Deutschlandkarte mit Planungsorten von Gaskraftwerken, Bohrungen und Pipelines. Es finden sich vor allem in der Nordsee und in allen Teilen Westdeutschlands Planungen

Die Bundesregierung will geheimhalten, wo sie neue fossile Infrastruktur in Deutschland plant.

Wir schaffen Transparenz und zeigen, wo neue Kraftwerke, Bohrungen, Pipelines und Flüssiggas-Terminals entstehen sollen – und wie ihr dagegen aktiv werden könnt: fragdenstaat.de/aktionen/cli...

Oben: Porträt von Jonathan Fröhlich vor dem Hintergrund einer mit bunten Klebenotizen beklebten Wand. Unten: Die Überschrift des im Post verlinkten Artikels "Ressourcenreiches Repositorium“, gefolgt von dessen Vorspann „Wie finde ich gute Projekte, wie halte ich spannende Vorträge, wie werde ich ein guter Mentor? Jonathan Fröhlich hat eine Liste mit über 200 Tipps zusammengestellt.“ Links daneben befindet sich ein Icon mit Smartphone und Magazinseite sowie der Schriftzug „Kostenlos online lesen!“. In der rechten unteren Ecke befindet sich das Laborjournal-Logo.

Ausschnitt aus dem verlinkten Artikel.

Wissenschaft umfasst neben Labor und Publikationen auch Präsentationen, Mentoring und Karriereplanung. Jonathan Fröhlich stellt dafür über 200 Ressourcen frei zur Verfügung und teilt somit eine 8 Jahre gefütterte Schatzkiste: www.laborjournal.de/editorials/3...
#Laborjournal #LifeSci #OpenScience

Had a cracking lab meeting this morning with our latest epigenome editing results (new tools we're trying for the 1st time). Reminded me we're organizing an awesome symposium in Paris in Nov! Here's our updated flyer (new speaker @dfachinetti.bsky.social). Please share! ctrlepiedit.sciencesconf.org

Hi all! 👋
leeboratory.bsky.social and I are recruiting a VIP³ postdoc to join our teams and decode the genetic logic of how blastoids transit to the post-implantation stage. MolBio, genetics and computational approaches. If this sounds like you (or someone you know), we’d love to hear from you! 🚀

I'm really excited to speak at this year's EMBL Transcription and Chromatin meeting in August!

Very cool story! Congratulations, Elzo & team!

Congratulations, Agnese! I wish you a smooth start!

I'm really excited about this meeting on epigenetic editing!

Congratulations, Tugce and team! Nice to see this story out!

I’m thrilled to share that my PhD work has been just published in Cell. After a long and bumpy ride, we uncovered the core function of nuclear speckles -splicing of GC-levelled exons- and traced the evolution of this gene architecture and condensates themselves to amniotes.

1/
In 12 Tagen möchte die Bundesregierung ~300 Millionen an die Firma STARK zahlen, die u.a. Peter Thiel, Döpfners & der CIA gehört.

Es geht nicht um irgendein Produkt, sondern um Waffen zum Schutz unseres Landes. Es droht ein zweites “Palantir”.

Das sollten wir nicht zulassen!

Wellcome to the XCI field. Registration will open in March.

Ad for a postdoc position in centromere biology with colorful chromosomes and centromeres made out of FIMO.

🧪 My lab has an opening for a postdoc position soon! Please share/get in touch!

📣NuQuest consortium update: Our first joint publication is out!Review on quiescence—A milestone for our initiative laying out the scientific groundwork & collaborative vision for our MSCA-DN application coordinated by @jlugiessen.bsky.social 1/n
www.mdpi.com/3700996
#NuQuest #MSCA #DoctoralNetwork

Wellcome Connecting Science Synthetic Biology for Health and Sustainability conference Conference dates: 11-13 March 2026 Highlights include our keynote lectures as follows Talk title: "Combining protein engineering and synthetic biology to develop a therapeutic bacteria to treat lung diseases" by Luis Serrano, Centre for Genomic Regulation, Spain Talk title: "Towards sustainable, bio-sourced polymers" by Kristala Prather, Massachusetts Institute of Technology (MIT), USA

Secure your in-person place at Synthetic Biology 2026! #SynBio26

Register by 9 February ⏰

Hear #SynBio research from globally leading scientists. Don’t miss our “Meet the Editors” session—your chance to get insights on the publication and peer-review process.

