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Posts by Vindigni Lab

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Congratulations @seppai99.bsky.social for defending her thesis last week!!! Such an honor having her in the lab and excited about the next steps in her career!!!

8 months ago 7 0 1 0
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Will the Senate Save NIH? Rescuing biomedical research is every bit as important as saving Medicaid.

The proposed budget slashes NIH by ~40%, devastating medical research, clinical trials, treatment breakthroughs—life-saving work.

Thousands of lives at risk for tax cuts for the rich? NO THANKS.

Tell your senators to oppose the cuts HERE:
zurl.co/qiKdX


zurl.co/RCR0y
#CutsCostLives

9 months ago 166 81 2 1

Call your legislators to stop slashing the budget of federal funded research in the “Big Beautiful Bill”. Find numbers @5calls.org

9 months ago 0 1 0 0
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Congratulations Isabelle for winning the Future of Science Fund at the Keystone!! We are very honored to have such a fantastic student in the lab!!!

11 months ago 13 2 3 0
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Congratulations Isabelle for winning the Future of Science Fund at the Keystone!! We are very honored to have such a fantastic student in the lab!!!

11 months ago 13 2 3 0
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Wrapping up an insightful conference on DNA Replication Gaps, Cancer, and Disease! 🎉 Congrats to our Future of Science Fund winners, Larissa Milano and @seppai99.bsky.social! Your achievements inspire us. 🌟 #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social

11 months ago 12 4 2 2
DNA Repair | The replication stress response: mechanisms and functions | ScienceDirect.com by ElsevierScienceDirect High-fidelity DNA replication is constantly challenged by a diverse range of obstacles, including endogenous lesions and secondary structures in the DNA template, tightly bound protein-DNA complexes, ...

Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social.
www.sciencedirect.com/special-issu...

1 year ago 40 14 1 1
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An interesting collaboration with the @vindignilab.bsky.social on the mechanism of resection at gaps. Spoiler alert: the MRE11 complex acts very differently at gaps vs. at DNA breaks genesdev.cshlp.org/content/earl...

1 year ago 26 3 0 0
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Check out our new paper led by @seppai99.bsky.social from the Vindigni Lab in collaboration with @cejkalab.bsky.social delving into the role of nucleases resecting ssDNA gaps generated by PARPi. You can read more here: genesdev.cshlp.org/content/earl...

1 year ago 33 5 0 1
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Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇

1 year ago 38 34 3 1
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Scientists warn of long-term damage as Trump’s orders slow research By blocking announcements in the Federal Register, the administration is keeping experts from meeting to evaluate funding proposals.

www.washingtonpost.com/science/2025...

1 year ago 0 1 0 0

this is breaking through
keep up the full court press
* patients harmed right now
* hurts our economy right now
* destroys our STEM infrastructure
* gift to global competitors and adversaries
* dirty tricks by bureaucrats who failed HS chemistry twice

1 year ago 25 14 1 0

a great way of framing the issue — the bureaucrats are scheming to wreck science they can’t criticize or understand👇🏽

“This really feels like an evil way of using bureaucracy against the process of science, to the contrary of what they say they are doing — streamlining bureaucracy,” Cooper said.

1 year ago 8 5 0 0
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Federal Register Blackout Blocks NIH Funding New strategy is like pouring 'cement in the pipes of the federal funding infrastructure'

Federal Register Blackout Blocks NIH Funding www.medpagetoday.com/special-repo...

The White House found a loophole around the judge’s orders to lift the freeze that will cripple research and scientific discovery for years.

1 year ago 6 4 0 0

Very important to get this word out!

1 year ago 102 100 5 3
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Trump Cuts Target Next Generation of Scientists and Public Health Leaders A core group of so-called disease detectives, who track outbreaks, was apparently spared. But other young researchers are out of jobs.

Trump Cuts Target Next Generation of Scientists and Public Health Leaders www.nytimes.com/2025/02/18/u...

1 year ago 2 2 0 0
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Trump’s NIH challenges the model that underlies U.S. scientific dominance The 80-year-old partnership between the federal government and research institutions has made the U.S. the leader in scientific innovation. But now a proposed funding cut threatens the arrangement.

www.washingtonpost.com/science/2025...

1 year ago 0 1 0 0
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This campaign needs you now Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

Petition to Reverse the NIH Indirect Cost Cap.

Sign and Circulate.
Mobilize. Organize.

chng.it/LS57Nk7r6k

1 year ago 668 277 11 14
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Genetic buffering mechanisms in SNF2-family translocases SNF2-family DNA translocases, a large family of ATPases, have poorly defined roles in genomic stability. In a recent study, Feng et al. identified a synthetic lethal interaction between the SNF2 trans...

Check out our (@vindignilab.bsky.social) Spotlight article highlighting @durocher1.bsky.social group's discovery of synthetic lethal SMARCAL1-FANCM interaction, revealing a novel genetic buffering mechanism for genome stability at simple repeat regions during replication
www.cell.com/trends/genet...

1 year ago 10 3 1 0

Thank you Petr for hosting me! I had a wonderful time discussing science in Bellinzona!!!

1 year ago 2 0 0 0
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The Vindigni, Krais and @vermalab-washu.bsky.social Labsgiving 2024 featured a full turkey, many laughs and lots of multi-cultural food! 🦃

1 year ago 9 1 0 0

Thank you!

1 year ago 1 0 0 0
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Thank you!

1 year ago 1 0 0 0
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Finally got on the trend and moved to bluer skies! Though our lab photo got the memo long ago 🧬

1 year ago 6 0 0 0

Hi Tatiana can you add me to a starter pack? Thanks!

1 year ago 1 0 1 0

Hi Andrew can you add me to this starter pack? Thanks!

1 year ago 0 0 1 0