Latest #CDlab paper on BioRxiv: www.biorxiv.org/content/10.6...
PhD student Bert van Herck developed a route towards efficiently delivering lipids and proteins to synthetic cells through DNA-driven fusion of SUVs to GUVs.
Great collaboration with labs of Gijsje Koendrink & Stefan Vogel.
Latest #CDlab paper on nanopore protein sequencing now published in JACS: pubs.acs.org/doi/full/10....
Here, Justas Ritmejeris, Xiuqi Chen, collaborator Bauke Albada, and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!
Latest #CDlab paper out in Molecular Cell!
see this thread by @RomanBarth2
Latest #CDlab paper on nanopore protein sequencing on @biorxivpreprint.bsky.social: www.biorxiv.org/cgi/content/...
Here, Justas Ritmejeris, @xiuqichen.bsky.social, collaborator @albadalab.bsky.social and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!
our #CDlab has openings as well: ceesdekkerlab.nl/come-join-us/
Thanks Mahipal!
You share this honor as well, since you and so many other #CDlab team members contributed so much to all our scientific discoveries.
#CDlab outing 2025: sailing the Dutch waters with our lab members!
(drone credit @xiuqichen.bsky.social)
WORK: 5 (!) openings in our #CDlab, check it out: ceesdekkerlab.nl/come-join-us/
Congrats to our #CDlab postdoc @xiuqichen.bsky.social for winning an NWO VENI grant for his research on histone epigenetics with nanopore sequencing!
Congrats to all other winners as well www.nwo.nl/en/researchp... inclusing ex-CDlab member @thedneva.bsky.social, now PI at Utrecht
Here's a new very exciting paper from our #CDlab: www.cell.com/cell-reports...
In an exemplary in vitro/in vivo study, 1st authors @btanalikwu.bsky.social & Alice Deshayes showed that dense linear protein arrays (e.g. telomeres) do stop loop-extruding SMCs!
Great collaboration with Marcand lab.
Latest #CDlab paper online now:
Cohesin supercoils DNA during loop extrusion
www.cell.com/cell-reports...
This extensive study was led by Jan Michael Peters at Vienna; our lab contributed mostly modeling of plasmid supercoiling (@romanbarth.bsky.social) and single-molecule data (Richard Janissen).
Onze #CDlab mensen komen op heel verschillende plekken terecht.
Trots op voormalig promovenda Stephanie Heerema die bij ons promoveerde in de bionanotechnologie en nu bij offshorebedrijf Allseas majeure veranderingen doorvoert met de inzet om op termijn CO2-neutraal te zijn.
nos.nl/artikel/2570...
Latest #CDlab paper out now in Nucleus: www.tandfonline.com/doi/epdf/10....
This short article sketches the state of the art of the field that studies the structure and dynamic gating mechanism of the nuclear pore complex
Latest #CDlab paper on @biorxivpreprint.bsky.social:
Lipid flip flop regulates the shape of growing and dividing synthetic cells
www.biorxiv.org/content/10.1...
Here, postdoc Rafa Lira studied GUV growth by SUV fusions to show that lipid flip flop is key for low curvature stress and symmetric buds
Out now! @biorxivpreprint.bsky.social from my PhD at #CDlab
We design, experimentally test, and simulate a library of designer FG-nucleoporins.
We identify key biophysical properties of their amino acid sequence that tune their selective barrier function.
Congrats to all co-authors! 🥳
Latest #CDlab paper on @biorxivpreprint.bsky.social: Spatial control of karyopherin binding avidity in NPC mimics revealed by designer FG-Nucleoporins
www.biorxiv.org/content/10.1...
With experiments & MD simulations we study de novo designed proteins for selective transport through nuclear pores
We have 3 openings for ambitious postdocs or PhD students in our #CDlab - for exciting single-molecule biophysics research on nuclear pores, peroxisomes, or archaeal divisomes.
Check it out and apply: ceesdekkerlab.nl/come-join-us/
RT=nice!
Huge congrats to our #CDlab PhD student @romanbarth.bsky.social for winning the prestigious 2025 Weintraub Award for his PhD thesis work on SMC motor proteins!
www.fredhutch.org/en/news/rele...
Great honor and well deserved Roman!
Latest #CDlab paper online in @labonachip.rsc.org: pubs.rsc.org/en/content/a...
Here, 1st authors Alex Joesaar & Martin Holub developed a microfluidics platform to extract and study full length megabase-size genomes in microfluidic chambers (where they are protected against shearing by flow)!
Latest #CDlab paper now at @biorxivpreprint.bsky.social: www.biorxiv.org/content/10.1...
In this paper, we identify two amino acid motifs on CTCF that impede cohesin-mediated DNA loop extrusion - important as CTCF and cohesin are crucial to the structure and regulation of our chromosomes.
Congrats to #CDlab graduate Miloš Tišma for winning a Rubicon grant to pursue postdoc research on antibiotic resistance at Harvard Medical School!
Latest #CDlab paper by Nicola De Franceschi ea now in eLife @elife.bsky.social:
'Interaction hierarchy among Cdv proteins drives recruitment to membrane necks', an in vitro study of the fascinating and unique proteins machinery that drives cell division in archaea elifesciences.org/reviewed-pre...
New discovery from our #CDlab reported in Cell @cp-cell.bsky.social today:
SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion!
www.sciencedirect.com/science/arti...
1/
Haha, prompted by the new-born son of #CDlab postdoc Rafa De Lira, graduate student @btanalikwu.bsky.social has come up with a proposal for a set of new research experiments...
Our paper of today is the result of the creative hard work of first authors Richard Janissen and @romanbarth.bsky.social in our #CDlab, in collaboration with Iain Davidson and Jan-Michael Peters of the IMP Vienna BioCenter.
Enjoy reading our paper here: www.science.org/doi/10.1126/...
10/10
Nice story in @nature.bsky.social of how 4 science students developed their friendship over the years: www.nature.com/articles/d41...
Great to see former #CDlab graduate student @tismaa.bsky.social featured here!
Latest #CDlab paper in Nucleic Acid Research:
academic.oup.com/nar/article/...
Great work by Alejandro Martin-Gonzalez,
@tismaa.bsky.social ea collaboring with @gruberlab.bsky.social, showing the interplay of DNA supercoiling & ParB condensation, 2 processes that set bacterial genome organization.
Latest #CDlab paper: Synchronization of E. coli Bacteria Moving in Coupled Microwells: onlinelibrary.wiley.com/doi/epdf/10....
E. coli bacteria swim in sync in weakly coupled neighboring microcavities!
Great work led by @AleksandreJapa from from Farbod Alijani's lab, to which I also contributed
