🌟Our new cover for #CellReportsMedicine features a study by Eloy Santos Pujol et al. diving deep into the biology of one of the world’s oldest living #supercentenarians!

🔗 DOI: 10.1016/j.xcrm.2025.102368

Book a virtual meeting with one of our editors to discuss your research and if it would be a good fit at #CellReportsMedicine: http://dlvr.it/TNYHqT

Meet with a Cell Reports Medicine editor to discuss your research

Book a virtual meeting with one of our editors to discuss your research and if it would be a good fit at #CellReportsMedicine: http://dlvr.it/TN2Z8Q

Meet with a Cell Reports Medicine editor to discuss your research

Book a virtual meeting with one of our editors to discuss your research and if it would be a good fit at #CellReportsMedicine: http://dlvr.it/TN2Z5m

Weight-loss maintenance is accompanied by interconnected alterations in circulating FGF21-adiponectin-leptin and bioactive sphingolipids Fiorenza et al. reveal selective and dynamic alterations in energy-balance-regulating metabokines and sphingolipids throughout weight loss, weight-loss maintenance, and weight regain in adults with obesity. Weight-loss maintenance elicits distinct remodeling patterns within the FGF21-adiponectin-leptin-sphingolipid axis as compared with weight regain, and these changes are associated with cardiometabolic health outcomes.

Kicking off 2025 with a highlight from our 2024 study in #CellReportsMedicine @cellpress.bsky.social

We uncovered the potential role of a metabokine-sphingolipid axis in sustaining weight loss in humans with #obesity.

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