Alterations of Plasma Metabolites Associated with Sickle... : Clinical Journal of the American Society of Nephrology sociation have not been fully characterized. We utilized metabolomic profiling to gain insight into the pathobiology of SCT. Methods: We used a nontargeted metabolomics approach (Metabolon Global Discovery Panel) to measure baseline plasma levels of 851 metabolites in 986 older Black or African American women with SCT (mean age 61 ± 7 years) compared to 998 age- and race-matched controls without SCT from the prospective Women’s Health Initiative (WHI) study. Age-adjusted linear regression was used to assess the association between metabolite levels and SCT. Replication was performed in an independent sample of 1,070 African American men and women (including 70 with SCT) from the Atherosclerosis Risk in Communities (ARIC) study. Results: In age-adjusted models, 69 metabolites were significantly associated with SCT in WHI after correction for multiple testing. Many of the SCT-associated metabolites are markers of kidney glomerular filtration (eGFR) and/or related to oxidative stress metabolic pathways known to be altered in SCD homozygotes. Of the 64 SCT-associated metabolites available for replication, 25 or 39% were replicated in the ARIC study. Inclusion of SCT-associated metabolites was associated with significantly better risk prediction of incident ESKD in WHI among SCT individuals compared with a baseline model adjusted for age + estimated glomerular filtration rate (eGFR). Conclusions: We identified and replicated metabolites associated with SCT, many of which are related to eGFR and/or pathways altered in SCD (e.g., oxidative stress, membrane remodeling). These results suggest that plasma metabolomic profiling may be useful in ESKD risk stratification for individuals with SCT, meriting validation in larger cohorts. Copyright © 2026 by the American Society of Nephrology...

New study in #ASNCJASN shows that metabolomic profiling may help identify those at higher risk for kidney disease, underscoring the importance of further research in larger populations.

Kidney casts contain high levels of PROM1, a marker linked to cell damage and dedifferentiation based upon new #ASNCJASN study. kidney.pub/CJASN0982

What do the findings of a new #ASNCJASN study suggest about the role of FGF23 in Dent disease type 1? kidney.pub/CJASN0978 David S. Goldfarb MD

Obesity in kidney donors raises risks, but BMI alone isn’t enough. Better tools (like fat distribution imaging) and personalized care can improve fair, safe donor selection—though some risks remain. #ASNCJASN kidney.pub/CJASN1030

Could rapidly increasing plasma fibroblast growth factor 23 (FGF23) levels directly cause faster progression to kidney failure in children with CKD, or are they primarily a biomarker of other underlying, actively damaging mechanisms? #ASNCJASN kidney.pub/CJASN0954

New #ASNCJASN Podcast: Dr. Saland summarizes the main findings from his study on "Final Results of the ILLUMINATE-A Phase 3 Clinical Trial of Lumasiran for Primary Hyperoxaluria 1" Listen here: kidney.pub/CPOD0916

This #ASNCJASN study provides a rationale for using a hierarchical composite endpoint (HCE) instead of traditional kidney outcomes in FSGS studies kidney.pub/CJASN0994

Can comprehensive genetic testing effectively identify the underlying genetic causes of pediatric kidney cysts and improve diagnostic accuracy and clinical management, particularly in children with or without a known family history of kidney disease? Read #ASNCJASN kidney.pub/CJASN1027

This post hoc FIDELITY analysis published in #ASNCJASN examined the efficacy and safety of finerenone in patients with chronic kidney disease, T2D, and a history of nephrectomy. Read the full article here: kidney.pub/CJASN0932

This #ASNCJASN systematic review and meta-synthesis of 15 studies from Canada, Australia, and New Zealand highlights challenges faced by Indigenous patients and suggests that engaging Indigenous communities is crucial for developing strategies to improve access. Read more: kidney.pub/CJASN1005

Frailty is a common issue in kidney disease, affecting patients' health outcomes. This #ASNCJASN study reviewed 136 articles to evaluate different frailty measurement tools. Read the scoping review: kidney.pub/CJASN0998

New Podcast: Dr. McCausland summarizes the main findings from his study on "Effect of finerenone on eGFR slope across different levels of baseline albuminuria and eGFR: Insights from FINEARTS-HF" #ASNCJASN kidney.pub/CPOD0849

