"Transferrin Receptor-1: Expression in Canine Mammary Tumours and In Vitro Therapeutic Applications". The publication was realized by colleagues at #BtBsUNIMIB together with other authors. #BtBsPub DOI: 10.1111/vco.70000 pmc.ncbi.nlm.nih.gov/articles/PMC...

TRP channels and cancer modulation: a voyage beyond metabolic reprogramming, oxidative stress and the advent of nanotechnologies in targeted therapy - Journal of Experimental & Clinical Cancer Researc... Transient receptor potential (TRP) channels are a large family of non-selective cation channels that play critical roles in cellular homeostasis and signal transduction. Recent investigations have cle...

"TRP channels and cancer modulation: a voyage beyond metabolic reprogramming, oxidative stress and the advent of nanotechnologies in targeted therapy". The publication was realized by colleagues at #BtBsUNIMIB together with other authors. #BtBsPub jeccr.biomedcentral.com/articles/10....

Dye-loaded hybrid core-shell gold nanoparticles for sensitized singlet oxygen production in radiotherapy Photodynamic therapy (PDT) is an efficient, clinically approved, light-activated cancer treatment. However, it is mostly effective for superficial tre…

"Dye-loaded hybrid core-shell gold nanoparticles for sensitized singlet oxygen production in radiotherapy". Researchers from the Università degli Studi di Milano-Bicocca authored the publication, #unimib, #BtBsUNIMIB, #BtBsPub. www.sciencedirect.com/science/arti...

"Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach". The publication was co-authored by colleagues at #BtBsUNIMIB and other contributors. #BtBsPub doi: 10.3389/fncel.2025.1616911 www.frontiersin.org/journals/cel...

Redox homeostasis in ferroptosis and aging: a causal role for fard-1 and dhs-25 in Caenorhabditis elegans Aging is a natural process characterized by a progressive physiological decline that undermines health and well-being in the elderly population. Oxida…

We are proud to announce this article: "Redox homeostasis in ferroptosis and aging: a causal role for fard-1 and dhs-25 in Caenorhabditis elegans". The publication was realized by colleagues at #BtBsUNIMIB together with other authors. #BtBsPub www.sciencedirect.com/science/arti...

Hypokalemia and bradycardia unmask the loss-of-function phenotype of a Brugada Syndrome SCN5A mutation AbstractBackground and Aims. Loss-of-function (LOF) mutations of the cardiac Na+ channel (SCN5A) are causatively associated with the Brugada Syndrome (BrS)

"Hypokalemia and bradycardia unmask the loss-of-function phenotype of a Brugada Syndrome SCN5A mutation". The publication was realized by colleagues at #BtBsUNIMIB together with other authors. #BtBsPub academic.oup.com/europace/art...

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We're excited to share this publication: "Dendritic cells in focus: mapping functional diversity through technological innovation". The publication was co-authored by colleagues at #BtBsUNIMIB and other contributor. #BtBsUNIMIB, #BtBsPub febs.onlinelibrary.wiley.com/doi/10.1002/...

Checkout this article we found at PLOS: "A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in ...". The publication was realized by colleagues at #BtBsUNIMIB together with other authors. #BtBsPub dx.plos.org/10.1371/jour...

Small-molecule SERCA2a Stimulators: Novel Ino-lusitropic Agents | ECR Journal. The publication was realized by colleagues from the #BtBsUNIMIB, #BtBsPub. www.ecrjournal.com/articles/dev...

Urban Phytoremediation: A Nature-Based Solution for Environmental Reclamation and Sustainability. The publication was co-authored by colleagues at #BtBsUNIMIB and other contributors. #BtBsPub www.mdpi.com/3390210 #mdpiplants via @Plants_MDPI

NF-κB-mediated cytokine secretion and glutamate metabolic reprogramming converge in breast cancer brain tropism. The publication was co-authored by colleagues at #BtBsUNIMIB and other contributors. #BtBsPub www.sciencedirect.com/science/arti...

SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus Summary: The transcriptional regulators SOX2 and NR2F1 drive the development of the visual thalamus. Mutations in these genes cause visual impairment in humans.

SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus. The publication was realized by colleagues at #BtBsUNIMIB together with other authors. #BtBsPub journals.biologists.com/bio/article/...

Xanthohumol destabilizes the structure of amyloid-β (Aβ) oligomers and promotes the formation of high-molecular-weight amorphous aggregates This study provides a comprehensive structural analysis of prenylflavonoids (PFs) interaction with Aβ1–42 oligomers, revealing their potential to modu…

Xanthohumol destabilizes the structure of amyloid-β (Aβ) oligomers and promotes the formation of high-molecular-weight amorphous aggregates.The publication was co-authored by colleagues at #BtBsUNIMIB and other contributors. #BtBsPub www.sciencedirect.com/science/arti...

