Comprehensive metabolic profiling across five lifespan stages in murine hippocampus and cortex reveals sex-related variation in age-related cognitive decline - Communications Biology Integrated behavioural & metabolomic profiling across the mouse lifespan reveals sex-specific brain metabolic reprogramming underlying divergent trajectories of age-related cognitive decline.

Comprehensive metabolic profiling across five lifespan stages in murine hippocampus and cortex reveals sex-related variation in age-related cognitive decline #CommunBiol #MassSpec www.nature.com/articles/s42...

Towards a universal cross-linking mass spectrometry approach for protein structure analysis with homo-bi-functional photo-activatable cross-linkers - Communications Biology The authors report the use of homo-bi-functional photo-activatable cross-linkers for protein structural studies by cross-linking mass spectrometry. They theoretically cross-link any-to-any amino acid ...

Towards a universal cross-linking mass spectrometry approach for protein structure analysis with homo-bi-functional photo-activatable cross-linkers #CommunBiol www.nature.com/articles/s42...

Zebrafishology, study design guidelines for rigorous & reproducible data using zebrafish

Actually, this is an entertaining reading piece for a non-fishman like me😀

Reminder: Zebrafish is an emerging model of #Aortopathy!

Victoria Bedell lab #CommunBiol 2025
www.nature.com/articles/s42...

Octadecanoids as emerging lipid mediators in cnidarian-dinoflagellate symbiosis - Communications Biology Oxylipin profiling in the sea anemone Exaiptasia diaphana with different symbionts identifies stereospecific lipid signals. Results suggest that oxylipin regulatory pathways shape cnidarian–dinoflagel...

Octadecanoids as emerging lipid mediators in cnidarian-dinoflagellate symbiosis #CommunBiol #MassSpec www.nature.com/articles/s42...

Decoding adult murine pancreatic islet cell diversity through cell type-resolved proteomics and phosphoproteomics - Communications Biology Here, the authors employ cell sorting and sensitive mass spectrometry to generate a comprehensive proteomic and phosphoproteomic resource, revealing inflammation responses and cell-specific signaling,...

Decoding adult murine pancreatic islet cell diversity through cell type-resolved proteomics and phosphoproteomics #CommunBiol #MassSpec www.nature.com/articles/s42...

Metabolomic landscape of fetal organ development during late gestation in mice - Communications Biology A comprehensive metabolomic atlas of major fetal organs in late-gestation mice by integrates untargeted and targeted metabolomics with multi-omics data, offering new insights into fetal development and metabolic preparation for birth.

Metabolomic landscape of fetal organ development during late gestation in mice #CommunBiol #MassSpec www.nature.com/articles/s42...

Multiplexed phosphoproteomics of low cell numbers using SPARCE - Communications Biology Streamlined Phosphoproteomic Analysis of Rare CElls (SPARCE) enables robust quantification of proteomes and phosphoproteomes from just 1,000 FACS-sorted cells, advancing signalling analysis in rare po...

Multiplexed phosphoproteomics of low cell numbers using SPARCE #CommunBiol #MassSpec www.nature.com/articles/s42...

The molecular signature of heat stress in sweat reveals non-invasive biomarker candidates for health monitoring - Communications Biology The molecular signature of heat stress in sweat reveals promising biomarker candidates for heat stress monitoring and detection. Once validated, these biomarkers can be clinically implemented through ...

The molecular signature of heat stress in sweat reveals non-invasive biomarker candidates for health monitoring #CommunBiol #MassSpec www.nature.com/articles/s42...

Real time characterization of the MAPK pathway using native mass spectrometry - Communications Biology Native mass spectrometry enables real time characterization of MAPK phosphorylation cascade and impact of oncogenic RAS mutants on kinetics.

Real time characterization of the MAPK pathway using native mass spectrometry #CommunBiol www.nature.com/articles/s42...

The proteomic landscape of stool-derived extracellular vesicles in patients with pre-cancerous lesions and colorectal cancer - Communications Biology This work uncovers the complex proteomic landscape of stool-derived extracellular vesicles (EVs). These findings serve as the framework for future stool EV biomarker discovery in gastrointestinal trac...

The proteomic landscape of stool-derived extracellular vesicles in patients with pre-cancerous lesions and colorectal cancer #CommunBiol #MassSpec www.nature.com/articles/s42...

Proteomic and metabolomic analyses of the human adult myocardium reveal ventricle-specific regulation in end-stage cardiomyopathies - Communications Biology Human myocardial proteomic and metabolomic analyses reveal ventricle-specific metabolic remodelling from normal hearts to heart failure, showing differential regulation in glucose and lipid metabolism...

Proteomic and metabolomic analyses of the human adult myocardium reveal ventricle-specific regulation in end-stage cardiomyopathies #CommunBiol #MassSpec www.nature.com/articles/s42...