Figure with title "Figure 2. Spline Model Depicting New-Onset Hypertension at 2 to 7 Years Post Partum With Body Mass Index (BMI) vs Systolic Blood Pressure (SBP) Genetic Risk" displaying two lines representing BMI groups <25 and >=25.

In a US cohort, higher systolic #BloodPressure genetic risk was associated with new-onset #Hypertension after pregnancy, but elevated postpartum body mass index and hypertensive disorders of pregnancy were stronger risk factors.

ja.ma/4s7jJxK

📣 We’re hiring!
My team at Mass General Brigham / @broadinstitute.org is growing:

• Postdoc (PhD; human 🧬 & multi-omics)
• Research fellow (clinical trials & epi; 2-yr)
• Computational associate

Join a collaborative, high-impact 🫀 precision medicine team.
DM or email mhonigberg@mgb.org

A JAMA Cardiology article, published November 9, 2025, titled "Clonal Hematopoiesis—An Opportunity to Confront the Heart Failure Epidemic" by Domingo A. Pascual-Figal and José J. Fuster, discusses the relationship between CHIP and heart failure.

💬 Invited Commentary: Flynn et al find non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) mutations most strongly associated with heart failure risk in UK Biobank data, supporting gene-specific risk assessment.

#AHA25 @ahascience.bsky.social

ja.ma/4p56SeB

JAMA Cardiology graph titled, "Clonal Hematopoiesis and Incident Heart Failure." It shows mediation analyses for clonal hematopoiesis of indeterminant potential(CHIP) and incident heart failure. Coronary artery disease, atrial fibrillation and combined model has highest %

Non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) subtypes—including TET2, ASXL1, JAK2, and spliceosome genes—demonstrated higher association with incident heart failure compared to DNMT3A.

#AHA25 @ahascience.bsky.social

ja.ma/3JQSveI

November issue now live, with Reviews on:
-Clonal haematopoiesis in cardiovascular disease
-Regulators of cardiomyocyte proliferation
-Extracellular vesicles in cardiovascular homeostasis and disease
-Factor XI inhibitors for venous and arterial thromboembolism
www.nature.com/nrcardio/vol...

In this exploratory analysis, treatment with low-dose colchicine was associated with an attenuated annual clonal growth in TET2 CH. These findings suggest the potential for colchicine to curb the proliferative advantage of key CH driver mutations https://bit.ly/3HWJL5M

#ESCCongress #WCCardio #JACC

A graph titled Figure 1. Cumulative Incidence of Myocarditis and Pericarditis During Follow-Up by Clonal Hematopoiesis of Indeterminate Potential (CHIP) Status displays three lines: Large CHIP, Any CHIP, and No CHIP, charting cumulative incidence over follow-up time.

Among middle-aged adults, clonal hematopoiesis of indeterminate potential (CHIP) was linked to an increased risk of developing myocarditis and pericarditis.

#ESCCongress #WCCardio

ja.ma/45RBaJG

New report that CHIP (clonal hematopoiesis of indeterminate potential, blood stem cell clones that increase with age) is an independent risk factor for myocarditis and pericarditis, promoting inflammation #ESC2025
@jama.com

jamanetwork.com/journals/jam...

(6/X)

Our findings suggest CHIP remains relevant into later life & underscore its heterogeneity.

Paper (OA): www.jacc.org/doi/10.1016/...

Editorial: www.jacc.org/doi/10.1016/...

Come see @danielezzat.bsky.social 's presentation #ESC2025 (29 Aug 10:15a)!

@mghcvrc.bsky.social @broadinstitute.org

(5/X)

HRs for CHIP were comparable or greater than those for other conventional CVD risk factors (e.g., 👇)

In addition, we examined alternate thresholds of variant allele frequency to define CHIP; associations generally ⬇️ w/ smaller clone size

(4/X)

Key CHIP subtypes were associated w/ adverse CV events

Consistent w/ our prior work, TET2 CHIP associated w/ CHD & HFpEF

👀 ASXL1 CHIP ➡️ HFrEF (aHR >3)

Notably, no associations were seen when we lumped all CHIP types together, underscoring its heterogeneity

(3/X)

We therefore examined ~6,700 👵👵 from the Women's Health Initiative Long Life Study (median age 80 y) and sequenced blood cells ~4,500x in each participant to accurately detect 🔍 and quantify CHIP

Women were followed for ~10 y for coronary heart disease and several secondary outcomes

👇

(2/X)

CHIP = aging-related acquired blood stem cell mutations that predispose to blood cancers

We + others have shown that CHIP also associates w/ ⬆️ CVD risk

But previous work suggested attenuation of associated risk in older adults, who have highest risk of both CHIP + CVD

The lab's first sim pub of #ESC2025 is now online in
@jaccjournals.bsky.social #JACC!

jacc.org/doi/10.1016/...

Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study

👇

(1/X)

Fantastic joint lab retreat today w/ @pnatarajanmd.bsky.social @zhiyu.bsky.social & Akl Fahed labs

Honigberg lab is rapidly growing 📈 👇

@mghcvrc.bsky.social @mgbwomenheart.bsky.social @mgbresearch.bsky.social

Women's Heart Health Fellowship Program The Women’s Heart Health Fellowship Program at Massachusetts General Hospital provides advanced training in the prevention, diagnosis, and treatment of heart disease in women.

Now accepting applications for the 2026-2027 Women's Heart Health Program Fellowship!🫀Click here for details: massgeneral.org/heart-center...

@mdharringtonc.bsky.social @emilyswlau.bsky.social @mchonig.bsky.social

SCAD Patient Symposium: Your Heart, Your Story Join us October 18, 2025 for a day of building community with your peers, and hearing from renowned experts about all things SCAD.

Registration is now open!📣We're co-hosting a patient SCAD Symposium with @scadalliance.bsky.social in October 🫀
Please click on the event page to register & for all of the details! massgeneral.org/heart-center...
@emilyswlau.bsky.social @mdharringtonc.bsky.social @mchonig.bsky.social

The latest from our @americanheart.bsky.social -funded BUSY-BP study, led by MGH medicine resident Lulu Belak, now in Obstet Gynecol @greenjrnl.bsky.social

In Black + Latina 👭, burden of health-related social needs in pregnancy was associated w/ adverse 🤰 outcomes

journals.lww.com/greenjournal...

The inaugural MGB & Inova YIA was a huge success 🎉Please join us in congratulating 👏👏
Basic & Translational category:
Winner: Maria Pabon (BWH)
Honorable Mention: Amelie Vromman (BWH)
Clinical Research category:
Winner: Meesha Vullikanti (Yale)
Honorable Mention: Izza Shahid (Houston Methodist)

Huge congrats to @massgeneralbrigham.bsky.social MGH medicine resident Amanda Jowell for receiving a top resident abstract award for her analysis of female-specific CVD risk factors in severe hypercholesterolemia 🏆 @mgbwomenheart.bsky.social @mghcvrc.bsky.social

Big congrats to Maria Pabon for winning the inaugural @mgbwomenheart.bsky.social / @ishvnews.bsky.social Young Investigators' Award (basic/translational category) for her work on endothelial cell transcriptomics in preeclampsia (www.ahajournals.org/doi/10.1161/...)! 🏆 @cardioob.bsky.social

Genetic Risk & 1st-Trimester CV Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women

#CardioObstetrics #CardioSky #JACC
www.jacc.org/doi/10.1016/...
@mchonig.bsky.social @garimasharmamd.bsky.social @jaccjournals.bsky.social @csilvers.bsky.social @mdharringtonc.bsky.social

Our latest on 🫀 health, 🧬, and 🤰 now out in @jaccjournals.bsky.social #JACC

First-trimester cardiovascular health strongly associates with development of hypertensive disorders of 🤰 (HDP)

overall and across levels of HDP genetic risk

www.jacc.org/doi/10.1016/...

#CardioObstetrics #CardioSky

We love our team ❤️ Check out @mchonig.bsky.social's latest review!

… posted prematurely/in error without acknowledging the awesome work of lead author and overall rockstar @artschuermans.bsky.social !

Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target - Nature Reviews Cardiology In this Review, Schuermans and Honigberg highlight the involvement of clonal haematopoiesis of indeterminate potential (CHIP) in cardiovascular diseases, such as atherosclerosis and heart failure, and...

Check out our latest review on clonal hematopoiesis🩸🧬 and cardiovascular disease 💔 now out in @natrevcardiol.bsky.social

www.nature.com/articles/s41...

Full text link: rdcu.be/ef9VW

@mgbresearch.bsky.social @mgbwomenheart.bsky.social

@mgbwomenheart.bsky.social

Role of Cardiovascular Health in Maternal Health Explore the role of cardiovascular health in maternal well-being. Learn warning signs, improve communication, and access life-saving tools.

Check out our latest episode of HeartBEATS from the @americanheart.bsky.social focused on peripartum cardiomyopathy 🤰🫀 #PPCM ! @cardioob.bsky.social

professional.heart.org/en/education...