New preprint out! We made a #Plasmodium knowlesi A1-H.1 #transcriptome time course for asexual blood stages🩸. tinyurl.com/mwd9b8vx
👩‍💻Webtool to compare temporal expression to P. vivax: tinyurl.com/bdz2ndsj

@itmantwerp.bsky.social @eknuepfer.bsky.social @cortesmalaria.bsky.social

It’s beginning to look a lot like Christmas! 🎵
Merry Christmas and happy holidays to everyone! 🎄🎁🍾
The Epis send you warm holiday wishes from our brand-new lab location @www.pcb.ub.edu ✨✨✨

Thermal and non-thermal stress conditions activate the Plasmodium falciparum AP2-HS-dependent heat-shock response To preserve proteome homeostasis and survive at higher-than-optimal temperatures, organisms have evolved the conserved heat shock (HS) response (HSR), characterised by increased expression of specific...

Curious about which thermal 🌡️and non-thermal 💊conditions activate the AP2-HS-dependent heat-shock response in Plasmodium falciparum? Check out our new preprint in Biorxiv!📊🧪

www.biorxiv.org/content/10.1...

Double congratulations!

🧬We also show that maintenance of heterochromatin at the ap2-g locus depends on the sequences from the putative ap2-g promoter. ▶️Go ahead and take a look! You'll find more juicy details in the paper!! 🤗

a brown dog is sitting on a blanket and looking at the camera with the words `` wait what ? '' ALT: a brown dog is sitting on a blanket and looking at the camera with the words `` wait what ? ''

Heterochromatin formation is very efficient at var upstream sequences, but it is inefficient for ap2-g 5'CDS sequences, which require looooong DNA sequences and only occurs in a few parasites. Other sequences tested cannot nucleate heterochromatin formation at all! 🤪

💡We found that DNA sequences of genes such as ap2-g or var are sufficient to trigger heterochromatin formation when integrated in an euchromatic locus 😯

Heterochromatin de novo formation and maintenance in Plasmodium falciparum Author summary Proper regulation of gene expression is crucial for the functioning of all organisms. One key mechanism involves modifications in the structure of chromatin, the DNA and proteins comple...

📣Rush to read our latest paper!! journals.plos.org/plospathogen.... You'll learn why #heterochromatin is formed and maintained in specific regions of the Plasmodium falciparum genome and not others 🧵⬇️

Our colleagues and us have been abducted from the lab!!! 🆘👽 If you see these ISGlobaliens around Barcelona, don't be shy and ask for a ride in their fantastic UFO! 🤩🛸

Heterochromatin de novo formation and maintenance in P. falciparum In the malaria parasite Plasmodium falciparum, the expression of many genes is regulated by heterochromatin (HC) based on the histone mark tri-methylation of histone H3 lysine 9 (H3K9me3). HC assembly...

📣📣See our new preprint in Biorxiv, in which we explore the role of the primary DNA sequence 🧬 in de novo heterochromatin formation and maintenance 🔍📊🧩
www.biorxiv.org/content/10.1...

Welcome to our new Bluesky account!!👋😊Lots of science and fun ahead! 🔬🧪🥼🤩