Capecitabine in Oncology: Mechanisms, Clinical Applications, Regimens, and Toxicity Management - OncoDaily Capecitabine is an oral chemotherapy for colorectal, breast, and gastric cancer. Learn its uses, dosage, side effects, and DPD safety testing.

Capecitabine in Oncology: Mechanisms, Clinical Applications, Regimens, and Toxicity Management

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This has therapeutic implications! We show that low PRPP levels in NUDT5-KO cells prevent the conversion of nucleobase analogs #5FU #6TG into their toxic nucleosidic forms, leading to chemotherapy resistance.

Could the NUDT5 status of a tumor inform treatment?

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