An amazing team effort to provide a highly tractable system to study human pluripotent and early developmental transitions, including those driving #GermCellTumorigenesis and #EpigeneticInheritance.

Cheers to Philipp Dexheimer/ philippdexheimer.com who instilled his art into our journey towards in vitro modelling of human pluripotency transitions through the germline 🌀.

High resolution multi-scale profiling of embryonic germ cell-like cell derivation reveals pluripotent state transitions in humans We report the first fully defined system to efficiently convert hPGCLCs to a pluripotent stem cell state. We track pluripotent state transitions by multi-omics analysis and provide a high-resolution m...

Happy to share that our paper is out and we made the cover!🎉

📄Paper: www.cell.com/stem-cell-re...
💻Github: github.com/GiuseppeTest...

New in vitro model provides a highly tractable system to study human pluripotent & early developmental transition. High resolution multi-scale profiling of embryonic germ cell-like cell derivation reveals pluripotent state transitions in humans https://ow.ly/hssJ50XMx1s

Human Technopole | ISSCR