Have I burnt your eyes through my aura? Aww poor boy! 😂👠🖕🏻

@findompromo.bsky.social
@promodog.bsky.social

#bosslady #arpi #goddessarpi #ladyrules #bossbabe

I know how to train 🐶s, wanna try out?

@findompromo.bsky.social
@promodog.bsky.social

#bdsm #femdom #indiangoddess #realsession #dominatrix #mistress
#goddessarpi #bosslady #arpi #kolkata

The lioness doesn't chase, she rules! 👢👑

@findompromo.bsky.social
@promodog.bsky.social

#femdom #bdsm #Indiamistress
#humiliation #finsub #slave
#arpi #goddessarpi #bosslady #ladyrules

Poly(ADP-ribose) Polymerase Inhibitor Combinations in First-Line Metastatic Castration-Resistant Prostate Cancer: Increasing Toxicity With Unclear Benefits

Sadly only 17% of pts in #Talapro2 study were treated with subsequent #Parp

That is one among many questions about these parp and #arpi studies raised in this commentary @asco #GU25 #ProstateCancer

ascopubs.org/doi/10.1200/...

Worth revisiting the #BRCAway trial from #GU24 in the context of #GU25 and #Talapro2

With regard to evaluation of sequencing #Parp and #ARPI the numbers of pts are very small (8 with cross over) and the CIs are very wide.
#ProstateCancer

A related question on #Talapro2 that remains unanswered is sequencing of #ARPI & #parp aside from a very small phase 2 trial with far too few pts

Sequencing #Parp would defer toxicity for mos-yrs

& worth noting that low% of mCRPC pts getting 2nd line tx predates #parp era
#GU25