Post-stretch (3 d) response of 👤fetal Airway Smooth Muscle Cell

Mechanical Stretch mimicking continuous pos airway pressure▶️cyclic 5% 0.67 Hz + static 5%/10%
vs control▶️cyclic 5% 0.67 Hz

⏫Proliferation
⏫IL-6
↔️Collagen/Fn deposits
Piezo-indie

#AJPLung 2025
journals.physiology.org/doi/full/10....

Accelerated #EpigeneticAging of #IdiopathicPulmonaryFibrosis🫁

6 #DNAMethylation-based #EpigeneticClocks
Horvath's Clock
Hannum's Clock
AltumAge
PhenoAge
GrimAge
DunedinPAC

IPF🫁(n=10) are "Older" than control🫁(n=6)😎

#AJPLung 2025 @kaminskimed.bsky.social
journals.physiology.org/doi/abs/10.1...