Males with chronic kidney disease (CKD) experience worse outcomes than females. This #ASNCJASN research explored whether sex-based differences in biomarkers could account for this difference in risk. Read more: kidney.pub/CJASN0979 @donmaston09.bsky.social

This #ASNCJASN study explored the link between chronic kidney disease (CKD) and employment status, finding that individuals with CKD are more likely to leave the workforce compared to those with normal kidney function. Check it out: kidney.pub/CJASN1003

This #ASNCJASN research reports results of a national survey of nephrology fellows to assess their attitudes towards, and perceptions of, health equity in fellow training and kidney care. Read more: kidney.pub/CJASN0991

This #ASNCJASN Kidney Health Watch examined the relationship between annual heat exposure and risk of kidney disease, focusing on how this association varies across different socioeconomic and geographic regions in the United States. Read the article here: kidney.pub/CJASN0935

New Podcast: Dr. Parikh, Dr. Malhotra, and Dr. Thiessen Philbrook summarize the main findings from their study on "Dynamic Risk Prediction of Graft Failure After Deceased Donor Kidney Transplant". Tune in: kidney.pub/CPOD0883 #ASNCJASN

From a broad range of findings appearing in #ASNCJASN in 2025, the Editor-in-Chief has selected the following articles to highlight as Editors’ Choice Articles.

Find the articles in today’s ASN In The Loop, and online at: kidney.pub/CJASNReco...

The February issue of CJASN is now available online! Topics covered include: - Impact of SGLT2 Inhibitors on Hyperfiltration and Albuminuria - Long-Term Outcomes in Severe ANCA Vasculitis- and more. Check out the issue here: kidney.pub/CJASN-0226 #ASNCJASN Cover by: Luis Rafael Álvarez Velázquez.

This trial in #ASNCJASN explored the association between complete remission of proteinuria and kidney function decline during sparsentan or irbesartan treatment. Read more: kidney.pub/CJASN0961

This #ASNCJASN study looked at kidney transplant outcomes in children with ANCA-associated vasculitis. Researchers found that 97% of patients were alive and 86% had functioning grafts after a median follow-up of 53 months. Read more: kidney.pub/CJASN0936 Chia Wei Teoh 張嘉偉

This #ASNCJASN study explored how kidney volume affects acute kidney injury (AKI) risk after cardiovascular surgery. Read more: kidney.pub/CJASN0911

This #ASNCJASN article reviews existing biomarkers to evaluate complement activity, discusses emerging ones, and highlights the difficulties in bringing research-based markers into clinical use. Read more: kidney.pub/CJASN0967

In a #ASNCJASN Kidney Cross-Talk, authors explore recent evidence on Lipoprotein(a) and chronic kidney disease (CKD). Read more: kidney.pub/CJASN0968 Bob Roshanravan

When is Genetic Testing Needed in Glomerular Disease? Check out this perspective in #ASNCJASN kidney.pub/CJASN0964

The January issue of CJASN is now available online! Topics covered this month include: - Competing Risk of Dialysis or Death in Diabetes - Hypertension Management in Patients Receiving Hemodialysis - and more Check out the issue here: kidney.pub/CJASN-0126 #ASNCJASN Cover by Wang et al.

Check out this new #ASNCJASN Patient Voice article accompanying “Qualitative Perspectives from African American Adults with CKD on Community-Based Fruit and Vegetable Promotion” by Dodgen et al. in the December issue: kidney.pub/CJASN0929 @immskidney.bsky.social @glendaroberts.bsky.social

The INFINITI trial assessed the physiological effects of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in kidney transplant recipients (KTR). Read more in this recent #ASNCJASN article: kidney.pub/CJASN0951

In this #ASNCJASN article, researchers found that patients from highly disadvantaged neighborhoods waited longer and were less likely to be placed on the kidney transplant waitlist. Read more: kidney.pub/CJASN0939

Patient uncertainty regarding the cause of their kidney disease highlights a persistent gap in kidney care. This #ASNCJASN study is conducting a structured interview study in dialysis facilities throughout Central California, a region with among the highest incidence of ESKD: kidney.pub/CJASN0965