Access to chiral α-methyl-α-aryl carboxylic acids via phosphoric acid-catalyzed kinetic resolution of biaryl oxazepines We disclose herein a chiral phosphoric acid-catalyzed kinetic resolution of racemic biaryl oxazepines with alcohols, giving a series of biaryl oxazepines and imidate products bearing a chiral center i...

🔥 In this work, #ChiralPhosphoric #acid-catalyzed kinetic resolution of racemic biaryl oxazepines with alcohols affords enantioenriched biaryl oxazepines and imidates. #Hydrolysis gives α-methyl-α-aryl carboxylic acids with high yield and enantioselectivity.

🔗 doi.org/10.1039/D5QO00953G