Hallucinated citations are polluting the scientific literature. What can be done? Tens of thousands of publications from 2025 might include invalid references generated by AI, a Nature analysis suggests.

Tens of thousands of publications from 2025 might include invalid references generated by AI, a Nature analysis suggests. #ResearchPublishing #Academicsky 🧪

Start Good Friday right: With intestinal tuft cells that refresh immune memory to prepare for parasite re-infection by Jakob von Moltke in Immunity www.cell.com/immunit... 🧪

From Data and Models to E-Health | SBMC 2026 Website of the 10th international conference on Systems Biology of Mammalian Cells SBMC 2026 on May, 4th – 6th in Mannheim.

Today I was very excited to be invited to give a talk at this year's SBMC in Mannheim, Germany. The conference has a strong focus on biomedical AI and eHealth, so please come join us, and spread the word: www.lisym-cancer.org/sbmc2026 🧪

Scanpy and Seurat produce (slightly) different results when analysing the same scRNA-seq data. Lior Pachter thoroughly quantified differences in Cell Systems and rightfully concluded that we need max. transparency for max. reproducibility: www.cell.com/cell-sy... 🧪

How? (honest curiosity)

From Data and Models to E-Health | SBMC 2026 Website of the 10th international conference on Systems Biology of Mammalian Cells SBMC 2026 on May, 4th – 6th in Mannheim.

Today I was very excited to be invited to give a talk at this year's SBMC in Mannheim, Germany. The conference has a strong focus on biomedical AI and eHealth, so please come join us, and spread the word: www.lisym-cancer.org/sbmc2026 🧪

Impressive Science Immunology paper from Hélène Moreau Inserm showing that macrophages regulate extracellular matrix remodelling in the tumor microenvironment and Tcf4 and Col3a1 are indicative of T cell and neutrophil infiltration:
www.science.org/doi/... 🧪

In a meeting yesterday, someone said: "Quick-and-dirty approaches are usually just dirty" – and I thought this was great sentiment.

Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans Langer et al. show that GLP-1 medicines mildly reduce absolute muscle mass but improve relative mass and running performance in mice. Despite similar changes to body weight, GLP-1RA affects the muscle proteome differently compared to calorie restriction. A human pilot trial shows that muscle strength is maintained during GLP-1RA treatment.

Online now: Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans

Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids Nature Microbiology - Clostridium perfringens lacking perfringolysin O toxin isolated from preterm infants metabolizes human milk oligosaccharide disialyllacto-N-tetraose to produce metabolites...

Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids. Great paper from Newcastle University out now in Nature Microbiology: www.nature.com/artic... 🧪

ER remodelling is a feature of ageing and depends on ER-phagy Nature Cell Biology - Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

New research from @vumedicine.bsky.social in Nature Cell Biology shows the contribution of Endoplasmic Reticulum remodelling to proteostasis, lipid-homeostasis and lifespan across aging species:
www.nature.com/artic... 🧪

Lipid-dependent accrual of a subset of monocyte-derived macrophages is essential for tissue regeneration Nature Metabolism - A distinct lipid-laden subset of monocyte-derived macrophages regulates hepatocyte proliferation and liver regeneration in injured livers, via CD36-mediated signalling.

Pleased to see that we have another subset of macrophages in the liver: LIMMs, they are lipo-inflammatory monocyte-derived macrophages, and a much needed distinction from our LAMs: www.nature.com/artic... 🧪 Nature Metabolism

🧵 See 👇 our new preprint on shared and organ-specific gene expression programs of fibrotic diseases 🧬

📄 Paper: doi.org/10.64898/202...

📊 Explore the data: organfibrosis.saezlab.org

Obese people with inflammatory bowel disease may benefit from intermittent fasting, a randomized, controlled clinical trial from UCalgaryMedicine suggests in @aga-gastro.bsky.social: www.gastrojournal.or... 🧪

This new review from Core Investigator @christophthaiss.bsky.social & Innovation Investigator @maayanlevy.bsky.social maps how gut metabolites shape diseases from IBD to cancer, and lays out a framework for using them as therapies.

Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cells The suppressive tumor microenvironment (TME) severely limits CAR T cell therapy in solid tumors. Yagel et al. develop armored hTREM2 CAR T cells that target TREM2+ tumor-associated macrophages (TAMs) rather than tumor antigens and locally secrete interleukin-12 (IL-12) via a TME-responsive biosensor. These cells deplete TAMs, reprogram the TME, and drive tumor regression without systemic toxicity, offering a promising strategy for broad solid tumor therapy.

Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cells

👀 Very decent Immunity paper from Danny Saban on how tissue-resident macrophages regulate eye pressure through remodelling of extracellular matrix; with lots of cool microscopy data: www.cell.com/immunit... 🧪

Interesting @cp-cell.bsky.social paper from @ucsfohns.bsky.social on inter-personal variability of immune states in healthy humans. TL;DR: Microbiome & metabolite variability is associated with differential interferon responses, which are stable over time: www.cell.com/cell/fu... 🧪

Really cool, I forwarded the unedited proof version already to my group to read. We were all delighted. As always, well written and conceptualised!

🚀 New in Communications Biology:
Generative models of cell dynamics - from Neural ODEs to Flow Matching
www.nature.com/articles/s42...

We discuss modeling single-cell dynamics beyond snapshots: from cont-time Neural ODEs to simulation-free flow matching for scalable pop modeling.

Out now in Cell Metabolism: Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism www.cell.com/cell-me... 🧪

Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance Nature Metabolism - Neri et al. develop elegant tools to understand how the sympathetic nervous system regulates intrascapular brown adipose tissue (iBAT) function. Using these tools, they find...

Brown fat (BAT) goes on your nerves? Rather the opposite: Two types of neurons separately regulate glucose tolerance and blood flow / thermogenesis. Cool paper from Lori Zeltser, PhD in Nature Metabolism: www.nature.com/artic... 🧪

Great resource, thanks a lot for compiling! And to students: I was asked about characteristics between mammalian vs. bacterial kinases in my PhD defence, so you better have a look 🤓

Benchmarking EGF signaling pathway inference using phosphoproteomics and kinase-substrate interactions - Nature Communications To what extent can large-scale approaches accurately reconstruct classic signaling pathways? Here, authors revisit the EGF pathway using phosphoproteomics and kinase-substrate interactions

Interested in kinase-driven signaling interactions? Check out our (now peer-reviewed) paper together with @savitski-lab.bsky.social on reconstructing signaling networks from phosphoproteomics data and prior knowledge:
➡️ doi.org/10.1038/s414...

Evaluating the analytical performance of direct-to-consumer gut microbiome testing services - Communications Biology Comparative analysis of DTC gut microbiome testing services reveals significant methodological variability, underscoring the need for standardized reference materials and guidelines to ensure reproducibility and reliability in commercial microbiome testing.

Results and health assessments from gut microbiome home-testing kits vary whether they are produced by the same or different manufacturers. The findings, published in Communications Biology, highlight the need for caution when interpreting or acting on test results, according to the authors. 🧪

Thanks to @natrevmicro.nature.com for discussing our work on gut microbiome control of HIV immunodeficiency as research highlight: www.nature.com/artic... 🧪

How do authors want to use AI for review? - EMBO Reports EMBO Reports - A survey of researchers who compared AI-generated scientific reviews with journal-agnostic human peer review reveals that they overwhelmingly prefer using AI as a self-checking tool...

This is such a great and timely survey on author's perception of peer review vs AI scientific review. A collaboration between @reviewcommons.org and @qedscience.bsky.social. The geek in me would have liked to see the distributions in the response scores ;). link.springer.com/article/10.1...

Polystyrene microplastics hamper efferocytosis through accumulating methylglyoxal. Overexpression of glyoxylase-1 rescues the phenotype. Great work by Ana Codo from @mskcancercenter.bsky.social et al. open access in Immunity: www.cell.com/immunit... 🧪

Great review on efferocytosis and metabolic reprogramming in Springer Nature Cell Death & Disease from Karen Cristina Oliveira et al. from São Paulo State University:
www.nature.com/artic... 🧪

Those who know me, know I’m not someone who changes his preferences & behaviors lightly. As Ron Swanson said, “I regret nothing. The end.” Well, let me tell you about our new study, out from The Perry Lab @mskcancercenter.bsky.social in @cp-immunity.bsky.social, which is the exception. /1