Genetic architecture of #CalcificAorticValveStenosis

GWAS meta-analysis 14,819 cases/941,863
RNAseq eQTL TWAS ~500
MR
Prioritization of causal genes for #AorticValve drug targets

PRRX1
NAV1
ALDH1A2
MUC4
ACTR2
SMAD9
PALMD
ATP13A3
FADS2
TWIST1
#NatureComms 2024
www.nature.com/articles/s41...