CYP3A5 unexpectedly regulates glucose metabolism

In this study, scientists reveal that #CYP3A5 enriches the glucose transporter #GLUT1 at the plasma membrane by restricting the translation of TXNIP, thereby playing a beneficial role in the growth of #PancreaticDuctalAdenocarcinoma (PDAC) cells. #medsky

#OpenAccess: www.sciencedirect.co...

It's interesting that cannabis users were included since terpenes present in cannabis might be inducers of CYP3A5* ( #CYP3A5 is induced by phenobarbital**). It did not seem to affect the study results.
* doi.org/10.1016/0006...
** doi.org/10.1006/abbi...
referenced by
www.jbc.org/article/S002...