📎 bit.ly/43nlbBW
#ALife ⚙️🧫

Congratulations, Scott and team!

Top: scheme of synthetic antisense locus; bottom: experimental setup where a Dox pulse induces antisense-mediated repression that leads to a sustained down-regulation of the sense gene.

⚒️ Through constructing a synthetic antisense locus, Verena then showed that gene repression, induced by antisense transcription can be stable for several days, when ESCs differentiate.

genome browser tracks of nascent transcription of the region surrounding the Nfatc4 gene for 3 time points: at day 0 transcription mostly comes from an antisense transcript, which disappears at day 4, where the Nfatc4 gene now is transcribed.

🧬 Till then found experimental evidence for promoter-repression by antisense transcription through a genome-wide analysis of nascent transcription during ESC differentiation. Here promoter-overlapping antisense pairs show mutual exclusive expression.

Scheme of convergent antisense locus and scheme of expression memory where one antisense partner is high and the other one is low until they switch and memory is lost.

💻 Through extensive stochastic simulations 📈 Verena showed that (convergent) antisense transcription ➡️⬅️ can store stable memory, if antisense txn goes through the gene promoter and induces a stable repressed state.

Antisense transcription can induce expression memory via stable promoter repression - Genome Biology Background The capacity of cells to retain a memory of previous signals enables acquisition of unique fates and adaptation to their environment. The underlying gene expression memory can arise from mu...

⚠️ The final work of two former PhD students Till @tschwammle.bsky.social and Verena @verenamutzel.bsky.social is out!
➡️⬅️ They dissect how memory can arise from antisense transcription using mathematical modelling 💻, genomics 🧬 and synthetic biology ⚒️! link.springer.com/article/10.1...

I'm excited to participate in the upcoming Wellcome conference on synthetic biology 🛠️🧬 with a great lineup of speakers! It's still possible to sign up, as the abstract deadline has been extended until January 5th 📄 - join us!

Escape from X inactivation is directly modulated by Xist noncoding RNA Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

Thanks @pasquelab.bsky.social and his team for this collaboration.

Poster advertising the 6th X-inactivation meeting from Oct 19-23 2026 in Sapporo, Japan. The organizers are Asato Kuriowa, Edda Schulz, Ikuhiro Okamoto, Rafael Galupa, Takashi Sado, Mitinori Saitou.

📣 SAVE THE DATE
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social

New paper from the lab: we’re using long-read sequencing to disentangle isoform complexity at allele-specific loci 🧬💡
Here, we combine the PacBio Iso-Seq workflow with the established WhatsHap phasing approach to assign long reads to the correct allele in polymorphic F1 mouse hybrids.

🧬 Interested in dissecting dose-dependent transcriptional regulation through epigenome editing and synthetic biology for your PhD? Apply by 07.01.2026 to join the lab of @eddaschulz.bsky.social @molgen.mpg.de & #IMPRS-BAC #gradschool.

👉 www.molgen.mpg.de/5099133/schu...

Robust pan-junctional reinforcement preserves the gut epithelial barrier under mechanical stress Epithelia are specialized tissue barriers that safeguard the organism's internal milieu from the hostile external environment, a function critically dependent on intercellular junctions. In the colon,...

Ever wondered how adult organs preserve epithelial barrier integrity while continuously exposed to mechanical stress? We tackled this question in our new preprint – led by our brilliant PhD student Vishnu Krishnakumar! (1/11)
🔗 www.biorxiv.org/content/10.1...

coffee breaks inspire the coolest things, no? It certainly inspired this wonderful project – a kids book on a robin that takes you under its wing on its journey to their wintering grounds. gorgeously illustrated @co-la.bsky.social and beautifully written by a #dreamteam within @sfb1372.bsky.social

Enhancer-promoter compatibility is mediated by the promoter-proximal region Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...

What is a promoter? And how does it work?

We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters

www.biorxiv.org/content/10.1...