Top left to right: The culture in a Petri dish shows light-coloured colonies of Streptomyces rimosus ATCC 10970 growing on a yellowish medium. A blue arrow points from the Petri dish to the linear genomic map. This horizontal line represents a biosynthetic gene cluster. The vertical colour bars indicate specific genes, numbered 1, 3, 6, 9, 14, 21, 23, and then further right, numbers 29, 30, 31, 35, 44 and 45, which code for the enzymes needed to build complex molecules. Bottom of the picture shows two chemical products. Thin blue lines lead from specific sections of the gene cluster to the chemical structures of two secondary metabolites: oxytetracycline (OTC), a broad-spectrum antibiotic, shown on the left side. The structure shows its characteristic four-ring core. On the right is a much larger, more complex structure of rimocin (RIM), an antifungal compound.
Modulating Complex Secondary Metabolism in Streptomyces rimosus🧫 by Targeted Genome Engineering 🧬🔬
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