The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting #### Summary points

#ARISEAFRICAtrial is a stepped wedge cluster- this design is useful for interventions delivered at the ICU/hospital level and individual randomisation is difficult. Clusters transition from control to intervention at different times www.bmj.com/content/350/... #ccrdownunder @criticalcarereviews.com

Respiratory support with standard low-flow oxygen therapy, high-flow oxygen therapy or continuous positive airway pressure in adults with acute hypoxaemic respiratory failure in a resource-limited setting: protocol for a randomised, open-label, clinical trial – the Acute Respiratory Intervention StudiEs in Africa (ARISE-AFRICA) study Acute hypoxaemic respiratory failure (AHRF) is associated with high mortality in sub-Saharan Africa. This is at least in part due to critical care-related resource constraints including limited access to invasive mechanical ventilation and/or highly ...

And here is the protocol publication for #ARISEAFRICAtrial: pmc.ncbi.nlm.nih.gov/articles/PMC... #ccrdownunder

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First up on Day 2 of #CCRdownunder is #ARISEAFRICAtrial. Post your questions using the hash tags and follow the live stream here: criticalcarereviews.com
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