Integrated LC-MS/MS Metabolomics
1️⃣Angiotensin II-treated Smooth Muscle Cells
2️⃣Apoe-/-🐭Aorta +Angiotensin II

Common metabolites
⏫5-HETE
⏫L-carnitine
⏫lysophosphatidylcholine (0:0/20:4)
⏬salicylamide

#Biomed_MDPI 2026
www.mdpi.com/2227-9059/14...

Vascular Smooth Muscle Cell Metabolic Disorders & Aortic Aneurysm/Dissection

OXPHOS
ACO2 NR1D1 OGDH Pyruvate carboxylase

Glycolysis
PKM2, lactylation, ubiquitination

Hexosamine
PSMC1 O-GlcNAcylation ⬇️Proteasome

Sphingolipid
KLF9, GM3, ferroptosis

#Biomed_MDPI 2025
www.mdpi.com/2227-9059/13...

#IntussusceptiveAngiogenesis #IntussusceptiveLymphangiogenesis in blood/lymphatic #VascularTumors

A beautiful histologic gallery of transluminal pillars (<4 μm φ)/meshes (≥4 μm φ)

Lucio Díaz-Flores & Miriam González-Gómez labs #Biomed_MDPI 2024
www.mdpi.com/2227-9059/12...