Lesion evidence indicates distinct roles:
🧠 Orbitofrontal cortex (OFC) damage abolishes sensitivity to expectancy.
🧠 Lateral prefrontal cortex (LPFC) damage shows only modest, non-significant effects compared to controls.
(Shown using #CNV #ERP that tracks anticipation)

#BrainLesion #Prediction

Predictive encoding of auditory sequences in the human prefrontal cortex Humans extract regularities from the environment to form expectations that guide perception and optimize behavior. Although the prefrontal cortex (PFC) is central to this process, the relative contrib...

🤔How does the human brain predict unexpected sounds?
Our new study shows that the prefrontal cortex doesn’t work as a single unit. Instead, the orbitofrontal and lateral prefrontal cortex make distinct, time-sensitive contributions. #iEEG #BrainLesion #OFC #LPFC
doi.org/10.1101/2025...