knowledge gaps in HT
huge knowledge gaps in pediatric hypertension
from pubmed.ncbi.nlm.nih.gov/35570999/ in @kireports.bsky.social
@rahulchanchlani.bsky.social at @hypertensioncanada.bsky.social #CHC25
HT is undiagnosed in kids
Rahul @rahulchanchlani.bsky.social starts off with a bang
Hypertension in Children
Congrats for the young Investigator too!
@hypertensioncanada.bsky.social #CHC25
summary slide
And his conclusions!
Excellent overview of really old to the rapidly emerging field of hypertension drugs
@drjmluther.bsky.social at @hypertensioncanada.bsky.social #CHC25
zilebesiran summary
How about the siRNA (hot off the press from yesterday's @jama.com )
Zilebesiran summary evidence
@drjmluther.bsky.social at @hypertensioncanada.bsky.social #CHC25
ASI evidence
The summary of the data on ASIs so far
@drjmluther.bsky.social at @hypertensioncanada.bsky.social #CHC25
pharmacology of ASis
The details of the existing ASIs in development
Note the selectivity of Bax/Lorun/Vica -drostats
But also the half life, Bax > Lorun > Vica
@drjmluther.bsky.social at @hypertensioncanada.bsky.social #CHC25
possible role of ASis
After covering Aprocitentan (see www.nephjc.com/news/aprocit...)
@drjmluther.bsky.social moves on to Aldo synthase inhibitors
This is his take on the potential role of ASIs
#NephJC chat on Lorundrostat: www.nephjc.com/news/advance...
#CHC25 @hypertensioncanada.bsky.social
This is a fantastic table of all BP drug classes approval over time
We have come a long way
@drjmluther.bsky.social at @hypertensioncanada.bsky.social #CHC25
risk of aortic dissection with DBP
diastolic hypertension and risk of aortic dissection - note the relative risk scales!
@drjmluther.bsky.social at @hypertensioncanada.bsky.social #CHC25
old drugs in HT
Plenary at @hypertensioncanada.bsky.social with @drjmluther.bsky.social on new drugs
He starts of with the really old drugs!
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