Hey @MaverickNY .... maybe we’ve been wrong all along.

#AACR18 #ASCO18 #ComicSans twitter.com/roelverhaak/status/99126...

I'm sure that this was probably fun to do, but from my vantage point, it looked incredibly creepy and dystopian. #AACR18 #CyberDetailing #YouWillBeAssimilated

I gotta tell you that flying home today from #AACR18, with all the aviation news, it's hard not to think about this.

Glad I just walked the posters all morning .... #AACR18

.@pkuhn1 you had to leave before our presentation, but I assure you that your Working Group 3 rocked, and @bigjerm823 was the best!

#AACRSSP18 #AACR18

Dr Pardoll: Rick Pazdur of @FDAOncology has been instrumental in accelerating the pace of approval in the immunotherapy space and deserves major kudos for this.

#AACRSSP18 #AACR18

The immune system has a memory, which means there can be a durable response to a course of therapy.

#AACRSSP18 #AACR18

Working across disciplines leads to breakthroughs.

#AACRSSP18 #AACR18

MSI high is kinda like not having a functioning spellcheck while transcribing War and Peace. (This ismenthyoingnwithiur soelkcheck)

#AACRSSP18 #AACR18

Microsattelite instability is a defect in the cells ability to repair DNA damage when cells are dividing & DNA is being copied. This leads to LOTS of mutations that the immune system can recognize, which is why MSI high tumors respond so well to immunotherapy. #AACRSSP18 #AACR18

Tumor specific antigens uniquely mark the cancer cell as different, and T cells can thereby recognize the cell as foreign and try to eliminate it

#AACRSSP18 #AACR18

Talk about explosion 💥 of drug development!

#AACRSSP18 #AACR18

December 2013 immunotherapy was touted as the breakthrough of the year. Five years later is is still the hottest topic, but not mature. When it works, it's amazing, but toxicities can be significant.

#AACRSSP18 #AACR18

Completely blocking CTLA4 or PD1 lead to rapid death in mice. But partial blockade, maybe, could kill the cancer without the killing the patient. Yervoy is an anti- CTLA4 and Opdivo and Keytruda are a anti-PD1.

#AACRSSP18 #AACR18

This is only a small number of the molecules that regulate the T cell immune response, including CTLA4 and PD1, both of which put the brakes on immune response #AACRSSP18 #AACR18

Melanoma is a great case study of the promise of immunotherapy; there are lots of tumor infiltrating lymphocytes that have anticsncer activity in vitro, but in vivo, the cancer throws up defensive walks that need to be broken down first

#AACRSSP18 #AACR18

T cells and antibodies we have in our bodies are like having millions of anticancer weapons. Dr Pardoll.

#AACRSSP18 #AACR18

The immune system: the perfect anti cancer agent (except for those nasty and potentially life threatening side effects) #AACRSSP18 #AACR18

This NYC doc, gave people bacteria (called Coley's toxins) which stimulated an immune response which helped some cancers

#AACRSSP18 #AACR18

First immunotherapy done in early 1900s in NYC, took a looonnnnggg time to get where we are now, but field has exploded in the last few years

#AACRSSP18 #AACR18

Dr drew Pardoll on immunotherapy.

#AACRSSP18 #AACR18

Dr Pazdur of @FDAOncology : who cares about what happens in the artificial environment of a clinical trial? We need to know how the drug will work in the real world.

#AACRSSP18 #AACR18

ThNks to he 21stcentury cures act, patient reported outcomes MUST be reviewed by @FDAOncology #AACRSSP18 #AACR18

And @METUPorg a d @metavivor get a shout out from @FDAOncology @tmprowell, a great friend of advocates #AACRSSP18 #AACR18

.love that we advocates are able to have a dialogue with @FDAOncology deputy commissioner Anna Abrahms, who agrees that stage appropriate advocates should be more involved. #AACRSSP18 #AACR18

😱 ESI eligibility period may change.... they are looking at that 🚨 #NCI #AACR18

A commitment to educate, train and retain the next generation of cancer scientists. A commitment to basic science. This presidential address is inspiring. Let’s hope that the NCI will act on this quickly and efficiently. #AACR18

We need to develop the SoundHound and Waze of cancer. #AACRSSP18 #AACR18

The more we know the more complex cancer becomes. #AACRSSP18 #AACR18

The VA and DoD systems are one where primary and cancer care are delivered together. This the APOLLO program. Will generate tons of data #AACRSSP18 #AACR18