Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.
Thanks Stefan!
Thanks Mark!
Finally, I thank everyone involved, including Cristian Marchant and Mariana Osswald in our lab at i3S @i3suporto.bsky.social and all our collaborators from the @ybellaichelab.bsky.social and the Xiaobo Wang labs.
and no more spoilers! Check it out to see how we found that RhoGAP15B locally suppresses RhoA-Myosin at the front of the cluster, creating a relaxed zone that promotes protrusive activity, letting leader cells move forward while the cluster stays coordinated.
We found that multiple RhoGAP15B genetic perturbations indeed disrupt normal border cell migration
and were intrigued by the accumulation of a RhoA inhibitor, RhoGAP15B, at protrusions in leading cells.
We systematically analyzed the endogenous subcellular patterns of Rho GTPase regulators (RhoGAPs and RhoGEFs) to understand how the cytoskeleton is locally tuned to drive collective cell migration.
Drosophila border cells are beautiful to watch… but far from easy to image. Kudos to the brave and skilled @vitoryang.bsky.social, who took on the challenge of establishing border cell migration imaging in the lab! His movies are astonishing, and now our first-ever study on #cell #migration is out!
I am so happy to share that my previous preprint is officially out as a Report in JCB. 🩵
Hop in to find out more about how cells move as an invasive cluster 🧬
How do tissues maintain their integrity?
Let's discuss epithelial fractures!
High tissue tension can cause cells to break their contacts, leading to rupture!
Research in #rarediseases using model organisms is of utmost importance to unravel the underlying molecular mechanisms of disease @rarediseaseday.bsky.social
What music should we play to our cells? This was the start of an amazing journey from @ivaskalab.bsky.social at @turkubioscience.bsky.social with Jasmin Kaivola and collaborators @sarawickstrom.bsky.social and others to explore larynx cancer mechanosensitivity!
www.nature.com/articles/s41...
Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches
May 18-22, 2026 Roscoff, France
Abstract deadline: January 31, 2026
Apply here: cjm.sb-roscoff.fr/en
How do cells orchestrate themselves to achieve a directional movement as a group?
Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
Mitosis has a timing system. If chromosomes attach properly, cells divide on schedule and keep proliferating. If attachment is slow or incomplete, the delay is recorded — and daughter cells stop dividing.
We explore this link in our new preprint.
🔗 www.biorxiv.org/content/10.6...
Cartoon with principle of Flash-away and images of cells
FLASH-AWAY: Intrabody-Directed Targeting of Optogenetic Tools for Protein Degradation: pubs.acs.org/doi/10.1021/...
It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social
Job Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
Our latest research in collaboration with @nilssonlab.bsky.social, @andrea-musacchio.bsky.social and Mathieu Bollen reveals a new regulatory strategy employed by cells to control PP1 in mitosis. Check it out in @currentbiology.bsky.social
www.sciencedirect.com/science/arti...
Interested in cell migration and developmental biology-check out this PhD opportunity!
www.findaphd.com/phds/project...
So: can a cell hold hands with itself…and do we care? YES and YES! Read on to learn WHY, HOW, and what this has to do with…PARIS (and tree-hugging)? Swansong of Dr. Anamika; Hannah Kim on drums; and fantastic undergrads (Margaret/Lauren) ! 1/n
advanced.onlinelibrary.wiley.com/doi/10.1002/...
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
How can we use cell shapes and geometry to study mechanics of tissues?
I'm @juliaeckert.bsky.social, and with this thread, I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀. #EpithelialMechanics
Our new collection offers cell biologists practical, expert-driven guidance and best practices in the design, execution, and analysis of experiments, and the subsequent communication of their results to their peers. 👉 rupress.org/jcb/collecti...
#Reproducibility
Happy to share a new publication: an introduction to comparative oncology in @natrevcancer.nature.com. Thanks to the leaders in the field for welcoming me as an invertebrate researcher.
rdcu.be/etKdN
Epithelial morphogenesis is all about how epithelial tissues develop unique shapes and structures! I'm @nehaghosh.bsky.social and will share some research in this area.