Frontiers | Highly differentiated T cells link systemic and vascular inflammation in a mouse model of recurrent psoriasis Psoriasis is a chronic inflammatory skin-disease associated with cardiovascular comorbidities. In patients, T cells with a skin-primed phenotype are expanded...

Highly differentiated T cells link systemic and vascular inflammation in a mouse model of recurrent psoriasis. The publication was realized by colleagues at #BtBsUNIMIB together with other authors. #BtBsPub www.frontiersin.org/journals/imm...

Genomically integrated cassettes swapping: bringing modularity to the strain level in Saccharomyces cerevisiae A novel synthetic biology strategy that allows standardized swapping or removal of expression cassettes already integrated into the yeast genome.

#BtBsPub: Genomically integrated cassettes swapping: bringing modularity to the strain level in Saccharomyces cerevisiae. The publication was led by colleagues from the #BtBsUNIMIB. academic.oup.com/femsyr/artic...

Solvent-Driven Modulation of Shuttling Dynamics in an Autonomous Chemically Fueled Information Ratchet The performance of artificial molecular machines relies on the interplay between molecular design and environmental factors, yet how solvation shapes their energy landscapes and kinetics remains poorl...

Solvent-Driven Modulation of Shuttling Dynamics in an Autonomous Chemically Fueled Information Ratchet | The Journal of Physical Chemistry B. A #BtBs and co-authors publication. #BtBsPub #BtBsUNIMIB #unimib pubs.acs.org/doi/10.1021/...

Dual-Targeting Strategy to Repurpose Cetuximab with HFn Nanoconjugates for Immunotherapy of Triple-Negative Breast Cancer Triple-negative breast cancer (TNBC) is a highly aggressive and treatment-resistant malignancy characterized by the lack of targeted therapies and poor clinical outcomes. Here, we present a dual-targeting strategy combining the anti-EGFR monoclonal antibody cetuximab (CTX) with H-ferritin (HFn), a nanoparticle targeting transferrin receptor 1 (TfR1), for potential immunotherapy in CTX-resistant tumors. The HFn–CTX nanoconjugate exhibited favorable biophysical properties and good tumor accumulation and significantly enhanced antibody-dependent cellular cytotoxicity (ADCC) in TNBC spheroids compared to CTX alone. Conversely, glioblastoma spheroids did not exhibit comparable reactivity. This effect correlated with elevated cell-surface EGFR expression and plasma-membrane lingering of the nanoconjugate in TNBC cells, facilitating robust immune activation. Biodistribution studies showed selective accumulation of the HFn–CTX nanoconjugate in TNBC tumors in vivo. These findings highlight the potential of HFn–CTX nanoconjugates to repurpose CTX for refractory cancers that express EGFR at high levels, such as TNBC, leveraging dual-receptor targeting to amplify immune-mediated cytotoxicity and overcome resistance.

Dual-Targeting Strategy to Repurpose Cetuximab with HFn Nanoconjugates for Immunotherapy of Triple-Negative Breast Cancer | ACS Applied Materials & Interfaces #BtBsUNIMIB #BtBsPub #UNIMIB pubs.acs.org/doi/10.1021/...

#BtBsPUB "Exploring the anti-inflammatory effects of curcumin encapsulated within ferritin nanocages: a comprehensive in vivo and in vitro study in Alzheimer’s disease" by #ProsperiLab_BtBs #BarbieriLab_BtBs and co-authors. #BtBsUNIMIB UNIMIB pubmed.ncbi.nlm.nih.gov/39551771/

#BtBsPUB "Estrogen-related differences in antitumor immunity and gut microbiome contribute to sexual dimorphism of colorectal cancer" by #StratiLab_BtBs #FacciottiLab_BtBs #BaeriLab_BtBs & co-authors. #BtBsUNIMIB @unimib pubmed.ncbi.nlm.nih.gov/39548749/

Animal pollination shapes fruits market features, seeds functional traits and modulates their chemistry - Scientific Reports Scientific Reports - Animal pollination shapes fruits market features, seeds functional traits and modulates their chemistry

Beautiful paper #BtBsPUB "Animal pollination shapes fruits market features, seeds functional traits and modulates their chemistry" by #LabraLab_BtBs #GalimbertiLab_BtBs #GuzzettiLab_BtBs & co-authors #BtBsUNIMIB #UNIMIB www.nature.com/articles/s41...

Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification

#BtBsPUB by Luca Sala and co-authors "Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification" in CIRCULATION journal. #SalaLab_BtBs #BtBsUNIMIB #unimib www.ahajournals.org/doi/10.1161/...