear what the relationship is between changes in ...

I’m happy to share some recent work out in PLOS Computational Biology with @guille-martin.bsky.social and Christian Machens at @champalimaudr.bsky.social . We use neural coding and population geometry to study different perspectives on hippocampal remapping.

journals.plos.org/ploscompbiol...

4 months ago 28 6 1 1

That’s it, thanks for reading along. There’s a lot more details in the paper about the framework and its relationship to the multitude of experimental and computational studies of hippocampal remapping. Please let us know what you think!

4 months ago 0 0 0 0
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Overall, all three remapping mechanisms are likely to be accurate depictions of hippocampal activity changes under different conditions. More generally, this perspective is not limited to the hippocampus and can be used to understand neural variability in other brain areas as well!

4 months ago 0 0 1 0
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In the paper, we simulate several examples of each remapping type in RNN models and quantify the types of neural activity patterns underlying them.

4 months ago 0 0 1 0